A5103009311- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nerve injury and regeneration
- Ion Transport and Channel Regulation
- Botulinum Toxin and Related Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Mitochondrial Function and Pathology
- Medicinal Plants and Neuroprotection
- Autism Spectrum Disorder Research
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Academic Research in Diverse Fields
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Business and Management Studies
University of Brescia
2012-2020
Centro San Giovanni di Dio Fatebenefratelli
2017
Universidade Federal de Santa Maria
2013-2016
University of Padua
2009
The main neuropathological features of Parkinson's disease are dopaminergic nigrostriatal neuron degeneration, and intraneuronal intraneuritic proteinaceous inclusions named Lewy bodies neurites, respectively, which mainly contain α-synuclein (α-syn, also known as SNCA). neuronal phosphoprotein synapsin III (also SYN3), is a pivotal regulator dopamine synaptic function. Here, we show that α-syn interacts with modulates III. absence causes selective increase redistribution III, changes the...
Loss of dopaminergic nigrostriatal neurons and fibrillary α-synuclein (α-syn) aggregation in Lewy bodies (LB) characterize Parkinson's disease (PD). We recently found that Synapsin III (Syn III), a phosphoprotein regulating dopamine (DA) release with α-syn, is another key component LB fibrils the brain PD patients acts as crucial mediator α-syn toxicity. Methylphenidate (MPH), monoamine reuptake inhibitor (MRI) efficiently counteracting freezing gait advanced patients, can bind controls...
Ciliary neurotrophic factor (CNTF) regulates the differentiation and survival of a wide spectrum developing adult neurons, including motor neuron loss after injury. We recently described cell-penetrant recombinant human CNTF (rhCNTF) molecule, formed by fusion with immunodeficiency virus-1 transactivator transcription (TAT) protein transduction domain (TAT-CNTF) that, upon subcutaneous administration, retains full activity without cytokine-like side-effects. Although receptor is present in...
Statins are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase, rate-limiting step in cholesterol biosynthesis. effectively prevent and reduce risk coronary artery disease through lowering serum cholesterol, also exert anti-thrombotic, anti-inflammatory antioxidant effects independently changes levels. On other hand, clinical experimental evidence suggests that abrupt cessation statin treatment (i.e. withdrawal) is associated with a deleterious rebound phenomenon. In...
Loss-of-function mutations in the progranulin (PGRN) gene are a common cause of familial frontotemporal lobar degeneration (FTLD). This age-related neurodegenerative disorder, characterized by brain atrophy frontal and temporal lobes such typical symptoms as cognitive memory impairment, profound behavioral abnormalities, personality changes is thought to be related connectome dysfunctions. Recently, PGRN reduction has been found induce phenotype reminiscent FTLD mice affecting neuron spine...