A5057332428- Hormonal and reproductive studies
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Adrenal Hormones and Disorders
- Biosimilars and Bioanalytical Methods
- HIV/AIDS drug development and treatment
- Pharmacological Effects and Assays
- Muscle metabolism and nutrition
- Metabolomics and Mass Spectrometry Studies
- Pesticide Residue Analysis and Safety
- Organ Transplantation Techniques and Outcomes
- Hormonal Regulation and Hypertension
- Pharmacological Effects and Toxicity Studies
- Neurological Complications and Syndromes
- Adrenal and Paraganglionic Tumors
- Genomics and Rare Diseases
- Estrogen and related hormone effects
- Supramolecular Chemistry and Complexes
- Immunotoxicology and immune responses
- Effects and risks of endocrine disrupting chemicals
- Methemoglobinemia and Tumor Lysis Syndrome
- Liver Disease and Transplantation
- Potassium and Related Disorders
- Renal function and acid-base balance
- Phytoestrogen effects and research
University of Turin
1996-2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2014-2023
Laboratoire de Biochimie
2022
Azienda Ospedaliero Universitaria San Giovanni Battista
2009
Volumetric Absorptive Microsampling (VAMS) is emerging as a valuable technique in the collection of dried biological specimens, offering potential alternative to traditional sampling methods. The objective this study was assess suitability 30 μL VAMS for measurement endogenous steroid hormones.
Abstract Context Adrenal venous sampling (AVS) is the gold standard procedure for subtype diagnosis in patients with primary aldosteronism (PA). Cortisol usually adopted normalization of aldosterone levels peripheral and adrenal samples. However, asymmetrical cortisol secretion can potentially affect lateralization index, leading to misdiagnosis. Objective We aimed assess prevalence undergoing AVS whether variations vein might influence interpretations. then evaluated use metanephrines...
Background and Aim: Asymmetric dimethylarginine (ADMA) symmetric (SDMA) have been proposed as mediators of endothelial dysfunction.In this study, we aimed to investigate the diagnostic prognostic role ADMA SDMA in acute cerebrovascular disease. Methods Results:A prospective case-control study was performed, enrolling 48 patients affected by ischemic stroke with no cardioembolic origin, 20 TIA, 40 subjects at high cardiovascular risk 68 healthy subjects.ADMA levels were significantly lower...
Tacrolimus (TAC, FK-506) and everolimus (EVE, RAD001) are immunosuppressors used to treat pediatric patients undergoing liver transplantation. Their hematic TDM by liquid chromatography became standard practice. However, it does not always reflect concentrations at their active site. Our aim was develop validate a new method for the simultaneous TAC EVE quantification into target cells: peripheral blood mononuclear cells (PBMCs). Peripheral were collected using cell preparation tubes; number...
The aim of the present study was to investigate influence cytochrome P450 (CYP) 3A4/5 genotype in paediatric liver transplant recipients and donors, contribution age gender tacrolimus disposition on first day after transplantation.The CYP3A4/5 donors blood trough concentrations (C0 ) concentration/weight-adjusted dose ratio 1 evaluated 67 liver-transplanted children: 33 boys 34 girls, mean 4.5 years.Donor CYP3A5 appears be significantly associated with transplantation (P < 0.0002). Other...
The simultaneous measurement of dexamethasone and cortisol has proven the ability to increase diagnostic performance overnight dexamethasone-suppression test. Furthermore, therapeutic drug monitoring administered corticosteroid drugs could represent a crucial tool for investigating unexpected variations steroid hormones' circulating levels. In this work, an LC-MS/MS method quantification cortisol, cortisone, six additional exogenous corticosteroids in serum/plasma matrix was developed...
Tacrolimus (TAC) is a first-choice immunosuppressant for solid organ transplantation, characterized by high potential drug-drug interactions, significant inter- and intra-patient variability, narrow therapeutic index. Therapeutic drug monitoring (TDM) of TAC concentrations in whole blood (WB) capable reducing the incidence adverse events. Since acts within lymphocytes, its peripheral mononuclear cells (PBMC) may represent valid future alternative TDM. Nevertheless, intracellular their...
Total Value of Ownership (TVO) and Overall Equipment Effectiveness (OEE) analysis are novel tools capable monitoring analyzing industrial processes by assessing the efficiency entire instrumental equipment calculating instrument capacity utilization. Such integrated analysis, measuring quality indicators testing process, could also provide new perspectives methodologies for workflow organization clinical laboratories. In this study, TVO OEE were employed evaluation two different...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Biochemical confirmation of ovulation typically involves measuring serum progesterone levels during the mid‐luteal phase. Alternatively, this information could be obtained by monitoring urinary excretion conjugated metabolites ovarian steroids such as pregnanediol 3‐glucuronide (PDG) using immunoassay techniques that have methodological limitations. The aim present study was to develop a mass spectrometry (MS)‐based method for rapid and accurate measurement PDG in spot urine...
From an analytical point of view, the difference between medical cannabis and light is in percentage pharmacologically active cannabinoids.The Italian FM 2 product contains about 6% Δ 9 -tetrahydrocannabinol (THC) 8% cannabidiol (CBD).Conversely, THC generally less than 0.2% or some specific cases 0.4% while CBD can range from 2% to 40%.The use these two products completely different.Medical a symptomatic treatment mainly used for neuropathic pain multiple sclerosis as well peripheral pain,...