A5045906857- Renal and related cancers
- Renal cell carcinoma treatment
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Hepatitis C virus research
- Infant Development and Preterm Care
- Childhood Cancer Survivors' Quality of Life
- Preterm Birth and Chorioamnionitis
- Meta-analysis and systematic reviews
- Respiratory Support and Mechanisms
- Nausea and vomiting management
- Neuroblastoma Research and Treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Vaccine Coverage and Hesitancy
- Statistical Methods in Clinical Trials
- Hepatitis Viruses Studies and Epidemiology
- Child and Adolescent Health
- Infant Nutrition and Health
- Cardiac Arrest and Resuscitation
- Drug-Induced Hepatotoxicity and Protection
- Acute Lymphoblastic Leukemia research
- Poisoning and overdose treatments
- Neonatal and fetal brain pathology
- Blood donation and transfusion practices
Odense University Hospital
2025
University of Southern Denmark
2025
Rigshospitalet
2015-2024
Copenhagen University Hospital
2012-2024
University College London
2016-2023
Great Ormond Street Hospital
2017-2023
University Hospital in Motol
2023
Hvidovre Hospital
2009-2022
Cochrane
2004-2022
University of Copenhagen
2008-2021
There is increasing awareness that meta-analyses require a sufficiently large information size to detect or reject an anticipated intervention effect. The required in meta-analysis may be calculated from priori effect suggested by trials with low-risk of bias.Information calculations need consider the total model variance control type I and II errors. Here, we derive adjusting factor for under any random-effects meta-analysis.We devise measure diversity (D2) meta-analysis, which relative...
Background Random error may cause misleading evidence in meta-analyses. The required number of participants a meta-analysis (i.e. information size) should be at least as large an adequately powered single trial. Trial sequential analysis (TSA) reduce risk random errors due to repetitive testing accumulating data by evaluating meta-analyses not reaching the size with monitoring boundaries. This is analogous boundaries Methods We selected apparently conclusive (P ≤ 0.05) Cochrane neonatal...
Please cite this paper as: Huusom L, Secher N, Pryds O, Whitfield K, Gluud C, Brok J. Antenatal magnesium sulphate may prevent cerebral palsy in preterm infants—but are we convinced? Evaluation of an apparently conclusive meta-analysis with trial sequential analysis. BJOG 2011;118:1–5.
Abstract Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder caused by somatic genetic alterations in hematopoietic precursor cells differentiating into CD1a+/CD207+ histiocytes. LCH clinical manifestation highly heterogeneous. BRAF and MAP2K1 mutations account for ∼80% of driver cells. However, their associations remain incompletely understood. Here, we present an international clinicogenomic study childhood LCH, investigating 377 patients genotyped at least BRAFV600E. MAPK...