A5040827790- Pancreatic function and diabetes
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- Diabetes Treatment and Management
- Diabetes Management and Research
- Lipid metabolism and disorders
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- T-cell and B-cell Immunology
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Pancreatitis Pathology and Treatment
- Indigenous Health and Education
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- Advanced Glycation End Products research
- Immune responses and vaccinations
- Aldose Reductase and Taurine
- COVID-19 Clinical Research Studies
Hospital de Clínicas de Porto Alegre
2017-2025
Universidade Federal do Rio Grande do Sul
2015-2025
University of Rio Grande and Rio Grande Community College
2023
Hospital de Clínicas
2021
Faculdade de Ciências Médicas de Minas Gerais
2021
Universidade Feevale
2011-2020
United States Food and Drug Administration
1985
Although advanced age, male sex, and some comorbidities impact the clinical course of COVID-19, these factors only partially explain inter-individual variability in disease severity. Some studies have shown that genetic polymorphisms contribute to COVID-19 severity; however, results are inconclusive. Thus, we investigated association between ACE1, ACE2, DPP9, IFIH1, IFNAR2, IFNL4, TLR3, TMPRSS2, TYK2 COVID-19. A total 694 patients with were categorized as: (1) ward inpatients (moderate...
Diabetic kidney disease (DKD) is a common microvascular complication that affects 40% of patients with diabetes mellitus (DM). Emerging evidence suggests role for several microRNAs (miRNAs) in the development DKD. In this context, miR-15a-5p and miR-30e-5p have been shown to regulate expression uncoupling protein 2 (UCP2), mitochondrial decreases reactive oxygen species (ROS) formation by mitochondria. Since ROS overproduction key contributor pathogenesis DKD, dysregulation these two miRNAs...
Autoimmune diseases are characterized by the loss of self-tolerance, leading to immune-mediated tissue destruction and chronic inflammation. Tyrosine kinase 2 (TYK2) protein plays a key role in immunity apoptosis pathways. Studies have reported associations between single nucleotide polymorphisms (SNPs) TYK2 gene autoimmune diseases; however, results still inconclusive. Thus, we conducted systematic review followed meta-analysis. A literature search was performed find studies that...
Single nucleotide polymorphisms (SNPs) in the HLA DR/DQ region have greatest impact on susceptibility to type 1 diabetes mellitus (T1DM). Non-HLA SNPs interact with HLA, influencing risk for T1DM. The aim of this study was develop a genetic score (GRS) based and non-HLA discriminate patients sample comprised 466 T1DM 469 controls. rs689/INS, rs2476601/PTPN22, rs231775/CTLA-4, rs2304256/TYK2, rs2292239/ERBB3, were genotyped using real-time PCR. unweighted GRS (uGRS) calculated by summing...
To investigate the association between rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms diabetic kidney disease in patients with type 2 diabetes mellitus. The sample consisted of 740 mellitus (cases) 303 mellitus, but no (controls). genotyping was conducted using real-time polymerase chain reaction Taqman probes. frequency G/G genotype 16.8% control group 15.7% cases (p = 0.069). After adjusting for covariables, presence G allele associated risk (OR 1.435, 95% CI 1.023 - 2.011; p 0.036),...
Long non-coding RNAs (lncRNAs) are with >200 nucleotides that unable to encode proteins and involved in gene expression regulation. LncRNAs have a key role many physiological pathological processes and, consequently, they been associated several human diseases, including diabetes chronic complications, such as kidney disease (DKD). In this context, some studies identified the dysregulation of lncRNAs MALAT1 TUG1 patients DKD; nevertheless, available data still contradictory. Thus, objective...
The AKR1B1 gene encodes an enzyme that catalyzes the reduction of glucose into sorbitol. Chronic hyperglycemia in patients with diabetes mellitus (DM) leads to increased affinity for and, consequently, sorbitol accumulation. Elevated increases oxidative stress, which is one main pathways related chronic complications diabetes, including diabetic kidney disease (DKD). Accordingly, some studies have suggested rs759853 polymorphism associated DKD; however, findings are still contradictory. aim...
Abstract Background and purpose MicroRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression. MiRNA‐126 miRNA‐146a have been described as having abnormal expressions in diabetic retinopathy (DR) patients. Polymorphisms genes codifying miRNAs (miRSNPs) may alter the expression of corresponding miRNA and, thus, interfere with susceptibility to DR. Therefore, miRSNPs miR‐126 miR‐146a could be associated DR susceptibility. The this study was investigate association between...
Background: Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and pro-inflammatory pathways pancreatic β-cells through modulation of the I interferon signaling pathway. The rs2304256 single nucleotide polymorphism (SNP) TYK2 has been associated with protection different autoimmune diseases. However, to date, only two studies have evaluated association between this SNP T1DM, discordant results. This study...
Objective Type 1 diabetes mellitus (T1DM) is an autoimmune disorder caused by a complex interaction between environmental and genetic risk factors. BTB domain CNC homolog 2 (BACH2) gene encodes transcription factor that acts on the differentiation formation of B T lymphocytes. BACH2 also involved in suppression apoptosis inflammation pancreatic beta-cells, indicating role for it development T1DM. Therefore, aim this study was to evaluate association rs11755527 single nucleotide polymorphism...
Objective: As studies have reported the involvement of angiopoietin-2 (ANGPT-2) in pathogenesis diabetic retinopathy (DR), aim this study was to investigate association between ANGPT-2 rs2442598 polymorphism and DR. Materials methods: This case-control comprised 107 patients with type 1 diabetes mellitus (T1DM) DR (cases) 129 T1DM without (controls) ≥ 10 years DM. The (G/A) genotyped by real-time PCR using TaqMan [...]
The objective of this study was to investigate the association between SNPs in TIE2 and ANGPT-1 genes diabetic retinopathy (DR).This comprised 603 patients with type 2 diabetes mellitus (T2DM) DR (cases) 388 T2DM for more than 10 years without (controls). rs639225 (A/G) rs638203 rs4324901 (G/T) rs2507800 (T/A) were genotyped by real-time PCR using TaqMan MGB probes.The G/G genotype rs639225/TIE2, rs638203/ T allele rs4324901/ANGPT-1 associated protection against after adjustment age,...
The transforming growth factor beta 1 (TGFB1) is a pro-inflammatory cytokine that plays key role in the mechanisms of angiogenesis and breakdown blood-retina barrier, which are implicated pathogenesis diabetic retinopathy (DR). Polymorphisms TGFB1 gene have been associated with DR; however, results still contradictory. Therefore, aim this study was to investigate potential association between two polymorphisms DR. This included 992 patients diabetes mellitus (DM): 546 DR (cases) 446 without...
To investigate the association between long noncoding RNAs (lncRNAs)
Uncoupling protein 2 (UCP2) decreases reactive oxygen species (ROS). ROS overproduction is a key contributor to the pathogenesis of diabetic kidney disease (DKD). Thus, UCP2 polymorphisms are candidate risk factors for DKD; however, their associations with this complication still inconclusive. Here, we describe case-control study and meta-analysis conducted investigate association between -866G/A Ins/Del DKD. The comprised 385 patients type 1 diabetes mellitus (T1DM): 223 without DKD 162...