A5071876116- Hemoglobinopathies and Related Disorders
- Diabetes Management and Research
- Iron Metabolism and Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Clinical Laboratory Practices and Quality Control
- Erythrocyte Function and Pathophysiology
- Neonatal Health and Biochemistry
- Hemoglobin structure and function
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Blood groups and transfusion
- Electrochemical sensors and biosensors
- Cholinesterase and Neurodegenerative Diseases
- Microfluidic and Capillary Electrophoresis Applications
- Mass Spectrometry Techniques and Applications
- Pesticide Exposure and Toxicity
- Metabolism and Genetic Disorders
- Diet, Metabolism, and Disease
- Analytical Methods in Pharmaceuticals
- Renal function and acid-base balance
- Statistical Methods in Clinical Trials
University of Milan
2015-2024
Istituto per le Tecnologie Didattiche
1992-2023
Institute of Biomedical Technologies
1996-2023
National Research Council
2020-2023
University of Calabria
2023
World Health Organization Regional Office for the Eastern Mediterranean
2015-2019
Sociedade Brasileira de Psicologia
2018
Newmarket Equine Hospital
2017
Venice International University
2003-2015
Japan Research Institute
2015
Abstract Background: The national programs for the harmonization of hemoglobin (Hb)A1c measurements in US [National Glycohemoglobin Standardization Program (NGSP)], Japan [Japanese Diabetes Society (JDS)/Japanese Clinical Chemistry (JSCC)], and Sweden are based on different designated comparison methods (DCMs). future basis international standardization will be reference system developed by IFCC Working Group HbA1c Standardization. aim present study was to determine relationships between...
HbA 1c is the stable glucose adduct to N-terminal group of β-chain 0 . The measurement in human blood most important for long-term control glycaemic state diabetic patients. Because there was no internationally agreed reference method IFCC Working Group on Standardization developed a which here described. In first step haemoglobin cleaved into peptides by enzyme endoproteinase Glu-C, and second glycated non-glycated hexapeptides obtained are separated quantified HPLC electrospray ionisation...
The IFCC Reference Measurement System for hemoglobin (Hb)A(1c) (IFCC-RM) has been developed within the framework of metrologic traceability and is embedded in a network 14 reference laboratories. This paper describes outcome 12 intercomparison studies (periodic evaluations to control essential elements IFCC-RM).Each study included: unknown samples (to test individual laboratories); known (controls); recently manufactured calibrators check calculated assigned value); stored stability)...
The reference intervals for hemoglobin A1c (Hb A1c) in pregnant women without diabetes are not well defined, and few examples of established by networks different laboratories available.Five Italian Diabetic Care Units were involved the study. Data collected from 445 diabetes, selected on basis glucose challenge test results, 384 nonpregnant control women. Hb measurements performed with HPLC systems aligned to Diabetes Control Complications Trial. Plasma also locally. Both harmonized running...
Summary Although DNA analysis is needed for characterization of the mutations that cause β‐thalassaemia, measurement Hb A 2 essential routine identification people who are carriers β‐thalassaemia. The methods quantitating described together with pitfalls in undertaking these laboratory tests particular emphasis on automated high‐performance liquid chromatography and capillary electrophoresis.
Summary Measurement of the Haemoglobin F in red cell haemolysates is important diagnosis δβ thalassaemia, hereditary persistence fetal haemoglobin (HPFH) and management sickle disease. The distribution Hb cells useful HPFH assessment feto‐maternal haemorrhage. methods quantifying are described together with pitfalls undertaking these laboratory tests particular emphasis on automated high‐performance liquid chromatography capillary electrophoresis.
Abstract BACKGROUND A major objective of the IFCC Committee on Education and Use Biomarkers in Diabetes is to generate awareness improvement HbA1c assays through evaluation performance by countries manufacturers. METHODS Fresh whole blood lyophilized hemolysate specimens manufactured from same pool were used 17 external quality assessment organizers evaluate analytical 2166 laboratories. Results evaluated per country, manufacturer, manufacturer country combined according criteria model for...
Crocodilian hemoglobin has a high intrinsic oxygen affinity but does not react with those organic phosphate esters that normally control the of blood in higher vertebrates.Instead, its is greatly lowered by CO,.The present study was undertaken to determine nature COZ binding crocodilian species, Caiman, both qualitatively and quantitatively.The following parameters were measured: (a) carbamino compounds deoxy-and oxyhemoglobin, (b) effect (at constant pH) on Caiman hemoglobin, (c) total CO,...
Background: Point-of-care (POC) testing devices for monitoring glucose and ketones can play a key role in the management of dysglycemia hospitalized diabetes patients. The accuracy be influenced by biochemical changes that commonly occur critically ill hospital patients medication prescribed. Little is known about influence these factors on ketone POC measurements. aim this study was to assess analytical performance whole-blood meters extent interference design results. Methods: StatStrip...