A5089685125- Ocular Oncology and Treatments
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Census and Population Estimation
- Intracranial Aneurysms: Treatment and Complications
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Statistics Education and Methodologies
- melanin and skin pigmentation
- Cancer-related Molecular Pathways
- Advanced Statistical Methods and Models
- Corneal Surgery and Treatments
- Cancer and Skin Lesions
- Intracerebral and Subarachnoid Hemorrhage Research
- Protein Degradation and Inhibitors
- Assisted Reproductive Technology and Twin Pregnancy
- Glaucoma and retinal disorders
- Ocular Disorders and Treatments
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Data-Driven Disease Surveillance
Royal Children's Hospital
2014-2024
The Royal Victorian Eye & Ear Hospital
2001-2024
Babson College
2001-2015
Cleveland Clinic
1995-2004
Sydney Hospital
2004
Cleveland Eye Clinic
2004
Royal Hallamshire Hospital
2004
Karolinska Institutet
2004
Peter MacCallum Cancer Centre
2003
St Vincent’s Private Hospital Sydney
2003
Abstract Previous studies examining sun exposure and ocular melanoma have produced inconsistent results. We investigated this association in a population‐based case‐control study Australia. Cases ( n = 290) aged 18–79 years were diagnosed between January 1996 July 1998. Controls 893) randomly selected from the electoral rolls frequency‐matched to cases by age, sex state. A self‐administered questionnaire telephone interview measured on weekdays weekends at 10, 20, 30 40 of age over whole...
Abstract Routinely collected incidence data have often lacked specific identification of ocular melanoma in the past and with increasing diagnosis management this disease by noninvasive techniques may now underestimate true incidence. We attempted to accurately measure Australia from 1990 1998 using 2 population‐based sources, cancer registries ophthalmologists. examined distribution across continent, latitude subpopulations, evaluated extent nonnotification registries. One‐half (51%)...
Ethnicity, cutaneous nevi and eye color are generally accepted risk factors for melanoma of the eye, although case-control studies have produced conflicting results. We sought to determine constitutional melanomas choroid, ciliary body, iris conjunctiva in Australia. A population-based study was conducted, with case ascertainment from a prospective national incidence survey randomly selected community controls. Two hundred ninety cases aged 18–79 years diagnosed between 1st January 1996 31st...
The purpose of this article is to report on the safety and effectiveness brain arteriovenous malformation (AVM) embolization for two series patients, which one was treated with particulate other acrylic embolization. Sixty-five consecutive patients from logs patient records 1988 1993 were reviewed. AVMs routinely early in review (1988-1991), after a transition period, technique changed remainder study period (1992-1993). All ultimate goal complete AVM obliteration. embolized resected, if...
Five children with an orbital recurrence of retinoblastoma have been successfully treated by a combination excision biopsy the tumour mass, radical radiotherapy, and systemic chemotherapy. Nine previous children, consecutive five presented here, died from disseminated after failure earlier treatment programmes for recurrence. An aggressive therapeutic approach is justified this improvement in survival.
High-risk histopathologic features of retinoblastoma are useful to assess the risk systemic metastasis. In this era globe salvage treatments for retinoblastoma, definition high-risk is evolving.To evaluate variations in metastasis different ocular oncology practices around world.An electronic web-based, nonvalidated 10-question survey was sent December 2020 52 oncologists and pathologists treating at referral centers.Anonymized about retinoblastoma.High-risk that determine further treatment...
Abstract We examined risk of ocular melanoma with exposure to artificial sources ultraviolet radiation (UVR) in a population‐based epidemiologic study 290 cases and 893 controls aged 18–79 years Australia 1996–1998. Cases were identified through prospective survey all ophthalmologists cancer registries Australia; 91.8% participated. Controls sourced from electoral rolls; 67.4% those who eligible contactable participated, while 27.3% could not be contacted. Exposure welding use sunlamps,...
Describe the symptoms, signs, radiographic findings, and treatment results for four patients with intralabyrinthine schwannoma beginning either primarily within labyrinth or extending secondarily into from internal auditory canal.Retrospective review.Review of clinic records, operative imaging studies follow-up telephone interview, when possible, repeat examination.Four treated by first author were identified. Episodic vertigo, indistinguishable Meniere's disease, was present in all but one...
This study aimed to describe tumour identification on magnetic resonance imaging (MRI) in a 35-week fetus with familial retinoblastoma (RB) and report the use of prenatal ultrasound (US) MRI screening management fetuses at high risk RB.This is retrospective review course immediate postnatal findings all children considered RB who had both US our institution over 5-year period.Five patients met inclusion criteria. No lesions were identified any patients. Fetal bilateral posterior pole one...
Abstract Purpose: To describe changes in the management of retinoblastoma Victoria and to review effect newer, conservative treatments on preservation eyes, visual outcome mortality by comparing a similar group patients treated over successive time intervals. Methods: A retrospective analysis all cases diagnosed between 1956 2000 was conducted. Historical data 77 previously published O’Day et al. used for period 1956−1976 (series 1). Data 88 recorded Royal Children's Hospital (Melbourne)...
A review of the experience at Peter MacCallum Cancer Centre (Peter Mac), Melbourne, Australia in treating retinoblastoma with external beam radiotherapy was conducted. Outcomes particular interest were tumour control, vision preservation and treatment late effects. The restricted to patients that had intact eyes treated Mac from 1965 until 1997 least 2 years follow up. Histories reviewed regarding patient characteristics details. Thirty-five identified whom 47 treated. Of tumours, 47%...
9510 Background: Darovasertib is a protein kinase C (PKC) inhibitor with meaningful activity in metastatic uveal melanoma (UM) due to its effect on PKC delta downstream of canonical GNAQ/GNA11 mutations. To date, clinical patients localized primary disease has not been assessed either neoadjuvant or adjuvant settings. Methods: Patients planned for enucleation UM were treated an initial safety cohort darovasertib 300mg BID 1 month (n=3 patients), and then following DSMB agreement expansion up...
TPS9612 Background: Darovasertib (Daro) is a novel inhibitor of PKC, that has pre-clinical activity in GNAQ/GNA11 tumours including ocular melanoma. A recently completed clinical trial Daro monotherapy metastatic OM with response rate 11%, and DCR 78% only mild manageable toxicity, suggesting utility localized disease the adjuvant setting. Methods: NADOM an investigator-initiated window-of-opportunity phase 2 open 3 centers across Australia. Eligible patients include planned for enucleation,...
Beginning with the 75th Anniversary of American Statistical Association in 1914 and for subsequent 25-year celebrations, distinguished members association have addressed future statistics. A four-person panel engaged same exercise during 2014 Joint Meetings ASA's dodransbicentennial. The identified a variety strengths, weaknesses, opportunities, threats profession next quarter century. This article highlights some discussion that took place.
The aim of the present study was to test hypothesis that adjunctive local anaesthesia decreases postoperative pain, vomiting or length stay in children having strabismus repairA prospective, randomized, triple-armed clinical trial involving a treatment comparison between topical amethocaine, sub-conjunctival bupivacaine and, as placebo, normal saline performed. All treatments were given at end surgery before emergence from anaesthetic.Overall, there no statistically significant difference...
Summary We explain how to simulate both univariate and bivariate raw data sets having specified values for common summary statistics. The first example illustrates ‘construct’ a set prescribed the mean standard deviation – one‐sample t test with outcome. second shows create correlation coefficient.