Kalle Nummi
A5048908167- Ocular Oncology and Treatments
- Brain Metastases and Treatment
- Corneal Surgery and Treatments
- Nonmelanoma Skin Cancer Studies
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Alcoholism and Thiamine Deficiency
- Vitamin C and Antioxidants Research
- Pharmacology and Obesity Treatment
- Retinal Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
- Electrolyte and hormonal disorders
- Neuroscience and Neuropharmacology Research
- Retinal and Macular Surgery
- Liver Disease Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Diet and metabolism studies
Helsinki University Hospital
2017-2022
University of Helsinki
2020-2022
Oulu Deaconess Institute
1993
PurposeTo compare metastasis-related mortality, local treatment failure, and globe salvage after retinoblastoma in countries with different national income levels.DesignInternational, multicenter, registry-based retrospective case series.ParticipantsTwo thousand one hundred ninety patients, 18 ophthalmic oncology centers, 13 on 6 continents.MethodsMulticenter data were pooled from patients enrolled between January 2001 December 2013. Adequate to allow American Joint Committee Cancer staging,...
To evaluate the ability of American Joint Committee on Cancer (AJCC) 8th edition to predict local tumor control and globe salvage for children with retinoblastoma (RB).International, multicenter, registry-based retrospective case series.A total 2854 eyes 2097 patients from 18 ophthalmic oncology centers 13 countries over 6 continents.International, data were pooled enrolled between January 2001 December 2013. All RB adequate records allow staging by AJCC criteria follow-up ascertain...
To evaluate the ability of 8th edition American Joint Committee on Cancer (AJCC) Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma (RB).International, multicenter, registry-based retrospective case series.A total 2190 patients from 18 ophthalmic oncology centers 13 countries over 6 continents.Patient-specific data fields RB were designed selected by subcommittee. All adequate records allow tumor staging AJCC criteria follow-up disease...
To determine the value of clinical features for advanced intraocular retinoblastoma as defined by eighth edition American Joint Committee on Cancer (AJCC) cT3 category and AJCC Ophthalmic Oncology Task Force (OOTF) Size Groups to predict high-risk pathologic features.International, multicenter, registry-based retrospective case series.Eighteen ophthalmic oncology centers from 13 countries over 6 continents shared evaluations 942 eyes enucleated primary treatment and, comparison, cT2...
To evaluate presenting features, tumor size, and treatment methods for risk of metastatic death due to advanced intraocular retinoblastoma (RB).International, multicenter, registry-based retrospective case series.A total 1841 patients with RB.Advanced RB was defined by 8th edition American Joint Committee on Cancer (AJCC) categories cT2 cT3 new AJCC-Ophthalmic Oncology Task Force (OOTF) Size Groups (1: < 50% globe volume, 2: > but 2/3, 3: 4: diffuse infiltrating RB). Treatments were primary...
Zuclopenthixol acetate--a new injectable formulation with a duration of action 2-3 days--was compared conventional intramuscular and oral formulations haloperidol zuclopenthixol in the initial treatment acutely disturbed, psychotic patients. The patients were stratified into 3 diagnostic categories: acute psychoses (48 patients), mania (22 exacerbation chronic (73 patients). rated on Brief Psychiatric Rating Scale (BPRS), Bech-Rafaelsen Mania (BRMAS) (only manic patients) globally Clinical...
Aims To determine the incidence of retinoblastoma (Rb) and subsequent survival in Finnish population during five decades. Methods This retrospective observational cohort study comprised all patients with Rb born Finland 1964 – 2014 diagnosed 2018 (birth analysis) or (standard annual analysis), identified from Cancer Registry national referral centre. We report age-adjusted incidences according to cause death. Results Of children 2014, 205 developed Rb, whereas 204 Rbs were these years; 196...
Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 December 2013. 1054 eyes with vitreous or subretinal seeds 18 ophthalmic oncology centres, in 13 countries within six continents analysed. Local treatment failure was defined as use secondary...
There appears no clear consensus about what dose of thiamine is best indicated for the treatment acute Wernicke encephalopathy. Clinical textbooks and some literature refer to doses 50–100 mg being required even though these exceed recommended daily nutritional requirement. Recently, in Australia, a trend toward giving higher has been observed, e.g. 200 three times daily, often parenterally administered. Data are presented from survey hospital physicians indicating that encephalopathy still...
Purpose Retinoblastoma (Rb), a malignancy of developing retina, emerges almost always after biallelic mutation and inactivation tumor suppressor gene RB1. In heritable Rb, child carries germline RB1 mutation. Identifying this will help in future risk management family planning. Recently, we have made an effort to create comprehensive national register for Rb. DNA sequencing mutations is being offered every patient not previously tested the results are included register. Methods Of 226 Rb...