A5081068826- Circadian rhythm and melatonin
- Heme Oxygenase-1 and Carbon Monoxide
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
- Pain Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Sirtuins and Resveratrol in Medicine
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Mitochondrial Function and Pathology
- Head and Neck Surgical Oncology
- Cardiovascular Health and Disease Prevention
- Heavy Metal Exposure and Toxicity
- Endoplasmic Reticulum Stress and Disease
- Neuropeptides and Animal Physiology
- Atherosclerosis and Cardiovascular Diseases
- Meningioma and schwannoma management
- Alcohol Consumption and Health Effects
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Periodontal Regeneration and Treatments
University of Brescia
2016-2025
Italian Society of Physiotherapy
2021-2024
Medica (Italy)
2016
New York Medical College
2009-2015
Marshall University
2014
University of Catania
2014
National Institute of Environmental Health Sciences
2014
National Institutes of Health
2014
Brescia University
1994-2011
Rockefeller University
2009-2010
OBJECTIVE—We hypothesized that the induction of heme oxygenase (HO)-1 and increased HO activity, which induces arterial antioxidative enzymes vasoprotection in a mouse rat model diabetes, would ameliorate insulin resistance, obesity, diabetes ob type 2 diabetes. RESEARCH DESIGN AND METHODS—Lean mice were intraperitoneally administered HO-1 inducer cobalt protoporphyrin (3 mg/kg CoPP) with without inhibitor stannous mesoporphyrin (2 mg/100 g SnMP) once week for 6 weeks. Body weight, blood...
Alopecia areata (AA) is a common autoimmune condition, causing inflammation-induced hair loss. This disease has very limited treatment possibilities, and no either curative or preventive. Platelet-rich plasma (PRP) emerged as new modality in dermatology, preliminary evidence suggested that it might have beneficial role growth.To evaluate the efficacy safety of PRP for AA randomized, double-blind, placebo- active-controlled, half-head, parallel-group study.Forty-five patients with were...
Among cardiovascular diseases, hypertension is one of the main risk factors predisposing to fatal complications. Oxidative stress and chronic inflammation have been identified as potentially responsible for development endothelial damage vascular stiffness, two primum movens diseases. Based on these data, we conducted an open-label randomized study, first, evaluate stiffness in hypertense patients; second, test effect supplementation with a physiological antioxidant (melatonin 1 mg/day year)...
Background— In endothelial cells, caveolin-1, the structural protein of caveolae, acts as a scaffolding to cluster lipids and signaling molecules within caveolae and, in some instances, regulates activity proteins targeted caveolae. Specifically, different putative mediators endothelium-derived hyperpolarizing factor (EDHF)–mediated relaxation are located and/or regulated by such potassium channels, calcium regulatory proteins, connexin 43, molecular component gap junctions. Methods Results—...
Obesity-associated inflammation causes insulin resistance. Obese adipose tissue displays hypertrophied adipocytes and increased expression of the cannabinoid-1 receptor. Cobalt protoporphyrin (CoPP) increases heme oxygenase-1 (HO-1) activity, increasing adiponectin reducing inflammatory cytokines. We hypothesize that CoPP administration to Zucker diabetic fat (ZDF) rats would improve sensitivity remodel tissue. Twelve-week-old lean ZDF were divided into 4 groups: lean, lean–CoPP, ZDF,...
The main neuropathological features of Parkinson's disease are dopaminergic nigrostriatal neuron degeneration, and intraneuronal intraneuritic proteinaceous inclusions named Lewy bodies neurites, respectively, which mainly contain α-synuclein (α-syn, also known as SNCA). neuronal phosphoprotein synapsin III (also SYN3), is a pivotal regulator dopamine synaptic function. Here, we show that α-syn interacts with modulates III. absence causes selective increase redistribution III, changes the...
Melatonin, an indole produced by pineal and extrapineal tissues, but also taken with a vegetarian diet, has strong anti-oxidant, anti-inflammatory anti-obesogenic potentials. Non-alcoholic fatty liver disease (NAFLD) is the hepatic side of metabolic syndrome. NAFLD still reversible phase may evolve into steatohepatitis (NASH), cirrhosis carcinoma. Currently, effective therapy for blocking staging lacking. Silent information regulator 1 (SIRT1), NAD+ dependent histone deacetylase, modulates...
Increases in visceral fat are associated with increased inflammation, dyslipidemia, insulin resistance, glucose intolerance, and vascular dysfunction. We examined the effect of potent heme oxygenase (HO)-1 inducer, cobalt protoporphyrin (CoPP), on regulation adiposity levels both female male obese mice. Both lean mice were administered CoPP intraperitoneally (3 mg/kg once per week) for 6 weeks. Serum adiponectin, tumor necrosis factor α (TNFa), interleukin (IL)-1β IL-6, HO-1, PPARγ, pAKT,...
Critically ill patients exhibit reduced melatonin secretion, both in nocturnal peaks and basal daytime levels. Oral supplementation may be useful for known sedative antioxidant properties. Its early enteral absorption daily pharmacokinetics were determined two cohorts of six high-risk this prospective trial. During their third fourth Intensive Care Unit (ICU) day, they underwent different sets repeated blood samples to detect serum levels through radio-immuno-assay. Cohort 1: taken at 20:00,...
Objective Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased media-to-lumen ratio subcutaneous small resistance arteries has been demonstrated to predict development cardiocerebrovascular events hypertensive patients. Alterations structure cerebral have animal models experimental or genetic hypertension. However, no evaluation with reliable techniques ever performed humans. Design and methods Twenty-eight participants were...