A5059187818- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Corneal surgery and disorders
- Connexins and lens biology
- Systemic Lupus Erythematosus Research
- CRISPR and Genetic Engineering
- Diabetes and associated disorders
- Biosimilars and Bioanalytical Methods
- Ocular Oncology and Treatments
- Complement system in diseases
- Ocular Infections and Treatments
- Digital Imaging for Blood Diseases
- RNA Interference and Gene Delivery
- Diabetes Management and Research
- Nanocluster Synthesis and Applications
- Neuroscience and Neural Engineering
- Corneal Surgery and Treatments
University Hospital Kralovske Vinohrady
2016-2025
Charles University
2018-2024
Insight (China)
2024
Neovascular age-related macular degeneration is the leading cause of blindness in individuals 50 years or older. The availability a ranibizumab biosimilar product (SB11) may facilitate access to an effective alternative this treatment.To demonstrate equivalence efficacy, similar safety, and immunogenicity SB11 compared with reference ranibizumab.This randomized, double-masked, parallel-group phase 3 study was conducted 75 centers 9 countries from March 14, 2018, December 9, 2019, among 705...
Importance Aflibercept biosimilars can expand available treatment options in retinal diseases and have the potential to improve patient access safe effective therapy. Objective To establish equivalence efficacy similarity safety, pharmacokinetics, immunogenicity of SB15 reference aflibercept (AFL) neovascular age-related macular degeneration (nAMD). Design, Setting, Participants This was a randomized double-masked parallel group phase 3 trial conducted at 56 centers 10 countries from June...
Aims/Purpose: The study of long‐term survival transplanted retinal pigment epithelium (RPE) in animal models is very important for the development promising cell‐based therapy degenerative diseases such as age‐related macular degeneration (AMD) or retinitis pigmentosa. We hereby present xenogeneic implantation human iPSC‐RPEs into minipig eyes with a 6‐week follow‐up period. Methods: subretinal implantations hiPSC‐RPEs‐scaffolds were performed using 3‐port pars plana vitrectomy. character...
In late stages of inherited and acquired retinal diseases such as Stargardt disease (STGD) or dry age-related macular degeneration (AMD), loss pigment epithelia (RPE) cells subsequently photoreceptors in the area result a dramatic decline central visual function. Repopulating this with functional RPE may prevent progression photoreceptor loss. present study, viability, survival, integration human induced pluripotent stem cell (hiPSC)-derived (hiPSC-RPE) is assessed generated using...
To provide longer-term data on efficacy, safety, immunogenicity and pharmacokinetics (PK) of ranibizumab biosimilar SB11 compared with the reference (RBZ) in patients neovascular age-related macular degeneration (nAMD).Setting: Multicentre. Design: Randomised, double-masked, parallel-group, phase III equivalence study. Patient population: ≥50 years old participants nAMD (n=705), one 'study eye'.1:1 randomisation to monthly intravitreal injection 0.5 mg or RBZ. Main outcome measures: Visual...
Purpose. To compare the effect of different types intraocular tamponade and postoperative positioning on closure idiopathic macular hole (IMH). Methods. Prospective randomized clinical trial enrolling 104 eyes 100 patients (age, 57–87 years) undergoing MH surgery. All were operated by an experienced surgeon using 25-gauge pars plana vitrectomy (PPV) internal limiting membrane (ILM) peeling. Patients according to type into following four groups: SF6 + nonsupine reading position (n = 26)...
Importance Biosimilars may be lower-cost alternatives to originator biologic products, potentially offering expanded access or reduced economic burden, but have not been evaluated with aflibercept in diabetic macular edema (DME). Objective To compare efficacy and safety of MYL-1701P, an biosimilar, reference (Eylea [Regeneron]) DME. Design, Setting, Participants This was a double-masked, randomized clinical trial that included participants at 77 centers across the US, Europe, Japan, India....
To evaluate efficacy, safety, pharmacokinetics (PK) and immunogenicity of SB15 versus reference aflibercept (AFL), switching from AFL to in neovascular age-related macular degeneration (nAMD).
To present a cohort of treatment-naive patients with the neovascular form age-related macular degeneration (nAMD) treated aflibercept in fixed regimen and evaluate treatment response three types choroidal membrane (CNV)-occult (Type 1), classic 2), minimally 4).This was multicentre, prospective, observational consecutive case series study. Patients diagnosed CNV nAMD were (3 injections every 4 weeks, then at 8 week intervals). The follow-up period 48 weeks. Best-corrected visual acuity...
Aim To evaluate the incidence of ocular adverse events after loading phase brolucizumab therapy in patients with neovascular age-related macular degeneration (nAMD) real-life clinical practice – treatment-naive and switching from another anti-VEGF agent. Another aim was to treatment outcomes events. Methods This is a multicentre, retrospective, observational study 16 application centres Czech Republic. Patients diagnosed nAMD were treated fixed regimen (3 injections administered at one-month...
Aim: To present the results of a 2-year therapy with aflibercept in real-life practice mixed regimen patients neovascular form age-related macular degeneration (nAMD) and to evaluate treatment response various types choroidal membranes (CNV) – occult (Type 1), classic 2) minimally 4). Methods: This was multicentric, prospective, observational study series cases. Patients diagnosed wet AMD were treated fixed (3 injections at intervals 1 month then 8-week intervals) first year, pro re nata...
To evaluate the anatomical and functional results in patients with rhegmatogenous retinal detachment (RRD) who underwent 25-gauge pars plana vitrectomy (PPV) gas tamponade.A retrospective evaluation of 126 eyes (79 men, 47 women) RRD PPV tamponade (13% C3F8 87 eyes, 20% SF6 39 eyes). 113 (89.7%), were operated on under local anaesthesia, 13 (10.3%) general anaesthesia. Macula was detached 85 (67.5%). 53 had pseudophakic RRD, 73 phakic. Anatomical success primary intervention, change best...
Cíl: Retrospektivní hodnocení prvních 12 měsíců léčby makulárního edému u okluze větve sítnicové žíly (BRVO) preparátem ranibizumab na základě anatomických a funkčních
Abstract Background To present a case report of patient with mixed choroidal neovascular membrane (CNV) an asymmetric response to ranibizumab diagnosed on optical coherence tomography angiography (OCTa). Case presentation A 61-year-old male was referred our department in September 2017 due decreased vision his left eye. Best-corrected visual acuity (BCVA) 43 Early Treatment Diabetic Retinopathy Study (ETDRS) letters the Macular edema eye, and CNV identified OCTa. Therapy intravitreal...
Purpose: Purpose of this article is to present a case report patient with uveal effusion syndrome who underwent deep posterior sclerotomy. Case report: A 73-year-old unilateral decrease in the best corrected visual acuity, ablation choroid and secondary retinal detachment right eye was admitted our clinic for examination November 2017. At first examination, acuity 0.3, left 1.0. Intraocular pressure 16 mmHg 21 eye. After performing ultrasound biomicroscopy anterior segment (Accutome, Keeler,...
Abstract Retinal detachment is an acute condition in ophthalmology that needs immediate surgical management. The treatment requires a replacement of the vitreous with temporary substitute, usually based on silicone oil. A certain number patients experience adverse events during treatment. It seems this phenomenon related to formation emulsions affected eye. These appear macroscopically as heterogeneities resembling small droplets patchy occurrence substitute. Their existence represents major...
Aim: Retinal detachment is an acute sight-threatening condition that requires immediate surgical intervention. The aim of this study to compare the outcomes pars plana vitrectomy (PPV) for uncomplicated rhegmatogenous retinal (RRD) between different types gases used, position, and number tears. Material Methods: This a retrospective non-randomized comparative patients with RRD treated at Department Ophthalmology from March 2018 April 2021 using PPV. A total 494 evaluated eyes were included...