A5101595037- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- MicroRNA in disease regulation
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Cancer-related molecular mechanisms research
- Laser Applications in Dentistry and Medicine
- Dermatologic Treatments and Research
- Urinary Bladder and Prostate Research
- Retinal and Macular Surgery
- Wound Healing and Treatments
- Foot and Ankle Surgery
- Urological Disorders and Treatments
- Liver physiology and pathology
- Corneal surgery and disorders
- Orthopedic Surgery and Rehabilitation
- Urologic and reproductive health conditions
- Ocular Diseases and Behçet’s Syndrome
- Circular RNAs in diseases
- Fibroblast Growth Factor Research
- Psoriasis: Treatment and Pathogenesis
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
Affiliated Hospital of Southwest Medical University
2020-2025
Second Affiliated Hospital of Harbin Medical University
2011-2024
Soochow University
2023-2024
Harbin Medical University
2011-2024
Second Affiliated Hospital of Soochow University
2024
First Affiliated Hospital of Soochow University
2023
Ningbo First Hospital
2022-2023
Nanjing University of Chinese Medicine
2020
Central South University
2009-2018
Shanxi Provincial Cancer Hospital
2018
RORγt is necessary for the generation of TH17 cells but molecular mechanisms regulation are still not fully understood. We show that activation CD4+ T results in expression inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced cell differentiation without major effects on either TH1 or TH2 lineages, whereas endothelial NOS (eNOS) neuronal (nNOS) mutant showed comparable compared with wild-type control mice. The addition N6-(1-iminoethyl)-l-lysine dihydrochloride...
Activation of hepatic stellate cells (HSCs), which is regulated by multiple signal transduction pathways, the key event in liver fibrosis. Moreover, members these pathways are important targets for microRNAs (miRNAs). To better understand critical HSC activation, we performed comprehensive comparative bioinformatics analysis microarrays quiescent and activated HSCs. Changes miRNAs associated with activation status revealed that 13 were upregulated 22 downregulated miRNA. Furthermore,...
Thyroid cancer is one of the most prevalent endocrine tumors. The present study examined effects lncRNA HOXA cluster antisense RNA2 (HOXA-AS2) on progression papillary thyroid (PTC), and explored underlying molecular mechanisms.Quantitative real-time PCR was used to detect HOXA-AS2, miR-520c-3p S100 calcium-binding protein A4 (S100A4) expression. Furthermore, HOXA-AS2 silencing overexpression cell proliferation, migration, invasion were assessed in PTC vitro by CCK8 transwell assay....
Objectives This study aims to estimate the trends and disparities in worldwide burden for health of AMD, overall by age, sex, socio-demographic index (SDI), region, nation using prevalence years lived with disability (YLDs) from Global Burden Disease (GBD) 2019. Methods retrospective presents prevalent AMD cases YLDs 1990–2019, as well age-standardized rate (ASPR) YLD (ASYR) AMD. To measure changes over time, estimated annual percentage (EAPCs) rates (ASRs) were analyzed globally, then...
Abstract Stimulating bone formation potentially suggests therapeutics for orthopedic diseases including osteoporosis and osteoarthritis. Osteoblasts are key to remodeling because they act as the only bone-forming cells. miR-877-5p has a chondrocyte-improving function in osteoarthritis, but its effect on osteoblast differentiation is unknown. Here, miR-877-5p-mediated was studied. Real-time reverse transcriptase-polymerase chain reaction performed measure expression during osteogenic of...
This study is to evaluate the effectiveness of autologous platelet-rich fibrin (PRF) combined with ultra-pulsed carbon dioxide laser in treating cancellous bone-exposed wounds. A total 65 patients wounds were retrospectively analyzed selected. There 35 cases + PRF group (Laser group, L), and 30 routine surgical debridement (Routine R). Parameters compared included percentage wound healing at intervals 4, 8, 12, 16 days post-treatment, growth status granulation tissue, blood circulation, pain...
To compare the efficacy and safety of conbercept ranibizumab when administered according to a treat-and-extend (TREX) protocol for treatment neovascular age-related macular degeneration (AMD) in China. Between May 2014 2015, 180 patients were treated 1 : ratio using or from four hospitals. Patients received either 0.5 mg intravitreal injections. Follow-up time was year based on TREX approach. Main outcomes measures include best-corrected visual acuity (BCVA), Early Treatment Diabetic...
Polypoidal choroidal vasculopathy (PCV) is an irreversible retinal disease. Individuals with PCV exhibit diverse baseline characteristics, including systemic ocular traits, metabolic factor levels, and different responses to intravitreal anti-VEGF therapy. This study aims investigate the pathogenesis of by analyzing cytokine levels at within a cohort patients who treatment. We conducted retrospective analysis involving 80 eyes diagnosed PCV. Patients were categorized into two groups based on...
An E50K substitution in the transcription factor optineurin (OPTN) induces primary open‑angle glaucoma (POAG). To explore potential role of microRNAs (miRNAs) OPTN‑induced POAG, miRNA expression profiling was performed on retinal samples from OPTN (E50K) transgenic and wild‑type mice. The retinas were collected 30 mice, evaluated using a genome‑wide microarray. miRNAs that differentially expressed mice identified validated by reverse transcription‑quantitative polymerase chain reaction...
The present study was developed to explore whether microRNA (miR)-760 targets heparin-binding EGF-like growth factor (HBEGF) control cartilage extracellular matrix degradation in osteoarthritis. Both miR-760 and HBEGF expression levels were analysed human degenerative tissues interleukin (IL)-1β/tumour necrosis (TNF)-α-treated chondrocytes vitro. A series of knockdown overexpression assays then used gauge the functional importance OA, with qPCR western immunoblotting analyses. Bioinformatics...
The aims of the present study were to investigate effect E50K optineurin (OPTN) mutation on RGC‑5 cells and define role microRNA‑9 (miR‑9) in this system. Transfected used evaluate effects OPTN expression miR‑9 subsequent disruption cell apoptosis was analyzed using western blotting. results showed that associated with a marked reduction levels OPTN‑transfected cells. OPTN‑dependent reductions led increased transcriptional repressor, RE1‑silencing transcription factor decreased brain‑derived...
To compare the outcomes of viscoelastic substance injection with air filling in anterior chamber during foldable capsular vitreous body (FCVB) implant surgery patients severe retinal disease. Thirty eyes diseases were randomly divided into two groups. In group, 0.15-0.2 mL 1.7% sodium hyaluronate was injected after FCVB implantation; maintained by surgery. The treated examined a 24-week follow-up appointment. Data, including intraocular pressure (IOP), difference between preoperative and...
Background and Objectives Chronic wound repair is a major problem in treatment. Recently, several studies have suggested that carbon dioxide (CO 2 ) laser can be used to improve the healing of chronic wounds. The aim present study was preliminarily investigate efficacy debridement treating through comparison traditional instrument/surgical with ultrapulsed CO terms healing, infection control, blood perfusion. Study Design/Materials Methods Patients admitted Wound Repair Clinic at Affiliated...
It has previously been reported that propofol regulates the development of human osteosarcoma (OS). However, specific molecular mechanisms underlying effect on OS remain poorly understood. Therefore, aim present study was to explore effects U2OS cells and potential mechanism. The Cell Counting Kit-8 colony formation assays were performed assess cell viability proliferation. Furthermore, apoptosis assessed using TUNEL assay western blotting. Wound healing Transwell evaluate migration invasion...
To explore the impact of coronavirus disease 2019 (COVID-19) on stability patients with neovascular age-related macular degeneration (nAMD) receiving treat and extend (T&E) or pro re nata (PRN) treatment regimen to identify indicators that may predict nAMD. This is a retrospective study nAMD treated at Second Affiliated Hospital Harbin Medical University whose schedule was interrupted least once between 1 February 31 May 2020. The demographic clinical characteristics, including best...
BACKGROUND The aim of this study was to compare the effect 2 methods for treating toe-in gait in children (reverse-shoe wearing and orthopedic insoles) determine whether reverse-shoe results hallux valgus. MATERIAL AND METHODS Between July 2012 2014, 337 diagnosed with over years were recruited. For 139 children, parents selected use treatment (RS group) 198 insoles (OI group). There 98 RS group 167 OI who completed 12-month therapy follow-up. We excluded 28 failed complete study, 44 ceased...
Age-related macular degeneration (AMD) is a condition causing progressive central vision loss. Growing evidence suggests link between cellular senescence and AMD. However, the exact mechanism by which leads to AMD remains unclear. Employing machine learning, we established an diagnostic model. Through unsupervised clustering, two distinct subtypes were identified. GO, KEGG, GSVA analyses explored diverse biological functions associated with subtypes. By WGCNA, constructed coexpression...
Purpose: The purpose of this study was to compare the clinical efficacy foldable capsular vitreous body (FCVB) filled with either light or heavy silicone oil and incidence complications after their implantation for treatment severe ocular trauma oil-dependent eyes. Methods: FCVB (n = 16) 8) implanted in 24 patients. During 12-month follow-up period, intraocular pressure, final best-corrected visual acuity, retinal reattachment condition, position FCVB, were assessed. Results: All surgeries...
Male androgenetic alopecia (MAGA) has been one of the most common reasons for hair consultation, which affects more than half men under age 50. Recently, follicular unit extraction (FUE) megasession an attractive treatment option patients with severe AGA. However, compared transplant surgery by traditional FUE or transplantation (FUT), a lacks suitable surgical design solution Asian high-grade AGA patients. Therefore, we introduced novel principles into Asians.The goal was to investigate...