Karla Laís Pêgas

ORCID: 0000-0002-2374-3144
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About
Contact & Profiles
Research Areas
  • Renal Diseases and Glomerulopathies
  • Glioma Diagnosis and Treatment
  • Renal Transplantation Outcomes and Treatments
  • Sarcoma Diagnosis and Treatment
  • Vascular Tumors and Angiosarcomas
  • Cardiac tumors and thrombi
  • Brain Metastases and Treatment
  • Organ Transplantation Techniques and Outcomes
  • Antifungal resistance and susceptibility
  • Chronic Kidney Disease and Diabetes
  • Fungal Infections and Studies
  • Lipoproteins and Cardiovascular Health
  • Renal and Vascular Pathologies
  • Meningioma and schwannoma management
  • Gastric Cancer Management and Outcomes
  • Genetic factors in colorectal cancer
  • Gastrointestinal Tumor Research and Treatment
  • Venous Thromboembolism Diagnosis and Management
  • Infectious Diseases and Mycology
  • Ear and Head Tumors
  • Actinomycetales infections and treatment
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Acute Myocardial Infarction Research
  • Full-Duplex Wireless Communications
  • Coronary Interventions and Diagnostics

Universidade Federal de Ciências da Saúde de Porto Alegre
2010-2021

Santa Casa Hospital
2007-2020

Grupo Hospitalar Conceição
2020

Hospital Nossa Senhora da Conceição
2014-2020

Hospital de Clínicas de Porto Alegre
2008-2015

Santa Casa de Misericórdia de Marília
2010-2015

University of Health Sciences
2014

Irmandade da Santa Casa de Misericórdia de São Paulo
2008-2014

University of Health Sciences Antigua
2014

Master's College
2014

The Banff working group on preimplantation biopsy was established to develop consensus criteria (best practice guidelines) for the interpretation of kidney biopsies. Digitally scanned slides were used (i) evaluate interobserver variability histopathologic findings, comparing frozen sections with formalin-fixed, paraffin-embedded tissue wedge and needle core biopsies, (ii) correlate findings graft outcome in a cohort biopsies from international medical centers. Intraclass correlations (ICCs)...

10.1111/ajt.13929 article EN cc-by-nc-nd American Journal of Transplantation 2016-06-22

Kidney injury molecule-1 (KIM-1) is expressed in tubular epithelial cells after and may have a role the development of renal graft fibrosis. In this study we evaluated molecular protein expressions KIM-1 dysfunctional allografts also mRNA expression urine as potential biomarkers Protein levels tissue urinary sediment 69 kidney transplant recipients that undertook for-cause biopsies were by immunohistochemistry real-time polymerase chain reaction. The histopathology was classified according...

10.1186/s12882-015-0011-y article EN cc-by BMC Nephrology 2015-02-12

To design an animal model of ischemia-reperfusion (I/R) in kidneys and evaluate the role that predetermined ranges local hypothermia plays on markers stress-oxydative as well histologic sections.Twenty eight male rats Wistar, under general anesthesia, undergone right nephrectomy (G0, control group) followed by left kidney ischemia during 40 min. Four temperatures groups were designed, with seven animals randomized for each group: normothermic (G1, ±37ºC), mild (G2, 26ºC), moderate (G3, 15ºC)...

10.1590/s0102-86502013000800003 article EN cc-by Acta Cirúrgica Brasileira 2013-07-27

Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the vasculature and occur at any age. There only few cases reported in international literature, most commonly associated surface epithelial-stromal germ cell tumours. Herein, authors report clinicopathologic features of an arising fibroma. A 65-year-old patient was admitted palpable mass hypogastrium. Grossly, removed ovary completely...

10.4061/2010/842592 article EN Pathology Research International 2010-10-31

Background: Gastric adenocarcinoma is more often found in men over 50 years the form of an antral lesion. The tumor has heterogeneous histopathologic features and a poor prognosis (median survival 15% five years). Aim: To estimate relationship between presence nodal metastasis other prognostic factors sporadic gastric adenocarcinoma. Method: Were evaluated 164 consecutive cases previously undergone gastrectomy (partial or total), without clinical evidence distant metastasis, determined...

10.1590/s0102-67202014000100005 article EN ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 2014-03-01

Liesegang rings are concentric noncellular lamellar structures, rarely seen in vivo, occurring as a consequence of the accumulation insoluble products colloidal matrix. These characteristic structures rare phenomenon usually found association with cystic or inflammatory lesions and may be mistaken for parasites. The authors examined from an kidney lesion identified previously tumoral on computerized tomography. On microscopic evaluation, can eggs larvae parasites, psammoma bodies...

10.4061/2010/602523 article EN Pathology Research International 2010-01-04

Malakoplakia is an unusual chronic inflammatory disease related to prior urinary tract infection. It characterized by the presence of macrophages with foamy cytoplasm exhibiting larger PAS positive inclusions that stain for calcium and iron. affects renal allograft associated severe morbidity. Herein, authors report a new case graft malakoplakia in 23-year-old female patient. The patient received living-related donor transplantation high immunological risk. Plasmapheresis intravenous...

10.5414/cn107506 article EN Clinical Nephrology 2012-11-29

IgA nephropathy (IgAN) is th e commonest primary glomerular disease worldwide. Studies on its prevalence in Brazil are however scarce. Databases and clinical records from 10 reference centres were retrospectively reviewed. Clinical laboratory features at the moment of biopsy retrieved (age, gender, presence hematuria, serum creatinine [mg/dL], proteinuria [g/24 h]). Renal findings classified according to Haas single grade classification scheme Oxford Classification IgAN. 600 cases IgAN...

10.1186/s40064-015-1323-x article EN SpringerPlus 2015-09-24

SUMMARY Refractory celiac disease is an uncommon condition which might be associated to poor prognosis. It often treated with immunosuppressive medications, results. divided in type 1 and 2, the latter carrying a high risk for lymphoma mortality. A case of 41 year old female patient refractory 2 reported. She was oral budesonide six months, achieving histological remission.

10.1590/1806-9282.67.02.20200618 article EN Revista da Associação Médica Brasileira 2021-02-01

A case of cryptococcosis due to capsule-deficient Cryptococcus is presented, in which culturing the clinical specimen and tests for capsular antigen cerebrospinal fluid serum were negative. The histopathological techniques evaluated hematoxylin-eosin, Grocott methenamine silver, Mayers mucicarmine Fontana-Masson. diagnosis was confirmed by means Fontana-Masson technique direct immunofluorescence. potential histochemical discussed.

10.1590/s0037-86822008000100015 article EN cc-by Revista da Sociedade Brasileira de Medicina Tropical 2008-02-01

O transplante renal alcançou expressivos e crescentes índices de sucesso desde sua implantação, constituindo atualmente uma terapia substitutiva larga escala. É cada vez mais freqüente o encontro biópsias enxerto na rotina dos laboratórios patologia, cujos achados são os variados. Este artigo resulta da experiência membros do Clube Rim (da Sociedade Brasileira Patologia) apresenta um panorama geral patologia renal, enfatizando a atual classificação Banff, com suas principais categorias...

10.1590/s1676-24442008000400010 article PT cc-by Jornal Brasileiro de Patologia e Medicina Laboratorial 2008-08-01

Myofibroblastoma (MFB) is a rare mesenchymal tumor arising in breast's soft tissue with great variety of microscopic features that can be mistaken wide biphasic lesions. The authors report case myofibroblastoma the breast mammary hamartoma (MH), present review clinicopathological these lesions, and make some diagnostic considerations. tumour consisted well-circumscribed nodule. MFB component comprised about fifty percent lesion was made up bipolar spindle cells arranged fascicular clusters...

10.4061/2010/726829 article EN Pathology Research International 2010-08-01

INTRODUÇÃO: O adenocarcinoma de próstata corresponde a uma das neoplasias malignas mais frequentes em homens, comprometendo principalmente da sexta oitava décadas. Algumas características histopatológicas do tumor, como grau diferenciação, invasão capsular e escore Gleason, podem ser correlacionadas com o prognóstico doença. OBJETIVOS: Estimar associação entre Gleason fatores prognósticos casos prostático. MATERIAL E MÉTODO: estudo avaliou 118 espécimes prostatectomia radical provenientes...

10.1590/s1676-24442010000100011 article PT cc-by Jornal Brasileiro de Patologia e Medicina Laboratorial 2010-02-01

Tufting enteropathy (TE), also known as intestinal epithelial dysplasia (IED), is a rare congenital related to an earlyonset of severe intractable diarrhea due specific abnormalities the epithelium and mutations EpCAM gene. TE characterized by clinical histological heterogeneity, such with low or without mononuclear cell infiltration lamina propria, basement membrane. can be associated malformations, other diseases, abnormal enterocytes development and/or differentiation. The authors report...

10.5935/1676-2444.20140021 article EN cc-by Jornal Brasileiro de Patologia e Medicina Laboratorial 2014-01-01

A retrospective analysis of sixteen patients with pulmonary nodules diagnosed as histoplasmoma by histopathologic evidence Histoplasma capsulatum var was done in an endemic area for histoplasmosis. Brazilian literature reviewed. All were white, nine men, mean age at diagnosis 50.8 years. Six (37.5%) had a relevant epidemiologic story. The 0.7-2.7 cm diameter, presenting granulomatous lesions caseous necrosis. Twelve (75%) solitary nodules. Histoplasmoma rule is nodule up to 3 asymptomatic...

10.1590/s0037-86822005000100003 article EN cc-by Revista da Sociedade Brasileira de Medicina Tropical 2005-02-01

Lipoprotein glomerulopathy (LPG) is a rare autosomal recessive associated with the deposition of lipoprotein thrombi in capillary lumina due to apoE gene mutations. Abnormal plasma profile and marked increase serum apoliprotein E (apoE) are characteristic clinical data. The compromised patients can present nephrotic syndrome, hematuria, progressive renal failure. Herein, authors first described case LPG Brazilian male patient, 11 years, who presented steroid-resistant syndrome. Renal...

10.5935/0101-2800.20140015 article EN cc-by Brazilian Journal of Nephrology 2014-01-01

Introduction: Primary ovarian neoplasms exhibit a wide range of histopathological aspects, and tumors with epithelial differentiation are the most frequent. Among malignant tumors, common histological type corresponds to serous adenocarcinoma, whose diagnosis is established in advanced stages disease approximately 75% patients. Tumor marker CA 125 represents glycoprotein synthesized mainly by neoplastic cells differentiation, its serum level seems be associated biological potential these...

10.1590/s1676-24442014000100003 article EN cc-by Jornal Brasileiro de Patologia e Medicina Laboratorial 2014-02-01

A 33-year old caucasian man was investigated for pain in the right flank, proteinuria, hemathuria and an elevated serum creatinine level. He also presented abnormal ultrasonography, which revealed asymmetric kidneys. Through renal biopsy, diagnosis of oligomeganephronia (OMN) confirmed. OMN is a very rare form hypoplasia, late-onset adulthood even rarer. In pediatric population, leads to end-stage-renal-failure(ESRF) few years. This sixth case related literature who have not yet developed ESRF.

10.5935/0101-2800.20120030 article EN cc-by Brazilian Journal of Nephrology 2012-01-01

Introduction: Pre-implantation kidney biopsy is a decision-making tool when considering the use of grafts from deceased donors with expanded criteria, implanting one or two kidneys and comparing this to post-transplantation biopsies. The role histopathological alterations in compartments as prognostic factor graft survival function has had conflicting results. Objective: This study evaluated prevalence chronic pre-implant biopsies association findings year post-transplant. Methods: 110 were...

10.5935/0101-2800.20140029 article EN cc-by Brazilian Journal of Nephrology 2014-01-01

Russell body gastritis (RBG), which can be associated with Helicobacter pylori (HP) infection, is a recently acknowledged lesion characterized by the presence of eosinophilic intracytoplasmic inclusions in plasmacytes. Herein authors discuss morphological aspects case RBG male patient clinical complaint epigastric pain. Upper endoscopy revealed areas erythema/edema antrum. As far as microscopy concerned, mononuclear inflammatory infiltrate was identified on lamina propria, plasma cells...

10.1590/s1676-24442012000100008 article EN cc-by Jornal Brasileiro de Patologia e Medicina Laboratorial 2012-02-01
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