A5017533597- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Neurological Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Ocular Oncology and Treatments
- Ophthalmology and Visual Impairment Studies
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Cerebral Venous Sinus Thrombosis
- Ocular and Laser Science Research
- Visual perception and processing mechanisms
- Ocular Infections and Treatments
- Photoreceptor and optogenetics research
- Systemic Lupus Erythematosus Research
- Healthcare Systems and Public Health
- Ocular Disorders and Treatments
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
- Cerebrovascular and Carotid Artery Diseases
Helmholtz Moscow Research Institute of Eye Diseases
2015-2024
Ministry of Health of the Russian Federation
2006-2024
Moscow State University of Medicine and Dentistry
2020-2024
Vilnius University
2021
University College London
2021
Masaryk University
2021
N.N. Alexandrov National Cancer Centre
2021
Children's Clinical University Hospital
2021
Moorfields Eye Hospital NHS Foundation Trust
2021
East Tallinn Central Hospital
2021
Glaucoma is a progressive optic neuropathy associated with damage to retinal ganglion cells (RGCs) and disrupted circadian rhythms. Melatonin promising substance ameliorate glaucoma-associated compromised rhythms, sleep, mood, function. However, studies estimating melatonin effects in glaucoma are currently lacking. Therefore, In this study, we investigated the effect of long-term (daily at 10:30 pm for 90 days) oral administration on systemic (Tb) local organ vision (IOP) pattern...
In Russia, a complex approach to diabetes mellitus and diabetic retinopathy (DR) treatment is adopted, yet certain issues remain in the system of medical care for DR patients. The statistical data are important assess availability quality each region Russian Federation, plan resource distribution, determine volume medicinal technical support. article presents an analysis territorial differences prevalence dispensary follow-up order eliminate defects organization such patients, improvement...
The Purpose of this work was to determine microvascular changes in the macular zone with diabetes mellitus (DM) and different stages diabetic retinopathy (DR) using optical coherence tomography angiography (OCT-A). Materials methods. 60 patients were inspected (109 eyes) between ages 58.20 ± 3.27 DM (patients without clinical DR DR). control group consisted 75 healthy subjects (150 compared by gender age group. OCT-A performed help instrument RTVue XR Avanti (Optovue Inc, USA) Angio Retina...
Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed patients with stable or advanced primary open-angle glaucoma (S-POAG/A-POAG) and referenced to the phase “marker” circadian temperature each patient. Body IOP measured over a 72-h span 115 participants (65 S-POAG 50 A-POAG). Retinal Ganglion Cell (RGC) damage was by high-definition optical coherence tomography. The A-POAG peaked during night, opposite daytime position (p < 0.0001). correlated RGC loss internal shift...
To describe the feasibility of same-day, consecutive use a single donor cornea in 5 patients with corneal pathology, who required anterior lamellar and endothelial keratoplasties.Descemet membrane (DM) endothelium was completely stripped from corneoscleral button punched out side circular, standard punch. Using custom-made punch for linear cutting DM, we obtained 4 quarter-grafts (Q-graft). The denuded punched-out stroma transplanted 1 patient keratoconus, using big-bubble deep keratoplasty...
The novel coronavirus infection (COVID-19) caused by SARS-CоV-2 virus, may lead to ocular diseases besides affecting the respiratory system. Cororonavirus be transmitted not only through system but also conjunctiva. review article summarizes data on origin and variants of coronaviruses that infect humans, as well structures. Literature prospects molecular diagnostics disease, type detection methods, clinical sample types duration disease before it is diagnosed are discussed. relationship...
Small choroidal melanoma is a malignant tumor that prone to early metastasis, its amelanotic form often similar circumscribed hemangioma. The main attribute for identification vascularization, which the target of various examination methods. Optical coherence tomography angiography (OCTA) has not been previously used in complex diagnostics and hemangioma detection vessels nature their branching, as well vessel caliber comparison. Purpose examine vascularization uveal by optical...
Coronaviruses (CoV) are a large group of RNA viruses that pathogenic to animals and humans. Until the end 20th century, human CoV were known as pathogens seasonal mild respiratory diseases. In last 20 years new CoVs caused three outbreaks severe acute diseases with predominant lesion lower tract: SARS-CoV — causative agent syndrome (SARS) in 2002–2003; MERS-CoV induced Middle East (MERS) 2012 SARS-CoV-2 coronavirus disease-19 (COVID-19), pandemic which began China late 2019 is ongoing. The...
Lipid metabolism is intimately linked to circadian mechanisms and light signaling. Deteriorated photic transduction because of retinal ganglion cell (RGC) loss occurring with glaucoma progression reduces perceived amplitude, causing disruption. To investigate associations RGCs, total cholesterol (TC), its low-density (LDL-C) high-density (HDL-C) fractions, triglycerides (TG) were measured, under a controlled meal regimen, during daytime hours in 114 patients diagnosed primary open-angle...
The high prevalence of primary open-angle glaucoma, its leading role in the structure visual disability, and insufficient effectiveness treatment, prevention rehabilitation measures require new approaches to providing quality care patients with glaucoma. It is important analyze epidemiological situation, human technological resources various regions Russian Federation. paper evaluates compliance specialized medical glaucoma approved clinical guidelines CR 96 “Primary glaucoma” Federation...
Despite a comprehensive approach to the problem of diabetes mellitus (DM) and diabetic retinopathy (DR) in Russian Federation, number problems persist medical care for patients with DM. The analysis statistical data makes it possible assess availability quality each region Federation plan distribution resources - medicinal technical support. This paper presents geographical DR general incidence, visibility impairment due DR, proportion timely detected course primary preventive healthcare,...
Myopic refraction is the most common ocular pathology, currently affecting about 1.5 billion people worldwide. Recent decades have seen a trend towards significant increase in myopia prevalence, which likely to continue near future. Therefore, we observe some kind of an epidemic myopia. The greatest concern caused by cases uncorrectable visual impairment associated with myopia, make pathological (degenerative) one leading causes low vision and blindness many countries. At same time, there...
Purpose : сomparative clinical and diagnostic efficiency of the quality life (QОL) according to PHEC-22 Catquest-9SF questionnaires after bilateral cataract phacoemulsification monofocal IOL implantation. Patients Methods . We observed 148 patients with binocular (mean age 58.6 ± 1.8 years). All underwent standard implantation a IOL. were examined before (one month surgery on second eye) surgery. The results survey evaluated by general indicator testing (GIT) as sum points for all questions...
The system of blindness prevention and visual impairment in children with retinopathy prematurity is a multidisciplinary medical problem, includes the preterm birth, correction terms caring for premature babies, early detection, monitoring, treatment prematurity, as well organization long clinical supervision. Patients need comprehensive approach to order ensure high functional outcomes improve their quality life.
Intravitreal drug administration is a procedure that has become widespread in modern ophthalmology. However, there no global consensus on certain aspects of this manipulation, and practitioners feel the need for guidelines. In Russian Federation, until now, such document was not available. The expert council diseases retina optic nerve All-Russian public organization «Association Ophthalmologists», with participation invited specialists, studied analyzed existing foreign guidelines...
Purpose : to develop easy-to make and reproducible models of retinal pigment epithelium atrophy (RPE) degeneration using two types solution (0.9 % sodium chloride bevacizumab) evaluate these clinical instrumental pathomorphological studies. Material methods . To create the models, we used 60 New Zealand albino rabbits divided into 2 groups 30 animals each (30 eyes). In group 1, 0.01 ml 0.9 was delivered subretinal space at a distance 1–1.5 mm downwards from optic disc forming bladder, whilst...
to comparatively investigate accommodation, pseudoaccommodation, and higher-order aberrations in children young adults with myopia hyperopia.A total of 39 myopic (the mean error (-)5.2±1.5 diopters) 53 hyperopic (+)3.1±1.15 eyes 46 patients aged 5-20 years (11.6±0.6 on average) were enrolled. Examination included evaluation the objective accommodative response, relative accommodation reserves, pseudoaccommodation volume (calculated as difference between (+)3.0-diopter lens that is necessary...
Today, diabetic macular edema (DME) is still one of the main causes vision loss in patients with diabetes.To identify changes ocular blood flow and microvascular network zone DME after antiangiogenic therapy.In course study, 25 (50 eyes) monolateral clinically significant aged 67.5±3.85 years were examined. Control group consisted 75 healthy subjects (150 eyes). All underwent ultrasound examination eyes orbits (in Color Doppler Imaging (CDI) Pulse-Doppler modes) OCT-angiography (OCT-A)...