A5077874845- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Lymphoma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Acute Lymphoblastic Leukemia research
- HIV/AIDS drug development and treatment
- Drug Transport and Resistance Mechanisms
- Acute Myeloid Leukemia Research
- Neuroendocrine Tumor Research Advances
- Neonatal and fetal brain pathology
- CNS Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Folate and B Vitamins Research
- Blood disorders and treatments
- Migraine and Headache Studies
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Neuroblastoma Research and Treatments
- Bone and Joint Diseases
- Biochemical and Molecular Research
- Soft tissue tumor case studies
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Oral health in cancer treatment
University of Padua
2019-2023
University of Turin
2010-2019
Assistance Publique – Hôpitaux de Paris
2014-2017
Université Paris Cité
2014-2017
Délégation Paris 7
2014-2017
Inserm
2014-2017
Sorbonne Paris Cité
2015-2017
Ospedale San Luigi Gonzaga
2012-2016
PremUP
2015
Centre de Recherche de l'Institut de Démographie de l'Université Paris 1
2015
Deferiprone (DFP) has been evaluated in a wide range of disorders, but most data come from transfusion‐dependent thalassemia. The safety and tolerability profile includes gastrointestinal complaints, liver enzymes elevation, weight gain, arthropathy, neutropenia, agranulocytosis. last requires close monitoring blood count precludes the use DFP conditions with bone marrow abnormalities. efficacy is similar among three available chelators. For DFP, choice dosage crucial to optimize effect on...
We evaluated deferasirox pharmacokinetic according to SNPs in genes involved its metabolism and elimination. Moreover, we defined a plasma area under the curve cut-off value predicting therapy response.Allelic discrimination was performed by real-time PCR. Drug concentrations were measured high performance liquid chromatography system coupled with an ultraviolet method.Pharmacokinetic parameters significantly influenced UGT1A1 rs887829C>T, UGT1A3 rs1983023C>T rs3806596A>G SNPs. Area values...
Background Migraine is a common cause of headache in childhood. Several studies have investigated the association between migraine and atopic diseases, mostly adult population. Objective This study aimed to investigate this children. Methods A case‐control was conducted across 3 European tertiary care hospitals June 2014 August 2014. Cases (n = 229) were children aged 6‐18 years consulting for episode. Controls same age range 406) minor injury did not history recurrent headache. Logistic...
Pediatric oncohematologic patients are a high-risk population for clinical deterioration that might require pediatric intensive care unit (PICU) admission. Several studies have described outcomes and mortality predictors post hematopoietic stem cell transplantation (HSCT), but fewer data exist regarding the category of non-HSCT patients.All ≤18 years requiring PICU admission from 1998 to 2015 in our tertiary-care academic hospital were retrospectively evaluated by means hematology-oncology...
We aimed to evaluate the influence of genetic polymorphisms involved in deferasirox metabolism and transport on its pharmacokinetics treatment toxicity, a cohort β-thalassaemic children.Drug plasma concentrations were measured by HPLC-UV method. Allelic discrimination for UGT1A1, UGT1A3, CYP1A1, CYP1A2, CYP2D6, MRP2 BCRP1 was performed real-time PCR.CYP1A1 rs2606345AA influenced Ctrough (p = 0.001) t1/2 0.042), CYP1A1 rs4646903TC/CC 0.005) rs2231142GA/AA Tmax CYP2D6 rs1135840CG/GG Cmax...
Brentuximab vedotin (BV) is an antibody drug-conjugated anti-CD30 approved for the treatment of adult classical Hodgkin's lymphoma (HL), whereas it considered as off-label indication in paediatrics. The aim study was to evaluate safety and efficacy BV treat patients aged less than 18 years with refractory/relapsed HL.In this multicentre, retrospective study, 68 paediatric who received at least one dose between November 2011 August 2020 were enrolled. A median nine doses administered...
Deferasirox adverse effects include the following: gastrointestinal disturbance, mild elevations in serum creatinine levels and intermittent proteinuria; these events are dose-dependent reversible with drug discontinuation, but this solution can lead to an inadequate iron chelation. For reasons, interindividual variability of plasma concentration could help clinical management deferasirox dosage. We sought describe exposure a cohort 60 adult patients.A fully validated chromatographic method...
Patients with β-thalassemia major have extremely low vitamin D levels, owing to reduced intestinal absorption, subicteric tint, and/or iron-induced higher pigmentation. We investigated whether some polymorphisms within the VDR, CYP24A1, CYP27B1, and GC genes could play a role in deferasirox pharmacokinetics cohort of pediatric patients.Eighteen children were enrolled. Drug plasma concentrations at end dosing interval (Ctrough) after 0, 2, 4, 6, 24 h drug administration measured by HPLC-UV...
Iron chelation in the transfusion-dependent anaemias management is essential to prevent end-organ damage and improve survival. Deferasirox a once-daily orally active tridentate selective iron chelator which pharmacokinetic disposition could influence treatment efficacy toxicity. Therapeutic drug monitoring an important tool for optimizing utilization doses.A fully validated chromatographic method was used quantify deferasirox concentration plasma collected from paediatric patients with...
Hodgkin's lymphoma (HL) is one of the neoplasms with best prognosis in children, adolescents and young adults, but sufferers are burdened by possibility developing adverse effects such as Bone Ischemic Lesions (BILs) which lesions bone caused loss of/reduction blood flow. The main goal this retrospective study was to evaluate role [18F]FDG-PET-MR early detection BILs a single-center cohort uniformly treated pediatric HL patients. were assessed through PET-MR images appearance medullary...
Objectives Iron-burden-induced arrhythmia and heart failure are among the leading causes of morbidity mortality in β-thalassaemia major patients. T2* cardiac magnetic resonance remains only reliable noninvasive method for iron excess assessment. We explored role single nucleotide polymorphisms involved vitamin D metabolism, transport activity deferasirox (DFX) metabolism on burden. Patients methods One hundred five patients, treated with DFX, were enrolled present study. Drug plasma Ctrough...
Abstract Aims Classic Hodgkin lymphoma (cHL) is a common malignancy of the pediatric age. Although clinical‐radiological features are routinely used for disease risk stratification, role tumor histology has yet to be defined. This study aimed characterize clinical‐pathological large cohort cHL specifically investigating relevance prognostic stratification patients. Methods and results The considered 96 clinically annotated cases treated according AIEOP‐LH2004 protocol. following histological...
Malignant histiocytoses (MHs) are a group of accessory cell-derived neoplasms, traditionally sub-classified into histiocytic sarcoma, interdigitating cell Langerhans (LC) sarcoma and ...
Diffuse large B-cell Lymphoma (DLBCL) secondary to a chronic severe Epstein-Barr virus (EBV) infection has not been previously described in patient with trisomy 21. Here we report the case of 14-year-old girl 21 impaired control EBV and DLBCL. She was cured dose-adapted chemotherapy hematopoietic stem cell transplantation without treatment-related toxicity. We describe first EBV-positive DLBCL propose treatment modality for this rare entity.