A5006518748- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cardiac tumors and thrombi
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Childhood Cancer Survivors' Quality of Life
- Bone Tumor Diagnosis and Treatments
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Cytomegalovirus and herpesvirus research
- Neuroblastoma Research and Treatments
- Cancer survivorship and care
- Management of metastatic bone disease
- Herpesvirus Infections and Treatments
- Surgical site infection prevention
- Palliative Care and End-of-Life Issues
- RNA Interference and Gene Delivery
- Testicular diseases and treatments
- Chemotherapy-induced organ toxicity mitigation
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Parvovirus B19 Infection Studies
- Congenital Diaphragmatic Hernia Studies
- Spinal Dysraphism and Malformations
Princess Máxima Center
2019-2025
Emma Kinderziekenhuis
2014-2021
University of Amsterdam
2021
Amsterdam University Medical Centers
2021
Amsterdam UMC Location University of Amsterdam
2014-2019
Wilhelmina Children's Hospital
2002-2013
University Medical Center Utrecht
2002-2010
University of California, San Diego
2005-2006
Ewing 2008R3 was conducted in 12 countries and evaluated the effect of treosulfan melphalan high-dose chemotherapy (TreoMel-HDT) followed by reinfusion autologous hematopoietic stem cells on event-free survival (EFS) overall high-risk sarcoma (EWS).Phase III, open-label, prospective, multicenter, randomized controlled clinical trial. Eligible patients had disseminated EWS with metastases to bone and/or other sites, excluding only pulmonary metastases. Patients received six cycles...
Background Ewing sarcoma (EWS) of the head and neck is rare. Multimodal treatment consists chemotherapy local treatment; however, for EWS challenging. The first objective was to describe administered patients with localized according EURO‐E.W.I.N.G.99‐trial, assess impact on survival. second systematically review scientific literature available this topic. Procedure Fifty‐one were included. Local control consisted surgery and/or radiotherapy (RT). Event‐free survival (EFS) overall (OS)...
ABSTRACT Background Pediatric cancer survivors can experience neuropsychological problems in the long term. Less is known about performance and its possible predictors early treatment phase of non‐central nervous system (CNS) cancers. Procedure This study describes 104 children with leukemia ( n = 43), lymphoma 29), or a non‐CNS solid tumor 33) aged 5–18 years at diagnosis M 11.78, SD 3.71, 48% female), 4.52 months (SD 0.77) after diagnosis. Using one‐sample t ‐tests, measures IQ, attention,...
Bone sarcoma patients face intensive treatment, including life-changing local therapy, which impacts both short- and long-term functioning. Moreover, bone survivors experience the highest burden of adverse events all childhood cancer survivors. To address these issues, we set up a structured multidisciplinary outpatient follow-up clinic for who completed treatment integrated this into standard care. This study protocol describes methodology cross-sectional that aims to systematically report...
Osteosarcoma is a challenging disease requiring multidisciplinary management in expert centers for optimal outcome. There are no current international protocols or guidelines specific pediatric and adolescent osteosarcoma. The European Standard Clinical Practice (ESCP) project collaboration between ERN PaedCan SIOP Europe's Trial Groups to develop approved clinical recommendations reflecting best practice. This manuscript summary of the full ESCP guideline patients with provides evidence...
Abstract Objective To investigate the prognostic value of baseline European Association Nuclear Medicine Research Ltd. (EARL) standardized [ 18 F]fluorodeoxyglucose positron emission tomography-computed tomography ([ F]FDG PET-CT) quantitative values for survival and to evaluate cutoff identified in other studies. Materials methods Pediatric adolescent patients with high-grade osteosarcoma were included. Baseline PET-CT, EARL-accredited reconstructions, was standard diagnostic staging...
Abstract Karyomegalic interstitial nephropathy (KIN) has been reported as an incidental finding in patients with childhood cancer treated ifosfamide. It is defined by the presence of tubular epithelial cells (TECs) enlarged, irregular, and hyperchromatic nuclei. Cellular senescence proposed to be involved kidney fibrosis hereditary KIN patients. We report that could diagnosed 7–32 months after diagnosis 6/6 consecutive biopsied for progressive chronic disease (CKD) unknown cause between 2018...
Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive the only predictor for HAdV DNAemia after (P < .001). a alloreactive disease. Early detection and intervention might help to prevent disease transplantation.
The phase III, open-label, prospective, multicenter, randomized Ewing 2008R1 trial (EudraCT2008-003658-13) was conducted in 12 countries to evaluate the effect of zoledronic acid (ZOL) maintenance therapy compared with no add-on regarding event-free survival (EFS, primary endpoint) and overall (OS) standard-risk sarcoma (EWS).
(1) Background: Younger age has been associated with better overall survival (OS) in Ewing sarcoma (ES), especially under the of 10. The favorable younger patients underlines need for minimizing treatment burden and late sequelae. Our study aimed at describing clinical characteristics, outcome a cohort ES aged 0−10. (2) Methods: In this retrospective multicenter study, all consecutive 0−10, treated four centers Netherlands (n = 33) one Spain 27) between 1982 2008, minimum follow-up 10 years,...
Radiation therapy (RT) is an integral part of Ewing sarcoma (EwS) therapy. The 2008 protocol recommended RT doses ranging from 45 to 54 Gy. However, some patients received other RT. We analyzed the effect different on event-free survival (EFS) and overall (OS) in with EwS.The database included 528 RT-admitted nonmetastatic EwS. Recommended multimodal consisted multiagent chemotherapy local treatment consisting surgery (S&RT group) and/or (RT group). EFS OS were uni- multivariable Cox...
Abstract Background Magnetic resonance imaging ( MRI ) is the modality of choice for local staging and response evaluation Ewing sarcoma (EwS). Aim this study was to determine relevance tumor volume TVR in relation histological (HisRes) survival, order evaluate if early modification chemotherapy might be indicated patients with inadequate . Methods Three dimensional (3D)‐tumor data at diagnosis, during induction phase (1‐3 courses chemotherapy; n = 195) and/or late (4‐6 courses; 175) from...
Background. Ewing sarcoma (EwS) is a rare and highly malignant bone tumor primarily affecting children, adolescents, young adults. The pelvis, trunk, lower extremities are the most common sites, while EwS of sacrum as primary site very rare, only few studies focusing on this location published. Due to anatomical condition, local treatment challenging in sacral malignancies. We analyzed factors that might influence outcome patients suffering from EwS. Methods. retrospectively data GPOH...
Children and young adults needing surgery for a primary malignant bone tumour around the knee face difficult, life-changing decision. A previous study showed that this population wants to be involved more in decision-making process involvement leads less decisional stress regret. Therefore, well-designed standardized based on principles of shared needs designed, implemented, evaluated.
Adenovirus can cause fatal infections in the immunocompromised host. To date, no effective anti-viral therapy is available. Adoptive with adenovirus-specific T cells could be a promising treatment, but requires identification of such cells. Aim this study was to identify conserved adenoviral cell epitopes recognized majority healthy individuals. By using computer algorithm designed predict pan-HLA-DR-binding epitopes, we selected 19 peptides adenovirus serotype 5. PBMCs from 26 subjects were...
Summary Several T cell abnormalities have been described in common variable immunodeficiency (CVID), a B disorder of mainly unknown origin. A subset CVID patients suffers from frequent reactivations herpes viruses. We studied function [and paediatric with specific antibody deficiency (SAD)] by measuring proliferation and cytokine production response to virus-antigens (n = 9) SAD 5), adult 14) healthy controls. Paediatric patients, but not displayed moderately increased CD8+ cytomegalovirus,...