A5022746657- Neonatal and fetal brain pathology
- Acute Myeloid Leukemia Research
- Fetal and Pediatric Neurological Disorders
- Bone and Joint Diseases
- Advanced MRI Techniques and Applications
- Bone health and treatments
- Atomic and Subatomic Physics Research
- Streptococcal Infections and Treatments
- Connective tissue disorders research
- Wnt/β-catenin signaling in development and cancer
- Sarcoma Diagnosis and Treatment
- Cancer-related gene regulation
- Infectious Encephalopathies and Encephalitis
- Radiomics and Machine Learning in Medical Imaging
- Infectious Diseases and Tuberculosis
- Soft tissue tumor case studies
- Acute Lymphoblastic Leukemia research
- Historical, Religious, and Philosophical Studies
- Classical Philosophy and Thought
- Classical Antiquity Studies
- Neonatal Respiratory Health Research
- Orthopedic Infections and Treatments
Centre Hospitalier Universitaire de Rennes
2015-2023
Hôpital Pontchaillou
2015-2019
Hôpital Universitaire Dupuytren
2013
The primary objective of this study was to evaluate changes in cerebral blood flow (CBF) using arterial spin labeling MRI between day 4 life (DOL4) and 11 (DOL11) neonates with hypoxic-ischemic encephalopathy (HIE) treated hypothermia. secondary objectives were compare CBF values the different regions interest (ROIs) infants ischemic lesions on normal findings. We prospectively included all consecutive HIE admitted neonatal intensive care unit our institution who eligible for therapeutic...
Monogenic early onset osteoporosis (EOOP) is a rare disease defined by low bone mineral density (BMD) that results in increased risk of fracture children and young adults. Although several causative genes have been identified, some the EOOP causation remains unresolved. Whole-exome sequencing revealed de novo heterozygous loss-of-function mutation Wnt family member 11 (WNT11) (NM_004626.2:c.677_678dup p.Leu227Glyfs*22) 4-year-old boy with BMD fractures. We identified two WNT11 missense...
Osteonecrosis (ON) is a known complication of acute leukemia (AL) management, affecting 1%-10% young patients and resulting in long-term morbidity. Widespread access to MRI over the past decade has allowed earlier detection more accurate assessment. This study investigated clinical features 129 (2.5%) with symptomatic ON retrospectively recruited from French LEA (Leucémies de l'Enfant et l'Adolescent, or child adolescent leukemias) cohort (n = 4,973). We analyzed data concerning risk...
To investigate the feasibility of diffusion-weighted magnetic resonance imaging (DW-MRI) as a predictive marker after neoadjuvant chemotherapy in patients with rhabdomyosarcoma.We performed multicenter retrospective study including pediatric, adolescent and young adult rhabdomyosarcoma, Intergroup Rhabdomyosarcoma Study group III/IV, treated according to European paediatric Soft tissue sarcoma Group (EpSSG) RMS2005 or MTS2008 studies. DW-MRI was institutional protocols. We two-dimensional...
Background. Osteonecrosis (ON) is a long-known complication of acute leukemia (AL) management affecting 1 to 10% young patients, leading long-term morbidity. Widespread access Magnetic Resonance Imagery (MRI) over the past ten years has allowed earlier detection and more accurate assessment. This study investigated clinical radiological features ON, among large French cohort L.E.A (Leucémie Enfant Adolescent) Procedure. Patients with ON were retrospectively enrolled risk factors for onset,...