A5086530354- Acute Lymphoblastic Leukemia research
- Ocular Oncology and Treatments
- Renal and related cancers
- Brain Metastases and Treatment
- Renal cell carcinoma treatment
- Histiocytic Disorders and Treatments
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Nonmelanoma Skin Cancer Studies
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- interferon and immune responses
- Parvovirus B19 Infection Studies
- Phagocytosis and Immune Regulation
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Bone and Joint Diseases
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- Cancer-related Molecular Pathways
- Viral-associated cancers and disorders
- Vascular Malformations and Hemangiomas
- Childhood Cancer Survivors' Quality of Life
- DNA Repair Mechanisms
- Macrophage Migration Inhibitory Factor
Charles University
2010-2024
University Hospital in Motol
2010-2023
Vilnius University
2021
University College London
2021
Masaryk University
2021
N.N. Alexandrov National Cancer Centre
2021
Children's Clinical University Hospital
2021
Moorfields Eye Hospital NHS Foundation Trust
2021
East Tallinn Central Hospital
2021
University Hospital Brno
2021
PURPOSE Off-label use of vemurafenib (VMF) to treat BRAF V600E mutation–positive, refractory, childhood Langerhans cell histiocytosis (LCH) was evaluated. PATIENTS AND METHODS Fifty-four patients from 12 countries took VMF 20 mg/kg/d. They were classified according risk organ involvement: liver, spleen, and/or blood cytopenia. The main evaluation criteria adverse events (Common Terminology Criteria for Adverse Events [version 4.3]) and therapeutic responses Disease Activity Score. RESULTS...
Abstract Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder caused by somatic genetic alterations in hematopoietic precursor cells differentiating into CD1a+/CD207+ histiocytes. LCH clinical manifestation highly heterogeneous. BRAF and MAP2K1 mutations account for ∼80% of driver cells. However, their associations remain incompletely understood. Here, we present an international clinicogenomic study childhood LCH, investigating 377 patients genotyped at least BRAFV600E. MAPK...
Abstract Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation damaging immune cells into surrounding tissues are poorly understood. Here we identified three unrelated boys with perinatal-onset neutrophilic cutaneous small vessel vasculitis and systemic inflammation. Two patients developed liver fibrosis in their first year life. Next-generation sequencing two de novo truncating variants the Src-family tyrosine...
CD148 is a receptor-like protein-tyrosine phosphatase known to inhibit transduction of mitogenic signals in non-hematopoietic cells. Similarly, the hematopoietic lineage, inhibited signal downstream T cell receptor. However, it also augmented immunoreceptor signaling B cells and macrophages via dephosphorylating C-terminal tyrosine Src family kinases (SFK). Accordingly, endogenous compensated for loss main SFK activator CD45 murine but not Hypothetical explanations difference between other...
Abstract Poly(2‐hydroxyethyl methacrylate) (pHEMA) hydrogels are well known in ophthalmological applications and recently investigated as drug delivery systems. The study represents a theoretical approach where the sorption/desorption experiments spectroscopic is used to describe influence of pHEMA network structure on sorption capacity mechanism release topotecan (TPT) vincristine (VCR). synthesized by free‐radical crosslinking polymerization HEMA monomer with ethylene glycol dimethacrylate...
Abstract Introduction Advanced intraocular retinoblastoma can be cured by enucleation, but spread of cells beyond the natural limits eye is related to a high mortality. Adjuvant therapy after enucleation has been shown prevent metastasis in children with risk factors for extraocular retinoblastoma. However, histological criteria and adjuvant treatment regimens vary there no unifying consensus on optimal choice treatment. Method Data guidelines European referral centres were collected an...
Abstract Background Recently, several studies have demonstrated a negative prognostic impact of Ikaros ( IKZF1 ) gene alterations in acute lymphoblastic leukemia (ALL). However, controversies still exist regarding the current treatment protocols. Procedure We simultaneously detected deletions by multiplex ligation‐dependent probe amplification and expression isoforms 206 children with BCR / ABL ‐negative ALL treated IC‐BFM 2002 protocol, which risk stratification was not based on minimal...
Transscleral diffusion delivery of chemotherapy is a promising way to reach the vitreal seeds retinoblastoma, most common intraocular malignancy in childhood. In this vivo study, topotecan via lens-shaped, bi-layered hydrogel implants was combined with transconjunctival cryotherapy assess whether leads higher concentrations vitreous. The study included 18 New Zealand albino rabbits; nine rabbits received topotecan-loaded implant episclerally and another superotemporally 2 weeks before...
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Cancer treatment can cause various long-term side effects, including those that impact ultrasound findings. During follow-up of childhood cancer survivors (CCSs), we often detected sporadic renal angiomyolipomas without histological confirmation (SAMLs), which is why initiated this study. We compared the occurrence SAML in CCSs to previously reported data from a non-cancer population and correlated with treatment-related factors.The cohort included 1098 (median age at diagnosis (dg) 4.3...
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Klinika dětské hematologie a onkologie, Fakultní nemocnice