A5036231642- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Garlic and Onion Studies
- Porphyrin and Phthalocyanine Chemistry
- Advanced biosensing and bioanalysis techniques
- Arsenic contamination and mitigation
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Nephrotoxicity and Medicinal Plants
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Acute Ischemic Stroke Management
- Cancer Research and Treatments
- Nitrogen and Sulfur Effects on Brassica
- Electrospun Nanofibers in Biomedical Applications
- Virus-based gene therapy research
- Surgical Simulation and Training
- Hydrogels: synthesis, properties, applications
- Radiation Therapy and Dosimetry
- Innovations in Medical Education
- Bacteriophages and microbial interactions
- Retinal and Macular Surgery
- Organ and Tissue Transplantation Research
- Neuroendocrine Tumor Research Advances
- Corneal Surgery and Treatments
Philipps University of Marburg
2013-2025
Universitätsklinikum Gießen und Marburg
2024
Max Planck Institute for Biophysical Chemistry
2008
Photodynamic therapy (PDT) is an established noninvasive tumor treatment. The hydrophobic natural occurring pigment hypericin shows a lot of attractive properties for the application in PDT. Hence, administration to biological systems or patients requires formulation drug carriers enabling sufficient bioavailability. Therefore, free was encapsulated by thin film hydration method hypericin-hydroxypropyl-β-cyclodextrin inclusion complex (Hyp-HPβCD) incorporated dehydration-rehydration vesicle...
In the presence of escalating global concerns regarding physician burnout, this study aims to analyze prevalence and associated factors burnout among radiologists in Germany.
Photodynamic therapy (PDT) is a minimally invasive tumor targeting strategy, in which tissues can be selectively destroyed. Upon excitation with light of specific wavelength, photosensitizer produce reactive oxygen species (ROS) the presence molecular oxygen, thereby exhibiting cytotoxic effect toward surrounding tissues, giving total control on onset therapy. In this research work, curcumin as natural has been investigated against cancer cells. To enhance solubility curcumin,...
Background: Hypoxic-ischemic brain injury (HIBI) is a feared complication post-cardiac arrest (CA). The timing of imaging remains topic ongoing debate. Early computed tomography (CT) scans can reveal acute intracranial pathologies but may have limited predictive value due to delayed manifestation HIBI-related changes. Radiomics analyses present promising approach identifying subtle markers, potentially aiding early HIBI detection. Methods: This study retrospectively assessed post-CA patients...
Purpose: Lipoparticles are the core-shell type lipid-polymer hybrid systems comprising polymeric nanoparticle core enveloped by single or multiple pegylated lipid layers (shell), thereby melding biomimetic properties of long-circulating vesicles as well mechanical advantages nanoparticles. The present study was aimed at development such an integrated system, combining photodynamic and chemotherapeutic approaches for treatment multidrug-resistant cancers. Methods: For this rationale, two...
Due to its highly lipophilic nature, poor solubility in aqueous media, and bioavailability, the naturally occurring photosensitizer hypericin has a limited therapeutic value. Liposomal encapsulation is promising solution overcome these limitations. Use of liposomes as delivery vehicles for antimicrobial photodynamic therapy (aPDT) quite new. The aim this work therefore, prepare various loaded liposomal formulations viz. DOPE/CHEMS/DPPC, DSPC/DPPC/DSPE‐PEG, DPPC/DOTAP. are physicochemically...
The chorioallantoic membrane (CAM) of fertilized hen's eggs represents a unique and alternative model for cancer research. CAM provides an optimal platform xenografting cell lines studying essential key factors. Tumor size growth as well angiogenesis can be investigated to evaluate the response therapies strategies against cancer. Preclinical imaging represented by magnetic resonance positron emission tomography/computed tomography generate detailed anatomical functional information reveal...
Biomaterials, which release active compounds after implantation, are an essential tool for targeted regenerative medicine. In this study, thin multilayer films loaded with lipid/DNA complexes (lipoplexes) were designed as surface coatings in situ transfection applicable tissue engineering and The film production embedding of lipoplexes based on the layer-by-layer (LbL) deposition technique. Hyaluronic acid (HA) chitosan (CHI) used polyelectrolyte components. embedded plasmid DNA was...
Lipid vectors are commonly used to facilitate the transfer of nucleic acids into mammalian cells. In this study, two fractions tetraether lipids from archaea Sulfolobus acidocaldarius were extracted and purified using different methods. The lipid polar fraction E (PLFE) hydrolysed glycerol-dialkyl-nonitol (hGDNT) differ in their structures, charge, size, miscibility conventional lipids. Liposomes prepared by mixing with cholesterol (CH) 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)...
The alarming growth of multi-drug resistant bacteria has led to a quest for alternative antibacterial therapeutics. One strategy circumvent the already existing resistance is use photodynamic therapy. Antimicrobial therapy (aPDT) involves non-toxic photosensitizers in combination with light and situ oxygen generate toxic radical species within microbial environment which circumvents building mechanism bacteria. Hydrogels are used ubiquitously biological pharmaceutical fields, e.g., wound...
Photodynamic therapy (PDT) that involves ergonomically delivered light in the presence of archetypical photosensitizer such as Protoporphyrin IX (PpIX) is a time-honored missile strategy cancer therapeutics. Yet, premature release PpIX one most abundant dilemma encounters therapeutic outcomes PDT due to associated toxicity and redistribution serum proteins. In this study, ultrastable tetraether lipids (TELs) based liposomes were developed. molecules identified reside physically monolayer;...
Three new sulfur-containing compounds were identified in Allium L. species belonging to the subgenus Melanocrommyum as first examples of pyrrole derivatives nature. Some these are traditionally used Southwest and Central Asia vegetables herbal drugs. A hypothetical biogenetic scheme is proposed which L-(+)- S-(3-pyrrolyl)cysteine sulfoxide enzymically degraded. The resulting 2-lactyl-3'-pyrrolyl condensed readily red pigment 3,3'-dithio-2,2'-dipyrrole. All chemically unstable, rendering...