A5041156015- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Vascular Malformations Diagnosis and Treatment
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Soft Robotics and Applications
- Retinopathy of Prematurity Studies
- Neuroscience and Neural Engineering
- Intracranial Aneurysms: Treatment and Complications
- Ocular Diseases and Behçet’s Syndrome
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Ocular Disorders and Treatments
- Augmented Reality Applications
- Photoreceptor and optogenetics research
- Renal and Vascular Pathologies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Teleoperation and Haptic Systems
- CRISPR and Genetic Engineering
- Piezoelectric Actuators and Control
- Cellular transport and secretion
- Intracerebral and Subarachnoid Hemorrhage Research
Manchester Royal Eye Hospital
2023-2024
Retina Institute
2012-2023
Retina Consultants of Houston
2022-2023
Houston Methodist
2022-2023
Methodist Hospital
2022-2023
University of Tennessee at Knoxville
2006-2023
University of Tennessee Health Science Center
2006-2018
National Eye Institute
1975-2016
National Institutes of Health
1975-2016
University of Florida Health
2016
Considerable progress has been made in testing stem cell-derived retinal pigment epithelium (RPE) as a potential therapy for age-related macular degeneration (AMD). However, the recent reports of oncogenic mutations induced pluripotent cells (iPSCs) underlie need robust manufacturing and functional validation clinical-grade iPSC-derived RPE before transplantation. Here, we developed mutation-free iPSCs from three AMD patients differentiated them into iPSC-RPE patches on biodegradable...
Purpose: To determine the incidence and clinical features of chronic elevated intraocular pressure after pars plana vitrectomy silicone oil injection for complicated retinal detachments, to evaluate management eyes with secondary glaucoma. Methods: This was an observational consecutive case series 450 in 447 patients who were treated injection. Patients developed glaucoma medically antiglaucoma medications surgically drainage implants placed inferior quadrant. Main outcome measures pressure,...
BACKGROUND AND OBJECTIVE: To present a case series to elucidate novel technique that involves the creation of an arcuate retinotomy in treatment large macular holes after failed primary repair. PATIENTS METHODS: retrospective chart review. Six eyes (six patients) with holes, all which had repair, underwent 25 gauge pars plana vitrectomy revision coupled full thickness temporal hole and fluid-gas exchange. The main outcome measure was anatomic closure based on optical coherence tomography...
We investigated sera from elderly subjects with and without age-related macular degeneration (AMD) for presence of autoantibodies (AAbs) against human antigens characterized their identity.Sera were collected participants in the Age-Related Maculopathy Ancillary (ARMA) Study, a cross-sectional investigation ancillary to Health ABC enriched general population. The resulting sample (mean age: 79.2±3.9 years old) included early advanced AMD (n = 131) controls 231). Sera tested by Western blots...
To identify variables associated with primary anatomical outcome following vitrectomy and internal tamponade for rhegmatogenous retinal detachment (RD).A retrospective analysis of prospectively collected data, using a database RD treated tamponade. Collected data complied the RCOphth Retinal Detachment Dataset. The main measure was failure within six months surgery.There were 6377 vitrectomies. 869 eyes excluded, either because no recorded, or inadequate follow up, leaving 5508 operations...
A telerobotic platform developed in a collaboration between NASA-JPL and MicroDexterity Systems, Inc (MDS) is described this paper. The lightweight, compact 6 dof master-slave system precise to better than 10 microns can cover workspace greater 400 cubic centimeters. Current capabilities of the include manual position control with augmented shared modes automatic robot. Simulated force feedback on master device has been implemented plans are integrate reflection from slave end effector...
The Warburg effect, which reflects cancer cells' preference for aerobic glycolysis over glucose oxidation, contributes to tumor growth, progression and therapy resistance. restraint on pyruvate flux into mitochondrial oxidative metabolism in cells is part attributed the inhibition of dehydrogenase (PDH) complex. Src a prominent oncogenic non-receptor tyrosine kinase that promotes cell proliferation, invasion, metastasis resistance conventional targeted therapies. However, potential role...
In Brief Purpose: To provide a historical perspective on outcomes of surgery for infants with stage 5 retinopathy prematurity (ROP) as perfomed by single surgeon over 24-year period. Design: Retrospective observational cohort study. Methods: Setting: Clinical practice the Charles Retina Institute. Patients: The 601 ROP in at least one eye who were referred between 1977 and 2001. Charts reviewed demographic data postoperative anatomical visual acuity eyes that underwent surgery. Main Outcome...
To describe a series of patients with recurrent inferior retinal detachment complicated by proliferative vitreoretinopathy (PVR) treated pars plana vitrectomy and postoperative perfluoro-n-octane (PFO).Consecutive Grade C PVR were prospectively 25-gauge "medium-term" PFO for 2- to 3-week duration. All had subsequent removal in planned staged procedure.Forty-four eyes 44 included. Mean follow-up time was 30.71 ± 12.92 months. Successful reattachment achieved 86% (38/44). Reattachment rates...
To compare the efficacy and safety of conbercept ranibizumab when administered according to a treat-and-extend (TREX) protocol for treatment neovascular age-related macular degeneration (AMD) in China. Between May 2014 2015, 180 patients were treated 1 : ratio using or from four hospitals. Patients received either 0.5 mg intravitreal injections. Follow-up time was year based on TREX approach. Main outcomes measures include best-corrected visual acuity (BCVA), Early Treatment Diabetic...
<h3>Objective</h3> To assess pooled golimumab safety up to year 3 of rheumatoid arthritis (RA), psoriatic (PsA) and ankylosing spondylitis (AS) trials. <h3>Methods</h3> Golimumab 50 100 mg, administered subcutaneously (SC) every 4 weeks (q4wk), were assessed in patients with active RA (methotrexate-naïve, methotrexate-experienced anti-TNF (tumour necrosis factor)-experienced), PsA or AS, despite conventional therapy. Placebo control continued week (wk) 24 (wk 52, methotrexate-naïve), early...
A system was developed for transvitreal application of photocoagulation using a fiberoptic probe attached to portable xenon arc coagulator (endophotocoagulation, EPC). The is activated by footswitch, and the tip positioned near retina after performing pars plana vitrectomy. This technique can be used treat posterior retinal breaks, stop bleeding, coagulate neovascularization, apply scatter in certain diabetic eyes, some ciliary processes eyes with neovascular glaucoma, enlarge pupil iris...
Objective. To perform a survey of the American Society Retina Specialists (ASRS) regarding use vitreous cavity fluorinated gas as an adjunct to pars plana vitrectomy for retinal detachment or macular hole repair. Methods. A multiple-choice online questionnaire was administered members ASRS. Physician experience, preference vitrectomy, and categorical estimate observation blinding postoperative ischemic events were recorded. Results. 282 questionnaires completed. Mean years in vitreoretinal...