A5027983060- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Cerebral Venous Sinus Thrombosis
- Retinal and Macular Surgery
- Oral and gingival health research
- Angiogenesis and VEGF in Cancer
- Ocular Infections and Treatments
- Systemic Lupus Erythematosus Research
- Optical Coherence Tomography Applications
- Systemic Sclerosis and Related Diseases
- Drug-Induced Ocular Toxicity
- Oral Health Pathology and Treatment
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Periodontal Regeneration and Treatments
- Complement system in diseases
- Health Systems, Economic Evaluations, Quality of Life
- Blood groups and transfusion
- Photoreceptor and optogenetics research
- Protease and Inhibitor Mechanisms
Ospedale Policlinico San Martino
2016-2025
University of Genoa
2016-2025
International Flame Research Foundation
2011-2024
Fondazione Italiana Fegato
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015
Sapienza University of Rome
2009-2010
Instituto di Biofisica
2006
Massachusetts Eye and Ear Infirmary
1999-2000
Harvard University
1999-2000
Howard Hughes Medical Institute
2000
Mutations in rod opsin, the visual pigment protein of photoreceptors, account for ≈15% all inherited human retinal degenerations. However, physiological and molecular events underlying disease process are not well understood. One approach to this question has been study transgenic mice expressing opsin genes containing defined mutations. A caveat is that even overexpression normal leads photoreceptor cell degeneration. To overcome problem, we have reduced or eliminated endogenous content by...
Retinal photoreceptors use the heterotrimeric G protein transducin to couple rhodopsin a biochemical cascade that underlies electrical photoresponse. Several isoforms of each subunit are present in retina. Although rods and cones seem contain distinct subunits, it is not known whether phototransduction given cell type depends strictly on single form subunit. To approach this question, we have deleted gene for rod α-subunit mice. In hemizygous knockout mice, there was small reduction retinal...
To report the choroidal vascular flow area in eyes with central serous chorioretinopathy (CSC) compared healthy subjects and unaffected fellow using swept-source (SS) optical coherence tomography (OCT) angiography.Prospective case series of 19 consecutive patients affected by CSC, 15 20 10 subjects. Patients underwent SS-OCT angiography order to evaluate choriocapillaris (CC) deeper layers.The was higher CSC than control (53.4 ± 5.8% vs. 49.45 8.16%; P = 0.0001). Within choroid CC...
Several approaches have been investigated for treating wet age-related macular degeneration (w-AMD), diabetic edema (DME) and retinal vein occlusions (RVOs). The first-line treatment these exudative diseases consists of anti-vascular endothelial growth factor (VEGF) agents; however, the high burden percentage 'non responder' patients highlighted need other approaches. Increasing evidence has shown role angiopoietin/Tie (Ang/Tie) pathway in pathogenesis diseases; therefore, novel drugs...
Aims To explore prognostic multimarker models for progression to macular fibrosis (MF) over 24 months specific type 3 neovascularisation (T3 MNV). Methods This retrospective, exploratory, single-centre, cohort study comprised 65 eyes of 43 Caucasian patients with treatment naive T3 MNV, all a 24-month follow-up post anti-VEGF therapy using strict pro-re-nata (PRN) regimen. Data on demographic features, clinical findings, frequency intravitreal treatments and optical coherence tomography...
Purpose: To investigate by optical coherence tomography angiography (OCT-A) the choroidal vascular response to experimentally increased blood pressure in patients with central serous chorioretinopathy (CSCR). Methods: For this multicenter, observational, case-control study, we enrolled 35 an established diagnose of CSCR and 25 age-matched healthy controls. All subjects underwent a handgrip isometric exercise obtain elevation (BP). In resting phase during physical effort, macular...
Photobiomodulation (PBM) has become a promising approach for slowing the progression of early and intermediate dry age-related macular degeneration (dAMD) to advanced AMD. This technique uses light penetrate tissues activate molecules that influence biochemical reactions cellular metabolism. preliminary analysis is aimed at assessing safety, tolerability, short-term effectiveness EYE-LIGHT
To investigate machine learning methods, ranging from simpler interpretable techniques to complex (non-linear) "black-box" approaches, for automated diagnosis of Age-related Macular Degeneration (AMD).Data healthy subjects and patients diagnosed with AMD or other retinal diseases were collected during routine visits via an Electronic Health Record (EHR) system. Patients' attributes included demographics and, each eye, presence/absence major AMD-related clinical signs (soft drusen, pigment...
Abstract To investigate the correlations between finger microvascular morphology and function in patients with systemic sclerosis (SSc) status of ocular microcirculation, as detected by nailfold videocapillaroscopy (NVC), laser speckle contrast analysis (LASCA), optical coherence tomography angiography (OCTA). The enrollment included 32 SSc patients, classified according to 2013 ACR/EULAR criteria, 27 sex- age-matched healthy controls. participants underwent comprehensive rheumatological...
Purpose Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, particularly neovascular AMD (nAMD). This study aimed to investigate the real-world treatment patterns, effectiveness, and safety intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapies for anti-VEGF naïve nAMD patients in Italy. Methods RADIANCE retrospective, observational, multicenter cohort conducted at 13 clinical sites across The enrolled all consecutive with nAMD, any...
Oxidative stress is considered a common underlying mechanism in many retinal degenerative diseases and often associated with inflammation. The use of dietary supplements containing Saffron has beneficial effects ocular diseases, though the molecular mechanisms are still unclear. In this study, we investigated how can exert protective against oxidative damage pigment epithelial cells (ARPE-19) whether its combination Elderberry Melilotus may have additive effects. ARPE-19 were pretreated...
Purpose To evaluate the in vitro and vivo antimicrobial activity on microbial flora of eyelids conjunctiva new medicated wipes LENIVA bio, soaked with an antiseptic solution containing natural extracts from citrus fruits (Biosecur ® ), Aloe vera , Ruscus aculeatus . Methods The bio against bacteria fungi commonly found periocular area, including antibiotic-resistant strains, was measured by agar diffusion microdilution assays. swabs collected eyelid rim 20 patients (13 males, 7 females; mean...
Purpose To report one case of retinal pigment epithelium tear following intravitreal bevacizumab injection for neovascular age-related macular degeneration. Methods A 59-year-old patient presented with occult choroidal neovascularization associated a serous epithelial detachment secondary to The was treated an bevacizumab. Results developed 60 days the injection. Conclusions This describes development after Future studies should be performed evaluate which subtypes lesions are most...