A5048466377- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Healthcare Regulation
- Diabetes and associated disorders
- Coconut Research and Applications
- Blood Pressure and Hypertension Studies
- Transcranial Magnetic Stimulation Studies
- COVID-19 Clinical Research Studies
- Health and Lifestyle Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Pharmacology and Obesity Treatment
- Healthcare during COVID-19 Pandemic
- Regulation of Appetite and Obesity
- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
Universidade Federal do Rio Grande do Sul
2015-2024
Hospital de Clínicas de Porto Alegre
2015-2024
Universidade Federal do Rio Grande
2022
University of Washington
2006-2013
VA Puget Sound Health Care System
2006-2009
United States Department of Veterans Affairs
2007
Harborview Medical Center
2006
To evaluate the effect of treatment with dipeptidyl peptidase (DPP)-4 inhibitor vildagliptin on insulin sensitivity and beta-cell function in subjects impaired fasting glucose (IFG).A total 22 IFG (11 female 11 male, mean +/- SD age 59.6 11.5 years) were treated orally 100 mg once daily a single-blind study. Subjects received placebo for 2 weeks (run-in) followed by 6 (treatment) then (washout). A frequently sampled intravenous tolerance test (FSIGT), 2-h meal (MTT), was performed at 2, 8,...
Diabetic nephropathy is the leading cause of chronic renal disease and a major cardiovascular mortality. has been categorized into stages: microalbuminuria macroalbuminuria. The cut-off values micro- macroalbuminuria are arbitrary their have questioned. Subjects in upper-normal range albuminuria seem to be at high risk progression or they also had higher blood pressure than normoalbuminuric subjects lower normoalbuminuria range. screening made by measuring albumin spot urine. If abnormal, it...
Although advanced age, male sex, and some comorbidities impact the clinical course of COVID-19, these factors only partially explain inter-individual variability in disease severity. Some studies have shown that genetic polymorphisms contribute to COVID-19 severity; however, results are inconclusive. Thus, we investigated association between ACE1, ACE2, DPP9, IFIH1, IFNAR2, IFNL4, TLR3, TMPRSS2, TYK2 COVID-19. A total 694 patients with were categorized as: (1) ward inpatients (moderate...
There is evidence for genetic predisposition to diabetic nephropathy in type 1 patients. However, there are few studies on 2 patients, and most of those have been conducted ethnic minorities or Caucasian individuals. The aim this study was ascertain the presence an inherited a sample Brazilian Families with two more siblings were identified. Subjects longest duration known diabetes considered probands. Some 90 probands their 107 studied. Urinary albumin excretion rate measured sterile 24-h...
Although obesity has been, in general, associated with glomerular hyperfiltration, visceral adiposity been suggested to be reduced filtration.The aim of the study was evaluate differential effects and body fat distribution on filtration.We conducted a cross-sectional Japanese-American community Seattle, Washington.We studied representative sample second-generation men women normal glucose tolerance (n = 124) impaired metabolism (impaired fasting and/or tolerance) 144) residing King County,...
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as Nonalcoholic fatty (NAFLD), is one of the most common hepatic diseases in individuals with overweight or obesity. In this context, a panel experts from three medical societies was organized to develop an evidence-based guideline on screening, diagnosis, treatment, and follow-up MASLD. Material methods: A MEDLINE search performed identify randomized clinical trials, meta-analyses, cohort...
The objective of this study was to assess the existence obesity paradox in patients with COVID-19 admitted intensive care unit.
Impaired fasting glucose (IFG) is more prevalent in men and impaired tolerance (IGT) women. To explore whether this sex difference related to female hormones, we performed a cross-sectional analysis of data from 2,164 (1,329 women 835 men) first-degree relatives individuals with type 2 diabetes. Subjects were categorized based on 75-g oral test. Sex hormone replacement therapy (HRT) effects the distribution assessed using multinomial logistic regression corrected for familial clustering....
Chronic inflammation is involved in the pathogenesis of several metabolic diseases, such as obesity and type 2 diabetes mellitus (T2DM). With recent worldwide outbreak coronavirus disease (SARS-CoV-2), it has been observed that individuals with these diseases are more likely to develop complications, increasing severity a poorer outcome. Coronavirus infection leads activation adaptive innate immune responses, resulting massive (to so called cytokine storm), which turn can lead damage various...
To determine whether 1-h oral glucose challenge test (OGCT) or 3-h tolerance (OGTT) results below gestational diabetes mellitus (GDM) criteria are associated with developing diabetes.A retrospective cohort study was performed among women without GDM who had a pregnancy OGCT (n = 24,780) OGTT 6,222). Subsequent ascertained by ICD-9 codes pharmacy laboratory data over median follow-up of 8.8 years.Diabetes risk increased across quartiles: adjusted hazard ratio (HR) 1.67 (95% CI 1.07-2.61) for...