A5103119612- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Vasculitis and related conditions
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Organ Donation and Transplantation
- Cardiovascular and exercise physiology
- Iron Metabolism and Disorders
- Nitric Oxide and Endothelin Effects
- Autoimmune Bullous Skin Diseases
- Genetic and Kidney Cyst Diseases
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Complement system in diseases
- Pregnancy and Medication Impact
Universidade Federal do Rio Grande do Sul
2015-2024
Hospital de Clínicas de Porto Alegre
2014-2023
Massachusetts General Hospital
2007
Steroid-resistant focal segmental glomerulosclerosis (SR-FSGS) is a common glomerulopathy associated with nephrotic range proteinuria. Treatment goals are reduction in proteinuria, which can delay end-stage renal disease.Patients SR-FSGS were enrolled randomized, double-blind placebo-controlled trial of fresolimumab, monoclonal anti-transforming growth factor-β antibody, at 1 mg/kg or 4 for 112 days, followed 252 days (NCT01665391). The primary efficacy endpoint was the percentage patients...
Patients on hemodialysis (HD) show changes in muscle structure and function reducing their functional capacity. This study was conduted to assess the effects of respiratory training (RMT) peripheral (PMT) during dialysis parameters, inflammatory state, quality life (QoL) patients HD. Randomized controlled trial included 39 HD, they were divided into three groups: RMT (n = 11), PMT 14), controls (C, n 14). Training performed HD session for 10 weeks. Maximal inspiratory pressure (PImax),...
Diabet. Med. 28, 90–95 (2011) Abstract Aims To analyse the performances of Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) and Modification Diet in Renal (MDRD) study equations to estimate glomerular filtration rate (GFR) patients with Type 2 diabetes mellitus GFRs >60 ml/min healthy volunteers. Methods This cross‐sectional included 111 individuals (56 55 volunteers), aged 58 ± 9 years; 54 were men (49%) ninety‐eight (88%) white. Glomerular was measured by 51 Cr‐EDTA...
Lupus nephritis (LN) is a kidney inflammatory disease caused by systemic lupus erythematosus (SLE). NLRP3 inflammasome activation implicated in LN pathogenesis, suggesting its potential targets for treatment. Melatonin, an endogenous indoleamine, considered important multitasking molecule that has been reported to have anti-inflammatory effects inhibiting nuclear factor-kappa B (NF-κB)-mediated responses vivo. This also protective against the of inflammasomes and, particular, inflammasome....
Abstract: The Banff classification for kidney allograft pathology has proved to be reproducible, but its inter and intraobserver agreement can vary substantially among centres. aim of this study was evaluate reproducibility surveillance renal biopsies pathologists from different transplant This included 32 patients with stable graft function. Biopsies were performed 2 12 months post‐transplant. Histology interpreted according the schema by three pathologists, measured. best obtained presence...
The aim of this study was to report the prevalence and mortality associated with anticoagulant-related nephropathy (ARN) through a systematic review literature.Electronic searches were conducted in Medline EMBASE databases, manual performed reference lists identified studies. studies selected by two independent researchers, first evaluating titles abstracts then reading complete texts Case series, cross-sectional studies, cohort case-control reporting factors ARN selected. methodological...
Lupus nephritis (LN) is one of the most severe complications systemic lupus erythematosus. As murine models LN are valuable tools to better understand its pathophysiology and search for new effective treatments, we investigated effects bioflavonoid quercetin on pristane-induced mice through histomorphological analyses.Immunofluorescence biochemical assays were used evaluate expression markers inflammation (interleukin-6, IL-6; tumour necrosis factor-α, TNF-α), oxidative stress (catalase,...
Urinary biomarkers can predict the progression of chronic kidney disease (CKD). In this study, injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and N-acetyl-β-D-glucosaminidase (NAG) were correlated with stages CKD, association these CKD adverse outcomes was determined. A total 250 patients, including 111 on hemodialysis, studied. KIM-1, NGAL, NAG measured at baseline. Patients not dialysis baseline who progressed to a worse stage compared those did progress. The...
Abstract The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation seems to correct the overdiagnosis of chronic kidney disease (CKD) provided by Modification Diet in Renal (MDRD) equation. However, this point has not been tested some ethnic groups. This study investigated performance MDRD and CKD-EPI equations South Brazilian individuals. cross-sectional included 354 individuals including healthy volunteers, diabetic non-diabetic with or without CKD. Glomerular filtration...
Abstract Background To investigate gene expression of podocyte-specific proteins in urine diabetes and prediabetes subjects the association these with albuminuria. Methods Fifteen controls, 19 prediabetes, 67 were included. Messenger RNA nephrin, podocin, podocalyxin, synaptopodin, TRPC6, alpha-actinin-4, TGF-β 1 measured using RT-PCR. Podocyte marker was correlated albuminuria, glycemic control, renal function. The diagnostic performance genes used to detect increased albuminuria assessed...
Background: Endothelin-1 (ET-1) is associated with progression of renal disease, acting as a vasoconstrictor and growth factor for mesangial cells. ET-1 endothelin A receptor (ET-RA) might have role in the development diabetic nephropathy (DN). The aims this study were to determine ET-RA expressions patients DN correlate these function proteinuria. Materials methods: This cross-sectional comprising 13 type 2 diabetes mellitus DN, 10 proteinuric IgA nephropathy, samples normal kidney from...
INTRODUCTION: Malnutrition is multifactorial and may be modified by nutritional intervention. We aimed to assess the impact of an intervention on status malnourished hemodialysis patients their acceptance a non-industrialized supplement. METHODS: 18 were studied, they selected from previous assessment where risk was defined as: subjective global > 15 plus one criterion for malnutrition. The following variables assessed: anthropometric parameters, assessment, dietary intake, six-minute...
Kidney injury molecule-1 (KIM-1) is expressed in tubular epithelial cells after and may have a role the development of renal graft fibrosis. In this study we evaluated molecular protein expressions KIM-1 dysfunctional allografts also mRNA expression urine as potential biomarkers Protein levels tissue urinary sediment 69 kidney transplant recipients that undertook for-cause biopsies were by immunohistochemistry real-time polymerase chain reaction. The histopathology was classified according...
Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging a public health challenge worldwide. Levamisole-associated toxicity manifests clinically systemic vasculitis, consisting cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, less commonly crescentic nephritis have described association with anti-neutrophil cytoplasmic antibodies (ANCAs) other autoantibodies. Here we...
Introduction: Hemodialysis contributes to increased oxidative stress and induces transitory hypoxemia. Compartmentalization decreases the supply of solutes dialyzer during treatment. The aim this study was investigate acute effects intradialytic aerobic exercise on solute removal, blood gases in patients with chronic kidney disease a single hemodialysis session. Methods: Thirty were randomized perform cycle ergometer for lower limbs 30 minutes intensity between 60-70% maximal heart rate, or...
Renal fibrosis is the result of interaction cellular and molecular pathways, which induced by sustained glomerular injury involves podocytes multiple profibrotic factors. In this study, we investigated correlation mRNA expression podocyte proteins factors with renal measured in biopsies patients primary secondary glomerulopathies.
Abstract Background Cardiorespiratory fitness seems to play an important role in the general health of patients undergoing hemodialysis (HD). However, prediction peak oxygen uptake (V̇O 2peak ) a clinical setting is not widely adopted for these patients. Objectives Evaluate agreement and reliability between directly indirectly V̇O measurements HD. Methods This cross-sectional study with HD that performed cardiopulmonary exercise test (CPET) 5/10 watts incremental load each minute using cycle...
Vascular cell adhesion molecule-1 (VCAM-1) is involved in the progression of glomerular and tubulointerstitial injury lupus nephritis (LN) can be easily assessed urine. The aim this study was to assess urinary soluble VCAM-1 (uVCAM-1) as a biomarker disease activity treatment response LN.This prospective enrolled 62 patients with class III, IV or V LN diagnosed within last 3 years divided them two groups: without active at inclusion, each group 31 patients. At visit, urine sample collected...