A5047638660- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Cardiovascular Health and Disease Prevention
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- Antioxidant Activity and Oxidative Stress
- Lipoproteins and Cardiovascular Health
- Autism Spectrum Disorder Research
- Pharmacological Effects of Natural Compounds
- Inflammasome and immune disorders
- Exercise and Physiological Responses
- Renal Diseases and Glomerulopathies
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Spaceflight effects on biology
- Reproductive System and Pregnancy
University of Bologna
2021-2025
University of Brescia
2015-2024
Italian Society of Physiotherapy
2021-2023
University of Catania
2007-2023
Among cardiovascular diseases, hypertension is one of the main risk factors predisposing to fatal complications. Oxidative stress and chronic inflammation have been identified as potentially responsible for development endothelial damage vascular stiffness, two primum movens diseases. Based on these data, we conducted an open-label randomized study, first, evaluate stiffness in hypertense patients; second, test effect supplementation with a physiological antioxidant (melatonin 1 mg/day year)...
Melatonin is known to exert antitumour activity in several types of human cancers, but the underlying mechanisms as well efficacy different doses melatonin are not defined. Here, we test hypothesis whether nanomolar range effective exerting vivo and examine correlation with hypoxia signalling mechanism, which may be a major molecular mechanism by antagonizes cancer. To this hypothesis, LNCaP prostate cancer cells were xenografted into seven-wk-old Foxn1nu/nu male mice that treated (18 i.p....
Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain and an extensive array of other symptoms including disordered sleep, fatigue, depression anxiety. Important factors involved in the pathogenic process fibromyalgia are inflammation oxidative stress, suggesting that ant-inflammatory and/or antioxidant supplementation might be effective management modulation this syndrome. Recent evidence suggests melatonin may suitable for purpose due to its well known...
Lupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). NLRP3 inflammasome activation implicated in LN pathogenesis, suggesting its potential targets for treatment. Melatonin, an endogenous indoleamine, considered important multitasking molecule that has been reported to have anti-inflammatory effects inhibiting nuclear factor-kappa B (NF-κB)-mediated responses vivo. This also protective against the of inflammasomes and, particular, inflammasome....
Irritable bowel syndrome (IBS) is a multifactorial condition with heterogeneous pathophysiology, including intestinal permeability alterations. The aim of the present study was to assess ability probiotic blend (PB) consisting two Lactiplantibacillus plantarum strains (CECT7484 and CECT7485) one strain Pediococcus acidilactici (CECT7483) recover increase induced by mediators from IBS mucosal biopsies highlight underlying molecular mechanisms. Twenty-one patients diagnosed according ROME IV...
Large water fluxes continuously take place between the different compartments of brain as well parenchyma and blood or cerebrospinal fluid.Disturbances in this well-regulated homeostasis may have deleterious effects on function be fatal cases where accumulates following pathologies such ischemia, haemorrhage, trauma.The molecular pathways by which molecules cross barrier are not well-understood, although discovery Aquaporin 4 (AQP4) improved understanding some these transport processes,...
Lupus nephritis (LN) is one of the most severe complications systemic lupus erythematosus. As murine models LN are valuable tools to better understand its pathophysiology and search for new effective treatments, we investigated effects bioflavonoid quercetin on pristane-induced mice through histomorphological analyses.Immunofluorescence biochemical assays were used evaluate expression markers inflammation (interleukin-6, IL-6; tumour necrosis factor-α, TNF-α), oxidative stress (catalase,...
Fibromyalgia syndrome (FMS) is considered a musculoskeletal disorder associated to other symptoms including chronic pain. Since the hypothesis of FMS etiogenesis consistent with mitochondrial dysfunction and oxidative stress, we evaluated pathophysiological correlation among these factors studying some proteins involved in homeostasis. We focused our attention on roles peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α), mitofusin2 (Mfn2), coenzyme Q10 (CoQ10)...
Aim: Obesity is associated with metabolic syndrome, hypertension, dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. In this study, we investigated whether the dietary supplementation of pomegranate seed oil (PSO) exerted a protective effect on lipid uptake, fibrosis, mitochondrial function in mouse model obesity insulin resistance. Method: vivo eight-week-old C57BL/6J male mice were fed high fat diet (HFD) for 24 weeks then divided into three groups as follows:...
Abstract: Melatonin, the chief product secreted by pineal gland, is capable of reducing free radical damage acting directly as a scavenger, and indirectly, stimulating antioxidant enzymes. Cyclosporine A (CsA) most widely used immunosuppressive drug, but its therapeutic use has several side effects including, i.e. nephrotoxicity cardiotoxicity. This study was designed to examine beneficial melatonin in preventing CsA‐induced Additionally, we investigated ability protect rat heart via...
It was suggested that oxidative stress has a key role in the development of endothelial dysfunction, as well microvascular structural alterations. Therefore, we have investigated 2 substances with antioxidant properties: melatonin and Pycnogenol. We treated 7 spontaneously hypertensive rats (SHRs) Pycnogenol for 6 weeks. compared results obtained those observed SHRs Wistar-Kyoto normotensive control kept untreated. Mesenteric small resistance arteries were dissected mounted on wire myograph,...
It is not known whether, in obesity, the capillary density or number of circulating endothelial progenitor cells (EPCs) are reduced, whether fibrosis small vessels also present. In addition, possible effects weight reduction on these parameters have never been evaluated. Therefore, we investigated EPCs and 25 patients with severe all submitted to bariatric surgery, 18 normotensive lean subjects 12 hypertensive as controls. All underwent a biopsy subcutaneous fat during surgery. five...