A5102790452- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Climate Change and Health Impacts
- Healthcare Systems and Public Health
- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- Human Health and Disease
- Glaucoma and retinal disorders
- Sleep and Wakefulness Research
- Dietary Effects on Health
- Obesity, Physical Activity, Diet
- Blood Pressure and Hypertension Studies
- Retinal Development and Disorders
- Eating Disorders and Behaviors
- Cardiovascular Disease and Adiposity
- Behavioral Health and Interventions
- Psychological and Temporal Perspectives Research
- Sleep and Work-Related Fatigue
- Neurological Disorders and Treatments
- Thermoregulation and physiological responses
- Electromagnetic Fields and Biological Effects
- Psychological Well-being and Life Satisfaction
- Diet and metabolism studies
- Impact of Light on Environment and Health
- Physical Education and Training Studies
Tyumen State Medical University
2016-2025
Tomsk National Research Medical Center
2018-2025
Russian Academy of Sciences
2022-2025
Masaryk University
2024
Gazprom (Russia)
2016
Institute of Cardiology
2016
University of Minnesota System
2000-2002
SIS Medical (Switzerland)
1994
Abstract In humans, sleep regulation is tightly linked to social times that assign local time events, such as school, work, or meals. The impact of these times, collectively—social pressure, on has been studied epidemiologically via quantification the discrepancy between workdays and those work-free days. This known jetlag (SJL). COVID-19-mandated restrictions (SR) constituted a global intervention by affecting worldwide. We launched Global Chrono Corona Survey (GCCS) queried sleep–wake...
Seven-day actigraphy was performed within 1 month in 122 community-dwelling adults (mean age 24.40 y, 31 (25.4%) men) the same city of Tyumen, Russia. Groups with different COVID-19 status (present, COVID-19(+),
Glaucoma is a progressive optic neuropathy associated with damage to retinal ganglion cells (RGCs) and disrupted circadian rhythms. Melatonin promising substance ameliorate glaucoma-associated compromised rhythms, sleep, mood, function. However, studies estimating melatonin effects in glaucoma are currently lacking. Therefore, In this study, we investigated the effect of long-term (daily at 10:30 pm for 90 days) oral administration on systemic (Tb) local organ vision (IOP) pattern...
Summary Light is an important regulator of daily human physiology in providing time‐of‐day information for the circadian clock to stay synchronised with 24‐hr day. The coronavirus disease 2019 (COVID‐19) pandemic led social restrictions many countries prevent virus spreading, that dramatically altered routines and limited outdoor daylight exposure. We previously reported sleep duration increased, jetlag decreased, mid‐sleep times delayed during (Global Chrono Corona Survey, N = 7,517). In...
Circadian rhythms are an inherent property of all living systems and essential part the external internal temporal order. They enable organisms to be synchronized with their periodic environment guarantee optimal functioning organisms. Any disturbances, so-called circadian disruptions, may have adverse consequences for health, physical mental performance, wellbeing. The environmental light–dark cycle is main zeitgeber rhythms. Moreover, regular activity most useful. Not only does it general...
This study explores the relationship between light features of Arctic spring equinox and circadian rhythms, sleep metabolic health. Residents (N = 62) provided week-long actigraphy measures, including exposure, which were related to body mass index (BMI), leptin cortisol. Lower wrist temperature (wT) higher evening blue exposure (BLE), expressed as a novel index, nocturnal excess (NEIbl), most sensitive measures associated with BMI. A BMI was linked BLE within distinct time windows. These...
Increased blood pressure and reduced robustness of circadian rhythms are frequently reported in elderly subjects. The present study was aimed to investigate whether such changes can be reversed by daily melatonin ingestion. 97 normotensive hypertensive volunteers both genders 63 91 years old participated. They lived the Tyumen Elderly Veteran House on a self-chosen sleep-wake regimen suit their personal convenience. experiment lasted for three weeks. After one control week, part group (n=63)...
The aim of the present study was to investigate impact endogenous and exogenous factors for expression daily rhythms body temperature (BT), blood pressure (BP) heart rate (HR). One hundred seventy-three young adults (YA), 17–24 years old (y.o.), both genders were studied under a modified constant-routine (CR) protocol 26 h. Participants assigned randomly groups with different lighting regimens: CR-LD, n = 77, lights (>400 l×) on from 09:00 17:00 h off (<10 next morning; CR-LL, 81, during...
A weekly actigraphy was conducted within a single month in 122 young adults, who were categorized into two groups: COVID(-): individuals without SARS-CoV-2 infection, n = 43; COVID(+), 79: with confirmed infection. Physical activity, wrist temperature, sleep parameters, and light exposure compared. Higher daytime ambient (LE), blue (BLE) ultraviolet B (UVBE) COVID(-) group. In multivariate model, incorporating BLE amplitude, M10 of physical age, sex, amplitude remained the only significant...
Light environment in the Arctic differs widely with seasons. Studies of relationships between objectively measured circadian phase and amplitude light exposure melatonin community-dwelling residents are lacking. This investigation combines cross-sectional (n = 24-62) longitudinal 13-27) data from week-long actigraphy (with sensor), 24-h salivary profiles, proxies metabolic health. Data were collected within same week bracketing spring equinox (SE), winter/summer solstices (WS/SS). Drastic...
Advanced primary open-angle glaucoma (POAG) is characterized by progressive retinal ganglion cell complex (RGCC) damage that may cause subsequent disruption of the circadian rhythms. Therefore, we evaluated body temperature (BT) rhythm and sleep characteristics 115 individuals (38 men 77 women) diagnosed with POAG. GLV (global loss volume; %), a measure RGCC damage, was estimated high-definition optical coherence tomography, RGC functional ability assessed pattern electroretinogram amplitude...
Background. The COVID-19 lockdown has had a significant impact on mental health. Patients with eating disorders (ED) have been particularly vulnerable. Aims. (1) To explore changes in eating-related symptoms and general psychopathology during patients an ED from various European Asian countries; (2) to assess differences related diagnostic subtypes, age, geography. Methods. sample comprised 829 participants, diagnosed according DSM-5 criteria specialized units Europe Asia. Participants were...
The present study is part of a more extensive investigation dedicated to the and treatment age‐dependent changes/disturbances in circadian system humans. It was performed Tyumen Elderly Veteran House included 97 subjects both genders, ranging from 63 91 yrs age. They lived self‐chosen sleep‐wake regimen suit their personal convenience. experiment lasted 3 wks. After 1 control week, group (n=63) received 1.5 mg melatonin (Melaxen™) daily at 22:30 h for 2 other 34 were given placebo. Axillary...
We report a progressive disruption of 24-h rhythms in fasting blood glucose (FBG), body temperature (BT) and heart rate (HR) associated with metabolic dysfunction the development prediabetes (PD) type 2 diabetes mellitus (T2DM) overweight middle-aged (40–69 years old) humans. Increasing BT HR mean values declining amplitudes accompany adverse changes state. Increased nocturnal phase delay rhythm, deviant profile advance FBG are early signs PD In T2DM, rhythm is no longer detectable, greatly...
Background: Blood pressure (BP) variability is involved in the appraisal of threat and safety, can serve as a potential marker psychological resilience against stress. The relationship between biological rhythms BP was cross-sectionally assessed by 7-day/24-hour chronobiologic screening rural Japanese community (Tosa), with focus on 12-hour component "circadian-circasemidian coupling" systolic (S) BP. Subjects Methods: Tosa residents (N = 239, 147 women, 23– 74 years), free anti-hypertensive...
Nuclear receptor subfamily 1 group D member (NR1D1 or REV-ERBα) is a crucial element of the circadian clock&#039;s transcriptional and translational feedback loop. Understanding its expression in humans critical for elucidating role rhythms metabolic processes, finding potential links to various pathologies. In longitudinal survey we examined REV-ERBα at 08:00 using real-time polymerase chain reaction (qRT-PCR) blood mononuclear cells from Arctic native non-native residents during...
Nuclear receptor subfamily 1 group D member (NR1D1 or REV-ERBα) is a crucial element of the circadian clock’s transcriptional and translational feedback loop. Understanding its expression in humans critical for elucidating role rhythms metabolic processes, finding potential links to various pathologies. In longitudinal survey, we examined REV-ERBα at 08:00 using real-time polymerase chain reaction (qRT-PCR) blood mononuclear cells from Arctic native non-native residents during equinoxes...
Установлено, что при уменьшении концентрации натрия в слюне происходит усиление минералокортикоидной активности надпочечников (повышение крови альдостерона и адренокортикотропного гормона). Целью исследования явилось изучение изменения суточного ритма онтогенезе у людей на примере слюны, отражающего состояние симпато-адреналовой системы, во все сезоны года. Материалы методы. У 58 человек исследовали концентрацию методом пламенной фотометрии Забор слюны проводился 7, 11, 15, 19 23 часа. Для...
Abstract The incidence of food addiction (FA) and associations between FA anthropometric psycho‐emotional characteristics young Russian adults were studied. In this study, 1,237 students (age, M = 20.6, SD 4.6 years; 79% females) universities located in four cities Russia attended. They provided demographics filled the Yale Food Addiction Scale (YFAS), Dutch Eating Behavior Questionnaire, Zung Self‐Rating Depression Scale. Data analysed via Chi‐squared tests, logistic regression analysis, an...
Primary open-angle glaucoma as a causal factor for circadian disruption: Living by the clock, in alignment with external time cues is an important condition human health and well-being. Periodic changes ambient light serve key to synchronize endogenously generated rhythms. The retina perceives photic signals transmits them central body suprachiasmatic nuclei (SCN), via retinohypothalamic tract. open angle (POAG) optic neuropathy, which disease progression can be monitored assessing damage...