M V Budzinskaya
A5038780008- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Neurological Disorders and Treatments
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Cerebral Venous Sinus Thrombosis
- Photodynamic Therapy Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Angiogenesis and VEGF in Cancer
- Cerebrovascular and Carotid Artery Diseases
- Optical Coherence Tomography Applications
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Ocular Surface and Contact Lens
- Complement system in diseases
- Corneal Surgery and Treatments
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Advanced Glycation End Products research
- Connexins and lens biology
- Ocular Oncology and Treatments
- Retinopathy of Prematurity Studies
Federal State Scientific Institution Research Institute of Eye Diseases
2017-2024
Insight (China)
2024
Tver State Medical University
2020
Helmholtz Moscow Research Institute of Eye Diseases
2002-2019
Prokhorov General Physics Institute
2004
PurposeTo evaluate 2-year efficacy, durability, and safety of the bispecific antibody faricimab, which inhibits both angiopoietin-2 VEGF-A.DesignTENAYA (ClinicalTrials.gov identifier, NCT03823287) LUCERNE NCT03823300) were identically designed, randomized, double-masked, active comparator-controlled phase 3 noninferiority trials.ParticipantsTreatment-naive patients with neovascular age-related macular degeneration (nAMD) 50 years age or older.MethodsPatients randomized (1:1) to intravitreal...
Age-related macular degeneration (AMD) develops in people aged 50 years and older, its pathogenesis involves progressive destruction of the retinal pigment epithelium Bruch's membrane. There are eight currently known anti-VEGF drugs for treating neovascular form AMD, four them have already been registered used clinical practice. The first drug was pegaptanib, which selectively blocks VEGF165. Subsequently, a molecule with similar mechanism action developed named ranibizumab, is humanized...
The article analyses current state of the problem diabetic retinopathy classifications based on data from Russian and foreign literature pathogenesis, clinical manifestations, results multicenter studies treatment prognosis disease. Every existing classification was found to be limited in applications; attempts had been made unify complement them with aim achieving more complete better-detailed description processes diagnostics determination algorithms. In conclusion, none can considered...
AIM: To study antibiotic resistance patterns and susceptibility to eye antiseptic picloxydine of conjunctival flora in patients undergoing intravitreal injections (IVIs). METHODS: Conjunctival swabs were taken 4 groups patients, 20 each group (n=80): without IVIs ophthalmic operations history (group N1; control group); with the first IVI drops Tobrex applied 3d before 5d after it N2); or more repeated courses N3); Vitabact (picloxydine) N4). In N2 N4 at baseline treatment. Efficacy...
Age-related macular degeneration is one of the leading causes visual deterioration in world. There are currently about 30 million people with this pathology. The main factors stimulating development neovascularization and corneal edema hypoxic patients production VEGF - blocking them goal anti-VEGF therapy. High efficacy therapy was demonstrated pivotal Phase III trials such as MARINA, ANCHOR VIEW 1&2 which gave basis to registration drugs further wide use clinical practice. Along that...
Intravitreal injection (IVI) of anti-angiogenic drugs is one the most common therapeutic procedures in ophthalmology. In recent years, a new non-contact study method has been developed - anterior segment optical coherence tomography (AS-OCT), which allows formation three-dimensional images lens and provides more detailed information about its structure morphology.
Importance Biosimilars may be lower-cost alternatives to originator biologic products, potentially offering expanded access or reduced economic burden, but have not been evaluated with aflibercept in diabetic macular edema (DME). Objective To compare efficacy and safety of MYL-1701P, an biosimilar, reference (Eylea [Regeneron]) DME. Design, Setting, Participants This was a double-masked, randomized clinical trial that included participants at 77 centers across the US, Europe, Japan, India....
Myopia prevalence grows alike in many countries, including Russia, regardless of geographical and population conditions.to assess fundus changes myopic patients at different ocular axial lengths by means modern diagnostic tools.The study enrolled 97 (194 eyes) aged 45 ± 20.17 years with myopia degrees. Besides a standard ophthalmic examination, all underwent fluorescein angiography optical coherence tomography.The occurrence retinal pigment epithelium (RPE) atrophy (diffuse or focal) has...
To investigate the relationship between OCT angiography measurements and central fundus changes in patients with retinal vein occlusion (RVO).The study enrolled 21 RVO aged from 55 to 86 years (69.9±2.28 years), including 8 ischemic (I-CRVO; 73.6±3.4 on average) 13 branch (BRVO; 67.6±3.0 average). Of latter, cases were (I-BRVO) 5 non-ischemic (NI-BRVO). (OCTA) was performed using RTVue XR Avanti (Optovue, USA) tomograph Angio Retina mode.A direct correlation found visual acuity degree of...
A data analysis on the actual direction of biomedicine, study biomarkers in diabetic retinopathy (DR), was done. Biomarkers identification is important for screening, diagnosis, monitoring, prevention and prediction clinical response patient to treatment. In addition, studying allows increase effectiveness safety using various treatment options. The review examines two main groups biomarkers, molecular visualised, which shows current state problem prospects context DR Nowadays, searching...
Intravitreal drug administration is a procedure that has become widespread in modern ophthalmology. However, there no global consensus on certain aspects of this manipulation, and practitioners feel the need for guidelines. In Russian Federation, until now, such document was not available. The expert council diseases retina optic nerve All-Russian public organization «Association Ophthalmologists», with participation invited specialists, studied analyzed existing foreign guidelines...
There are currently no reliable biomarkers for predicting the response to treatment of diabetic macula edema (DME).To asses predictive role neurodegenerative biomarker anti-VEGF therapy DME.Examination and was carried out on 14 patients (20 eyes) with DME. The eyes were divided into 2 groups by type diabetes: 6 1 diabetes diabetes. duration 16.5±7.9 years, level glycated hemoglobin 8.4±2%. A number indicators evaluated using optical coherence tomography (OCT) in order determine treatment....
To study the effect of ranibizumab and aflibercept on thickness retinal nerve fiber layer (RNFL) in patients with neovascular age-related macular degeneration (nAMD) primary open-angle glaucoma (POAG).The included 62 (62 eyes) nAMD comorbid POAG. Patients were divided into two groups depending anti-VEGF treatment. The first group 42 (42 who received injections ranibizumab. second consisted 20 (20 aflibercept. All three or one-month intervals. In addition to standard ophthalmic examination,...
To evaluate the effectiveness of anti-angiogenic therapy using fluctuation and variability in patients with exudative age-related macular degeneration (AMD).This study included 200 types 1, 2, 3 neovascularization polypoidal choroidal vasculopathy (PCV). All underwent standard ophthalmological examination, as well optical coherence tomography (OCT) OCT angiography (OCT-A). Patients were divided into 4 quartiles based on variability. intravitreal administration anti-VEGF drug aflibercept...