A5020133322- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Antibiotics Pharmacokinetics and Efficacy
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- HIV Research and Treatment
- Pharmacological Effects and Toxicity Studies
- Vitamin D Research Studies
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
- Biochemical and Molecular Research
- Chronic Lymphocytic Leukemia Research
- Antifungal resistance and susceptibility
- Analytical Methods in Pharmaceuticals
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- Pharmaceutical studies and practices
- Drug Transport and Resistance Mechanisms
- Pesticide Residue Analysis and Safety
- Systemic Lupus Erythematosus Research
- Cannabis and Cannabinoid Research
- Antibiotic Resistance in Bacteria
- Fungal Infections and Studies
University of Turin
2016-2025
Ospedale Amedeo di Savoia
2016-2025
University of Florida
2018
Columbus Oncology and Hematology Associates
2018
GTx (United States)
2017
University of Pisa
2016
Laboratoire de Chimie
2015
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing risk infections; thus, we retrospectively investigated 25-hydroxyvitamin (25(OH)D) concentrations plasma obtained cohort Switzerland. In this cohort, significantly lower 25(OH)D levels (p = 0.004)...
Remdesivir has received significant attention for its potential application in the treatment of COVID-19, caused by SARS-CoV-2. already been tested Ebola virus disease and found to have activity against SARS MERS coronaviruses. The remdesivir core contains GS-441524, which interferes with RNA-dependent RNA polymerases alone. In non-human primates, following IV administration, is rapidly distributed into PBMCs converted within 2 h active nucleoside triphosphate form, while GS-441524...
Therapeutic drug monitoring (TDM) for antibiotic drugs represents a consolidated practice to optimize the effectiveness and limit toxicity of specific by guiding dosage adjustments. The comparison TDM results with drug-specific pharmacokinetic/pharmacodynamic (PK/PD) parameters, based on killing dynamics bacterial susceptibility, increases probability therapeutic success.The aim this study was analytical validation new UHPLC-MS/MS assay quantification 19 antibiotics divided in two different...
Abstract Objectives Knowledge of the exact concentration active compounds in galenic preparations is crucial to be able ensure their quality and properly administer prescribed dose. Currently, need for titration extracts still debated. Considering this, together with absence a standard preparation method, aim this study was evaluate cannabinoids concentrations variability olive oil extracts, interlot interlaboratory extraction yield composition. Methods Two hundred one (123 (61.2%) from...
Voriconazole therapeutic drug monitoring is not consistently recommended due to its high interpatient and intrapatient variability. Here, we aimed describe our experience with voriconazole for treatment prophylaxis of invasive fungal infections in paediatric patients. A fully validated high-performance liquid chromatography-mass spectrometry method was used quantify concentration plasma, at the end dosing interval. interindividual variability shown. We enrolled 237 children, 83 receiving...
Ritonavir-boosted atazanavir is a victim of drug-drug interaction with rifampicin, key component antitubercular treatment. In recent dose escalation clinical trial, we showed that increasing atazanavir/ritonavir to 300/100 mg b.i.d. compensates for reduced drug exposure in plasma due but the intracellular effects remained unexplored. This sub-study investigated penetration and dolutegravir into peripheral blood mononuclear cells (PBMC). Twenty-six healthy volunteers living HIV, virologically...
Aims Arterial hypertension is an important cardiovascular risk factor. A substantial proportion of patients show resistance to antihypertensive treatment but poor adherence medication regimens also a significant cause failure. In this context, therapeutic drug monitoring (TDM) could be useful. The objective study was assess in with resistant by TDM and identify parameters that predict nonadherence. Methods Liquid chromatography tandem mass spectrometry used quantify wide panel drugs human...
Summary Complete eradication of hepatitis B virus ( HBV ) is rarely achieved. Treatment options include currently available nucleos(t)ide analogues and pegylated interferon. The aim our exploratory study was to assess the effectiveness sequential therapy for chronic CHB vs current standard care. We evaluated an association with entecavir interferon alfa‐2a PEG ‐ IFN in 20 patients , high viremia genotypes A C E . Patients received alone 12 weeks, then lastly 36 weeks. results were compared...
Summary In this prospective study, we evaluated the effectiveness and tolerability of novel therapies against hepatitis C virus ( HCV ) in a cohort PWID enrolled at our centre from April 2015 to July 2016. analysis, total 174 patients were included: eleven (6.3%) treated with pegylated interferon PEG ‐ IFN ribavirin RBV containing regimens, 163 (93.7%) ‐free treatments. has been used 70 (40.2%); 59 (33.9%) opioid substitution therapy OST methadone or buprenorphine. Overall, sustained...
Background: Therapeutic drug monitoring (TDM) of the 2 calcineurin inhibitors (CNIs), tacrolimus (TAC) and cyclosporin A, has resulted in improvements management patients who have undergone solid organ transplantation. As a result TDM, acute rejection (AR) rates treatment-related toxicities been reduced. Irrespective, AR toxicity still occur transplantation, showing blood CNI concentrations within therapeutic range. Moreover, rate is no longer decreasing. Hence, smarter TDM approaches are...
We explored the role of SNPs within SLCO1B3, SLCO1B1, SLC22A6, ABCB1, ABCG2, SLCO3A1, CYP2C19, ABCC2, SLC22A1, ABCB11 and NR1I2 genes on voriconazole pharmacokinetics.233 pediatric patients were enrolled. Drug plasma Ctrough was measured by a HPLC-MS method. Allelic discrimination performed qualitative real-time PCR.SLCO1B3 rs4149117 c.334 GT/TT (p = 0.046), ABCG2 rs13120400 c.1194 + 928 CC 0.029) ABCC2 rs717620 c.-24 GA/AA 0.025) genotype groups significantly influenced Ctrough. ethnicity...
Dalbavancin (DBV) is a lipoglycopeptide approved for the treatment of Gram-positive infections skin and skin-associated structures (ABSSSIs). Currently, its off-label use at different dosages other deserves attention. This work aimed to study clinical effectiveness tolerability DBV in outpatients with ABSSSIs, osteoarticular (OA), or infections, treated either one two 1500 mg doses dalbavancin, scheduled periods. A liquid chromatography–tandem mass spectrometry method was used measure total...
In HBV-infected patients, the vitamin D deficiency has been related to chronic liver diseases, progression of hepatic fibrosis and poor response treatment. The CYP27B1 gene, which encodes 1-α-hidroxylase involved in 1,25-dihydroxyvitamin synthesis, was recently associated type-1 diabetes, autoimmune disorders treatment HCV. Then, we aimed investigate role polymorphisms HBV with PEG-IFN. We retrospectively enrolled 190 patients hepatitis B HBeAg negative treated for 48 weeks PEG-IFN α-2a....