A5015594836- Traumatic Brain Injury and Neurovascular Disturbances
- Neutrino Physics Research
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Epilepsy research and treatment
- Particle physics theoretical and experimental studies
- Trauma and Emergency Care Studies
- Cerebral Venous Sinus Thrombosis
- Particle Detector Development and Performance
- Astrophysics and Cosmic Phenomena
- Neurological Complications and Syndromes
- Acute Ischemic Stroke Management
- Pain Mechanisms and Treatments
- Brain Metastases and Treatment
- Hospital Admissions and Outcomes
- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Nursing Roles and Practices
- Peripheral Neuropathies and Disorders
- Trauma Management and Diagnosis
- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
Westchester Medical Center
2022-2025
Johannes Gutenberg University Mainz
2022-2025
Brigham and Women's Hospital
2014-2024
New York Medical College
2022-2024
California University of Pennsylvania
2024
Massachusetts General Hospital
2014-2023
University of Pennsylvania
2020-2023
Harvard University
2009-2022
Center for Neuro-Oncology
2021
Dana-Farber Cancer Institute
2021
Spinal cord injury (SCI) can result in hyperexcitability of dorsal horn neurons and central neuropathic pain. We hypothesized that these phenomena are consequences, part, dysregulated expression voltage-gated sodium channels. Because the rapidly repriming TTX-sensitive channel Nav1.3 has been implicated peripheral pain, we investigated its role pain after SCI. In this study, adult male Sprague Dawley rats underwent T9 spinal contusion injury. Four weeks when extracellular recordings...
Peripheral nerve injury is known to upregulate the rapidly repriming Na v 1.3 sodium channel within first-order spinal sensory neurons. In this study, we hypothesized that (1) after peripheral injury, second-order dorsal horn neurons abnormally express 1.3, which (2) contributes responsiveness of these and pain-related behaviors. To test hypotheses, adult rats underwent chronic constriction (CCI) sciatic nerve. Ten days CCI, allodynia hyperalgesia were evident. situ hybridization,...
Current treatments for epilepsy may control seizures, but have no known effects on the underlying disease. We sought to determine whether early treatment in a model of genetic would reduce severity phenotype adulthood.We used Wistar albino Glaxo rats Rijswijk (WAG/Rij) rats, an established human absence epilepsy. Oral ethosuximide was given from age p21 5 months, covering usual period which seizures develop this (age approximately 3 months). Two experiments were performed: (1) cortical...
Summary Purpose: Central nervous system plasticity is essential for normal function, but can also reinforce abnormal network behavior, leading to epilepsy and other disorders. The role of altered ion channel expression in has not been thoroughly investigated. Nav1.6 the most abundantly expressed sodium system. Because its distribution cell body axon initial segment, crucial action potential generation. goal present study was investigate possible changes abnormal, activity‐dependent...
Intracranial pressure (ICP) monitoring (ICPM) is currently recommended for severe traumatic brain injury (TBI). The hypothesis was that ICPM does not change mortality in the geriatric patient population. Trauma Quality Improvement Program (TQIP) database (2017-2021) queried to identify intubated patients (≥65 years of age) with isolated blunt TBI (non-Head Abbreviated Injury Scale (AIS) score <3), admission Glasgow Coma (GCS) scores 3-8. Patients death on arrival or hospital length stay <24...
Purpose: This study aimed to evaluate early-phase safety of subretinal application AAVanc80.CAG.USH1Ca1 (OT_USH_101) in wild-type (WT) pigs, examining the effects a vehicle control, low dose, and high dose. Methods: Twelve WT pigs (24 eyes) were divided into three groups: four each received bilateral injections either vehicle, dose (3.3 × 1010 vector genomes [vg] per eye), or (1.0 1011 vg eye). Total retinal thickness (TRT) was evaluated using optical coherence tomography function assessed...
Extracorporeal membrane oxygenation (ECMO) has emerged as a critical intervention in the management of patients with trauma-induced cardiorespiratory failure. This study aims to compare outcomes severe thoracic injuries and without venovenous extracorporeal (VV-ECMO). We performed retrospective cohort on Trauma Quality Improvement Program (2017-2021) included all isolated blunt Abbreviated Injury Scale score ≥4 who required intubation. Patients were divided into two groups based VV-ECMO...
Given the high post-stroke mortality and disability paucity of data on quality stroke care in Sub-Saharan Africa, we sought to characterize implementation stroke-focused treatments 90-day outcomes neuroimaging-confirmed patients at largest referral hospital Tanzania.Prospective cohort study.Muhimbili National Hospital (MNH) Dar es Salaam, July 2016-March 2017.Adults with new-onset (<14 days), confirmed by head CT, admitted MNH.Modified Rankin scale (mRS) vital status.Of 149 subjects (mean...
In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons two rodent models nerve injury: sciatic axotomy streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I are preferentially expressed small (< 25 μm diameter) DRG neurons. There is a significant down-regulation IGF-IR STZ rats by 59% 71%, respectively. A parallel reduction shown axotomized < diameter for (47%) but not...
Abstract Peripheral nerve injury induces changes in the level of gene expression for sodium channels Nav1.3, Nav1.8, and Nav1.9 within dorsal root ganglion (DRG) neurons, which may contribute to development hyperexcitability, ectopic neuronal discharge, neuropathic pain. The mechanism this change channel is unclear. Decreased availability neurotrophic factors following axotomy contributes these transcription, but question whether intrinsic activity levels alone can trigger has not been...
Stroke-like migraine attacks after radiation therapy (SMART) syndrome represents a rare but serious condition manifesting years cranial (RT).1 Characterized by migraine-type headaches, stroke-like deficits, seizures, and MRI abnormalities, including cortical gyriform enhancement in irradiated brain regions, SMART is diagnostically therapeutically challenging.2-6 Distinction from tumor progression difficult treatment options are limited.2 Although frequently reversible,5 episodes can recur6...
Neurofibromatosis 2 (NF2) is an autosomal dominant disorder that causes nervous system tumors and ocular abnormalities such as early-onset lenticular opacities. We assessed the clinical spectrum of NF2 at time presymptomatic DNA diagnosis in at-risk first-degree relatives. studied five multigeneration families with short tandem repeat markers near gene (NF2); gadolinium-enhanced high-resolution magnetic resonance imaging (GE-MRI); ocular, dermatologic, neurologic examinations. Eleven 31...
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Background and Objectives: To achieve pregnancy, it is highly beneficial to identify the time of ovulation as well greater period fertile days during which sperm may survive leading up ovulation. Confirming successful also critical accurately diagnose ovulatory disorders. Ovulation predictor kits, fertility monitors, tracking apps are all available assist with detecting ovulation, but often fall short. They not detect full window, provide accurate or real-time information, simply expensive...
We sought to provide an assessment of the burden neurocysticercosis among people with epilepsy (PWE) in Bhutan and evaluate yield various tests for Taenia solium. PWE were enrolled at National Referral Hospital Thimphu (2014–2015). Serum was tested anti-Taenia solium IgG using ELISA (Ab-ELISA), enzyme-linked immunoelectrotransfer blot (EITB), parasite antigen. Results compared brain MRI. Participants categorized as definite (MRI EITB positive), probable or without neurocysticercosis....
A 32-year-old man with daily nitrous oxide inhalant use presented an inability to walk. MRI of the whole spine revealed hyperintensities in posterior spinal cord on T2-weighted images.