Tatiana L. Ushakova
A5020312612- Ocular Oncology and Treatments
- Cancer-related Molecular Pathways
- Brain Metastases and Treatment
- Corneal Surgery and Treatments
- Nonmelanoma Skin Cancer Studies
- Bacteriophages and microbial interactions
- Retinal Diseases and Treatments
- Head and Neck Surgical Oncology
- Hedgehog Signaling Pathway Studies
- Neonatal Health and Biochemistry
- Ocular Disorders and Treatments
- Retinal Development and Disorders
- Glioma Diagnosis and Treatment
- Renal and related cancers
- Nail Diseases and Treatments
- Toxic Organic Pollutants Impact
- Aquaculture disease management and microbiota
- Microtubule and mitosis dynamics
- Hematopoietic Stem Cell Transplantation
- Ubiquitin and proteasome pathways
- Cytomegalovirus and herpesvirus research
- Infections and bacterial resistance
- Ear and Head Tumors
- Ocular Infections and Treatments
- Chemotherapy-related skin toxicity
Russian Medical Academy of Continuous Professional Education
2020-2024
Siberian Branch of the Russian Academy of Sciences
2023-2024
Institute of Chemical Biology and Fundamental Medicine
2023-2024
L V Prasad Eye Institute
2024
National Medical Research Center of Cardiology
2024
Russian Cancer Research Center NN Blokhin
2017-2022
University College London
2021
Masaryk University
2021
N.N. Alexandrov National Cancer Centre
2021
Children's Clinical University Hospital
2021
PurposeTo compare metastasis-related mortality, local treatment failure, and globe salvage after retinoblastoma in countries with different national income levels.DesignInternational, multicenter, registry-based retrospective case series.ParticipantsTwo thousand one hundred ninety patients, 18 ophthalmic oncology centers, 13 on 6 continents.MethodsMulticenter data were pooled from patients enrolled between January 2001 December 2013. Adequate to allow American Joint Committee Cancer staging,...
To evaluate the ability of American Joint Committee on Cancer (AJCC) 8th edition to predict local tumor control and globe salvage for children with retinoblastoma (RB).International, multicenter, registry-based retrospective case series.A total 2854 eyes 2097 patients from 18 ophthalmic oncology centers 13 countries over 6 continents.International, data were pooled enrolled between January 2001 December 2013. All RB adequate records allow staging by AJCC criteria follow-up ascertain...
To evaluate the ability of 8th edition American Joint Committee on Cancer (AJCC) Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma (RB).International, multicenter, registry-based retrospective case series.A total 2190 patients from 18 ophthalmic oncology centers 13 countries over 6 continents.Patient-specific data fields RB were designed selected by subcommittee. All adequate records allow tumor staging AJCC criteria follow-up disease...
AIM: To determine which IIRC scheme was used by retinoblastoma centers worldwide and the percentage of D eyes treated primarily with enucleation versus globe salvaging therapies as well to correlate trends in treatment choice version geographic region. METHODS: An anonymized electronic survey offered 115 physicians at 39 asking about classification schemes patterns between 2008 2012. Participants were asked record for classification, how many group diagnosed, therapies. Averages per modality...
High-risk histopathologic features of retinoblastoma are useful to assess the risk systemic metastasis. In this era globe salvage treatments for retinoblastoma, definition high-risk is evolving.To evaluate variations in metastasis different ocular oncology practices around world.An electronic web-based, nonvalidated 10-question survey was sent December 2020 52 oncologists and pathologists treating at referral centers.Anonymized about retinoblastoma.High-risk that determine further treatment...
To determine the value of clinical features for advanced intraocular retinoblastoma as defined by eighth edition American Joint Committee on Cancer (AJCC) cT3 category and AJCC Ophthalmic Oncology Task Force (OOTF) Size Groups to predict high-risk pathologic features.International, multicenter, registry-based retrospective case series.Eighteen ophthalmic oncology centers from 13 countries over 6 continents shared evaluations 942 eyes enucleated primary treatment and, comparison, cT2...
Background: The relationship between lag time and outcomes in retinoblastoma (RB) is unclear. In this study, we aimed to study the effect of onset symptoms diagnosis countries based on their national-income analyse its outcomes. Methods: We performed a prospective 692 patients from 11 RB centres 10 1 January 2019 31 December 2019. Results: following factors were significantly different among level: age at (p = 0.001), distance home nearest primary healthcare centre 0.03) mean detection first...
To evaluate presenting features, tumor size, and treatment methods for risk of metastatic death due to advanced intraocular retinoblastoma (RB).International, multicenter, registry-based retrospective case series.A total 1841 patients with RB.Advanced RB was defined by 8th edition American Joint Committee on Cancer (AJCC) categories cT2 cT3 new AJCC-Ophthalmic Oncology Task Force (OOTF) Size Groups (1: < 50% globe volume, 2: > but 2/3, 3: 4: diffuse infiltrating RB). Treatments were primary...
Aeromonas salmonicida is the causative agent of septicemia in fish, and it associated with significant economic losses aquaculture industry. While piscine infections are mainly treated antibiotics, emergence resistance bacterial populations requires development alternative methods treatment. The use phages can be one them. A novel A. jumbo phage, AerS_266, was isolated characterized. This phage infects only mesophilic strains demonstrates a slow lytic life cycle. Its genome contains 243,674...
Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 December 2013. 1054 eyes with vitreous or subretinal seeds 18 ophthalmic oncology centres, in 13 countries within six continents analysed. Local treatment failure was defined as use secondary...
Background Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk abandoning remain unclear. This study aims to identify the factors across multinational set patients. Methods A prospective, observational 692 patients from 11 RB centres in 10 countries was conducted 1 January 2019 31 December 2019. Multivariate logistic regression used associated with higher rates abandonment. Results Logistic...
Our aim was to identify RB1 alterations causing hereditary low penetrance retinoblastoma and evaluate how the parental origin of an mutation affects its phenotypic expression. By NGS MLPA, mutations were found in 191 from 332 unrelated patients. Among patients with identified but without clinical family history retinoblastoma, 7% (12/175) have disease one parents being asymptomatic carrier mutation. Additionally, two families history, inherited by probands unaffected parents. Overall, nine...
Hematopoietic stem cell transplantation (HSCT) is a treatment modality for number of severe malignant and non-neoplastic diseases. Autologous hematopoietic (auto-HSCT) improves outcomes in patients with solid hematological malignancies. Skin lesions at the auto-HSCT stage are quite common represent an important diagnostic therapeutic problem. The most significant causes skin drug toxicity, infectious viral lesions. Each complications can manifest itself to varying degrees as well combine...
Purpose. This research is to evaluate patients with retinoblastoma, who receive chemotherapy, Spectralis optical coherence tomography enhanced depth imaging compare the signs of chorioretinopathy and maculopathy. Material methods. 74 were examined treated, 125 eyes retinoblastoma in age at average 24 ± 1.6 months. Group 1 - 31 patients, 62 after intravenous 2 25 superselective intraarterial or intravitreal chemotherapy. 3 (control) 19 (38 eyes) primary retinoblastoma. The condition retina,...
Little is known regarding differences in childhood growth between somatic and heritable retinoblastoma (Rb) populations. We aimed to compare parameters Rb cohorts at birth time of diagnosis with Rb.
Bacteria of the
To investigate the outcomes of primary enucleation and adjuvant systemic chemotherapy, when deemed appropriate, on a cohort children with unilateral intraocular Rb (AJCC 8th edition, cT2 cT3) from diverse economic groupings. A prospective analysis including treatment-naïve patients were presented to 11 centers 10 countries January 1 December 31, 2019, followed-up thereafter. Only that underwent included in present analysis. Systemic metastasis survival investigated. Of 692 Rb, 191 (27.6%)...
The protective effects of breastfeeding on various childhood malignancies have been established but an association has not yet determined for retinoblastoma (RB). We aimed to further investigate the role in severity nonhereditary RB development, assessing relationship (1) age at diagnosis, (2) ocular prognosis, measured by International Intraocular Classification (IIRC) or (ICRB) group and success eye salvage, (3) extraocular involvement. Analyses were performed a global dataset subgroup 344...
Purpose: To assess histopathology and outcomes following primary enucleation of eyes with retinoblastoma presenting neovascular glaucoma (NVG). Methods: This was an international multi-centre case series study across five continents. Retrospective review patient charts performed for all patients undergoing (n=1420) using a standardised data-collection spreadsheet. Clinical features, pathological grade, were compared between NVG those American Joint Commission on Cancer (AJCC) 8 th edition...
ABSTRACT Background To evaluate the clinical presentation, pathological features and outcomes of retinoblastoma based on race origin in a global cohort patients. Methods Retrospective collaborative study 1426 patients who underwent primary enucleation for retinoblastoma. Results Patients were grouped into Caucasians ( n = 231, 16%), Asians 841, 59%), Hispanics 226, Arabs 96, 7%) Others (Africans, African Americans, Indigenous Australians; 32, 2%) cohorts. On histopathology, massive choroidal...
Abstract Background/Objectives Retinoblastoma is a common childhood intraocular malignancy, the bilateral form of which most commonly results from de novo germline pathogenic variant in RB1 gene. Both advanced maternal age and decreasing birth order are known to increase risk variants, while influence national wealth understudied. This cohort study aimed retrospectively observe whether these factors ratio retinoblastoma cases compared unilateral retinoblastoma, thereby inferring an on...
Актуальность. При наследственной ретинобластоме герминальная мутация в одном из аллелей гена RB1 обусловливает предрасположенность к заболеванию и его семейную передачу. Наследственная ретинобластома манифестирует более раннем возрасте по сравнению со спорадической формой носит большинстве случаев мультифокальный билатеральный характер. Однако некоторые семьи с ретинобластомой (два носителя одинаковой герминальной мутации родословной) демонстрируют мягкий фенотип неполной пенетрантностью (у...