A5027419566- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Urological Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Abdominal Surgery and Complications
- Appendicitis Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic and Kidney Cyst Diseases
- Liver Disease Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Childhood Cancer Survivors' Quality of Life
- Abdominal Trauma and Injuries
- Neutropenia and Cancer Infections
- Urinary and Genital Oncology Studies
- Neurological Complications and Syndromes
- Cancer Mechanisms and Therapy
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2020-2024
University of Turin
2010-2023
May Institute
2022
Fondazione Ricerca Molinette
2021
Ospedale San Luigi Gonzaga
2013
Princess Alexandra Hospital
1992
Graphical Abstract
We aimed to analyze outcomes of early and delayed laparoscopic cholecystectomy in the elderly our General Surgery Division. analyzed 114 LC performed from 1st January 2008 31st December 2012 division: 67 were for gallbladder stones 47 acute cholecystitis. Comparison between Ordinary Emergency groups showed that drain placement post-operative hospital stay significatively different. There no significative differences Early Laparoscopic Cholecystectomy (E-ELC) Delayed (D-ELC). weren't any...
Gallbladder carcinoma is a rare high malignancy neoplasm. The incidence of intra or post-operative incidental gallbladder diagnosis estimated between 0,2 and 2,8%. Primary aim our study to evaluate carcinoma's in experience. We retrospectively reviewed Surgery Division's experience about the totality laparoscopic cholecystectomies with histological evidence cancer. evaluated patients' characteristics, surgical related variables, response, surgivcal radicalization characteristics outcome. In...
Pediatric liver transplantation is a challenging surgical procedure requiring complex post-transplant patient management. Liver in children should ensure long-term survival and good health-related quality of life (HR-QOL), but data the literature are conflicting. With aim investigating psychosocial outcomes patients transplanted during childhood, we identified 40 with ≥ 20-year follow-up after regularly followed up at our Institution. Clinical charts were reviewed to retrieve patients' data....
Aim of this study is to present our standardized laparoscopic transabdominal preperitoneal hernia repair (TAPP) technique, and experience in the elderly as far concerns preoperative postoperative variables. We described TAPP technique according with Stuttgart [1], we evalutated team's inguinal (> 65 yrs) young patients (< yrs). retrospectively reviewed Surgery Division's about TAPP; included 185 patients. The sample was subdivided two groups: Group years patients) TAPPe patients). composed...
Laparoscopic appendectomy for acute appendicitis is one of the most common surgical procedures performed in world. We aimed to compare laparoscopic and open elderly our experience. a retrospective review patients who underwent from 1st January 2006 31st July 2012. analyzed 39 appendectomies patients: 20 were using technique (Group O) 19 L). In analysis intraoperative variables there was no statistically significant difference. this study difference also peri-operative variables. safe...
Laparoscopic approach for wound defects is a procedure that aims to reduce surgical aggressiveness against the abdominal wall by using minimal incisions and dedicated instruments. We report our experience about clinical outcome of elderly patients undergoing laparoscopic repair incisional hernias (Group I) primary inguinal II) from June 2007 September 2012. analyzed preoperative postoperative data in elderly. In there was no significant difference between normalweight overweight patients....
The impact of graft fibrosis and inflammation on the natural history pediatric liver transplants is still debated. Our objectives were to evaluate evolution posttransplant over time at protocol biopsies (PLBs), risk factors for fibrosis, presence donor-specific antibodies (DSAs), and/or their correlation with recipient factors.A single-center, retrospective (2000-2019) cross-sectional study transplant recipients who had least 1 PLB, followed by a longitudinal evaluation in those 2 PLBs, was...
Tacrolimus (TAC) is a first-choice immunosuppressant for solid organ transplantation, characterized by high potential drug-drug interactions, significant inter- and intra-patient variability, narrow therapeutic index. Therapeutic drug monitoring (TDM) of TAC concentrations in whole blood (WB) capable reducing the incidence adverse events. Since acts within lymphocytes, its peripheral mononuclear cells (PBMC) may represent valid future alternative TDM. Nevertheless, intracellular their...
Abstract Tacrolimus (TAC) pharmacokinetics is influenced by the donor CYP3A5 genotype and age of pediatric liver recipients. However, an optimization a genotype-based algorithm for determining TAC starting needed to earlier achieve stable target levels. As graft itself responsible its metabolism, Graft-to-Recipient Weight Ratio (GRWR) might play role in dose requirements. A single-center study was carried out cohort 49 recipients analyse impact patient characteristics on during first 15...
Rare diseases are chronic and life-threatening disorders affecting < 1 person every 2,000. For most of them, clinical symptoms signs can be observed at birth or childhood. Approximately 80% all rare have a genetic background them monogenic conditions. In addition, while the majority these is still incurable, early diagnosis specific treatment improve patients' quality life. Transplantation among therapeutic options represents definitive for end-stage organ failure, both in children adults....
Background Hepatocyte nuclear factor 1B (HNF1B ) is a member of the homeodomain-containing family transcription factors located on 17q12. HNF1B deficiency associated with clinical syndrome (kidney and urogenital malformations, maturity-onset diabetes young, exocrine pancreatic insufficiency) to an underdiagnosed liver involvement. Differently from HNF1A , correlation between hepatocellular carcinoma (HCC) germline has been poorly evaluated. Case report Here, we novel case syndromic...
Background Tuberous sclerosis complex (TSC) is a rare multisystemic disorder. This genetically determined disease characterized by highly variable clinical expression, including epilepsy as common feature. Seizures can also occur manifestation of symptomatic hypoglycemia. The latter could be caused an insulinoma, whose association to TSC has already been debated. In TSC-associated tumors, dysregulation the mTOR pathway believed present, leading significant impacts on cellular metabolism,...
EDITORIAL COMMENT : We accepted this case report not just because of its rare anecdotal interest but also it has a useful discussion which will help readers to diagnose urethral diverticulum when presents, usually in patient with recurrent urinary tract infection.
ABSTRACT Objectives: The aims of the study was to expand pediatric experience on hepatitis‐B virus (HBV) reactivation, a known complication in patients with hematologic malignancies or immunosuppression. Methods: Retrospective appraisal HBV therapy/prophylaxis immunocompromised children, studied from April 2006 March 2020. Results: Eighteen HBV‐positive patients, 5 girls, median age 11.1 (4.1‐‐17.9) years were included. Seventeen 18 immunosuppressed at HBV‐infection diagnosis. high risk 1...
Hepatocellular adenomas (HAs) are tumors that can develop under different conditions, including in patients harboring a germline mutation HNF1A. However, little is known about the pathogenesis of such disease. This work aims to better define what mechanisms lie development this condition. Six HAs were sampled from liver 17-year-old male affected by diabetes and multiple hepatic adenomatosis heterozygous pathogenic variant c.815G>A, p.(Arg272His) HNF1A, which has dominant negative effect....
Combined liver-kidney transplantation is a therapeutic option for children affected by type 1 primary hyperoxaluria. Persistently high plasma oxalate levels may lead to kidney graft failure. It debated whether pre-emptive liver transplantation, followed might be better strategy reduce loss. Our experience of 6 pediatric combined transplants hyperoxaluria in recipients was retrospectively analyzed. Plasma were monitored before and after transplantation. All the on hemodialysis at Median [IQR]...
Unavailability of the iliac-caval system due to thrombosis or aberrant anatomy may preclude kidney transplantation (KT) in small infants, exposing them complications long-term dialysis. A tailored approach enable KT also these difficult patients.We report cases 2 pediatric patients with a history hemodialysis, previously failed KT, pending exhaustion vascular accesses for dialysis, and unsuitability axis as site KT. Both were successfully managed by using splenic vessels source arterial...