A5040351790- Forensic Toxicology and Drug Analysis
- Poisoning and overdose treatments
- Cannabis and Cannabinoid Research
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Hormonal and reproductive studies
- Opioid Use Disorder Treatment
- Treatment of Major Depression
- Botulinum Toxin and Related Neurological Disorders
- Tryptophan and brain disorders
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Dialysis and Renal Disease Management
- Analytical Methods in Pharmaceuticals
- Restraint-Related Deaths
- Epilepsy research and treatment
- Anesthesia and Sedative Agents
- Bipolar Disorder and Treatment
- Plant-based Medicinal Research
- HIV/AIDS drug development and treatment
- Pesticide Exposure and Toxicity
Inserm
2016-2025
Hôpital Raymond-Poincaré
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris-Saclay
2017-2025
Centre de recherche en Epidémiologie et Santé des Populations
2023-2025
Université de Versailles Saint-Quentin-en-Yvelines
2015-2024
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2019-2023
Infection et inflammation
2014-2023
Université de Picardie Jules Verne
2023
SKF (France)
2023
Diagnosis of adrenal insufficiency in critically ill patients has relied on random or cosyntropin-stimulated cortisol levels, and not been corroborated by a more accurate diagnostic standard.We used the overnight metyrapone stimulation test to investigate value standard cosyntropin test, prevalence sepsis-associated insufficiency.This was an inception cohort study.In two consecutive septic cohorts (n = 61 n 40), 44 without sepsis 32 healthy volunteers, we measured (1) serum before after...
PURPOSE Off-label use of vemurafenib (VMF) to treat BRAF V600E mutation–positive, refractory, childhood Langerhans cell histiocytosis (LCH) was evaluated. PATIENTS AND METHODS Fifty-four patients from 12 countries took VMF 20 mg/kg/d. They were classified according risk organ involvement: liver, spleen, and/or blood cytopenia. The main evaluation criteria adverse events (Common Terminology Criteria for Adverse Events [version 4.3]) and therapeutic responses Disease Activity Score. RESULTS...
A new rapid and sensitive high-performance liquid chromatography method has been developed for the screening determination in human plasma of 11 most commonly prescribed nontricyclic antidepressants two metabolites: fluoxetine, norfluoxetine, sertraline, paroxetine, citalopram, fluvoxamine, moclobemide, mirtazapine, milnacipram, toloxatone, venlafaxine, desmethyl viloxazine. It involves liquid-liquid extraction procedures followed by coupled to photodiode-array UV detection with three fixed...
Background The analgesic effect of perioperative low doses intravenous lidocaine has been demonstrated after abdominal surgery. This study aimed to evaluate whether a continuous low-dose infusion reduced postoperative pain and modified nociceptive threshold total hip arthroplasty. Methods Sixty patients participated in this randomized double-blinded study. Patients received 1% (lidocaine group) with 1.5 mg/kg bolus 10 min followed by mg . kg h or saline (control group). These regimens were...
Background Droperidol and ondansetron have previously been found to prolong the QT interval in treatment of postoperative nausea vomiting. However, this adverse effect has never confirmed compared with both drugs under controlled conditions. The objective was study effects droperidol alone or combination on duration healthy subjects. Methods Sixteen volunteers, eight males females, were enrolled prospective, double-blind, randomized, placebo-controlled study. Subjects received 1 mg...
Pediatric cardiac surgery patients are at high risk for bleeding, and the antifibrinolytic drug tranexamic acid (TA) is often used to reduce blood loss. However, dosing schemes remain empirical as a consequence of absence pharmacokinetic study in this population. The authors' objectives were thus investigate population pharmacokinetics TA pediatric during cardiopulmonary bypass (CPB).Twenty-one randomized receive either continuously (10 mg/kg followed by an infusion 1 mg · kg h(-1)...
Abstract Recently, the emergence of new psychoactive substances (NPS) has led to their wide use among clubbers and men who have sex with (MSM) for stimulant effects. However, in drug‐facilitated sexual assault (DFSA) rarely been described. Herein we report a case 44‐year‐old man was assaulted after party. Due late reporting offense, only hair (black) sampled 15 days later segmental analysis achieved look most DFSA agents NPS. Twenty mg each segment (A: 0–1 cm, B: 1–3 C: 3–5 cm) were...
Abstract Untargeted liquid chromatography–high resolution mass spectrometry (LC–HRMS) techniques have become indispensable tools for systematic toxicological analysis. They allow the research of an almost unlimited number drugs within a single analytical cycle, but shared spectra libraries are still missing to identify newly marketed compounds, along with defined procedures. This article describes optimization, validation, and application untargeted screening method devoted hair analysis...
Abstract Objectives A method based on liquid chromatography coupled to triple quadrupole mass spectrometry detection using 50 µL of plasma was developed and fully validated for quantification remdesivir its active metabolites GS-441524. Methods simple protein precipitation carried out 75 methanol containing the internal standard (IS) remdesivir- 13 C 6 5 ZnSO4 1 M. After separation Kinetex ® 2.6 µm Polar C18 100A LC column (100 × 2.1 mm i.d.), both compounds were detected by a spectrometer...
To determine if amiodarone, highly lipophilic, accumulates in excess with respect to dose fat tissue during long-term administration, and study plasma concentrations are correlated adverse effects.Trough of amiodarone N-desethyl-amiodarone were measured simultaneously tissue, 30 consecutive patients treated for 3 months 12 years. Subcutaneous adipose was obtained by needle aspiration from lumbar abdominal areas. Concentrations liquid chromatography-tandem mass spectrometry.Plasma levels...
Abstract BACKGROUND The pharmacokinetic–pharmacodynamic relationship between whole blood δ-9-tetrahydrocannabinol (THC) and driving risk is poorly understood. METHODS Fifteen chronic cannabis consumers (1–2 joints/day; CC) 15 occasional joints/week; OC) of 18 to 34 years age were included. A pharmacokinetic study was conducted with 12 samplings over a 24-h period before after controlled random inhalation placebo or 10 mg 30 THC. THC metabolites quantified using LC-MS/MS. Effects on reaction...
Importance The DRAMES (Décès en Relation avec l’Abus de Médicaments Et Substances) register is a database of drug-related deaths with the aim identifying psychoactive substances associated and estimating trends in these deaths. Our novel approach based on collection data all for which toxicology experts have performed analyses. Objective To describe France report over an 11-year period. Design, Setting, Participants This case series used national to assess 4460 that occurred from 2011 2021...