A5033319493- Pediatric Hepatobiliary Diseases and Treatments
- Sarcoma Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Tumors and Oncological Cases
- Intestinal Malrotation and Obstruction Disorders
- Soft tissue tumor case studies
- Liver Disease Diagnosis and Treatment
- Oral health in cancer treatment
- Liver Disease and Transplantation
- Lymphoma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Cancer Studies
- Esophageal and GI Pathology
- Advanced Radiotherapy Techniques
- Osteomyelitis and Bone Disorders Research
- Dermatological and COVID-19 studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Hernia repair and management
- Renal and related cancers
- Congenital Diaphragmatic Hernia Studies
- Redox biology and oxidative stress
- Vascular Malformations and Hemangiomas
- Autoimmune and Inflammatory Disorders
- Genetic and rare skin diseases.
- Chromatin Remodeling and Cancer
Royal Manchester Children's Hospital
2011-2025
University of California, San Francisco
2024
National Health Service
2023
Maimonides Medical Center
2019-2023
Manchester University NHS Foundation Trust
2020-2022
Manchester Academic Health Science Centre
2015-2021
University of California, Davis
2020
Children's Hospital of Philadelphia
2016
University of Toronto
2011-2013
Great Ormond Street Hospital
2011
Biliary atresia (BA) is a progressive fibroinflammatory cholangiopathy affecting the bile ducts of neonates. Although BA leading indication for pediatric liver transplantation, etiology remains elusive. Adducin 3 (ADD3) and X-prolyl aminopeptidase 1 (XPNPEP1) are 2 genes previously identified in genome-wide association studies as potential susceptibility genes. Using zebrafish, we investigated importance ADD3 XPNPEP1 functional studies.To determine whether loss either gene leads to biliary...
Cutaneous involvement is a rare manifestation of tuberculosis (TB). The correct diagnosis often significantly delayed because cutaneous TB not routinely considered in the differential or investigations fail to reveal presence Mycobacterium tuberculosis. clinical features are diverse, and result from exogenous endogenous spread M. immune-mediated mechanisms. recognition important, as frequently overlooked resulting treatment.
ABSTRACT Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal reduce subsequent recurrences. However, differences lymph node strategies, definitions, treatment protocols between Children's Oncology Group (COG), European paediatric Soft tissue Study (E p SSG), Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim establish internationally recognized...
Background: Parenteral nutrition (PN) is a common supportive care therapy in patients undergoing hematopoietic stem cell transplantation (HSCT). Inadequate oral dietary intake may necessitate prolonged courses of PN, which have been associated with metabolic, infectious, and hepatobiliary complications. The objective this study was to identify demographic, clinical, factors the resumption following HSCT. Methods: This an observational cohort 37 children allogeneic Repeated‐measures...
Abstract Introduction: Neonates are obligate nasal breathers, and obstruction may have serious implications. We present an extremely rare cause of neonatal obstruction, its management. Case report: An eight-day-old neonate was referred for upper airway obstruction. Initial investigations had identified no obvious cause. Rigid endoscopy revealed a large, cystic lesion appearing to arise from the roof posterior space. Computed tomography magnetic resonance imaging indicated basal cephalocoele...
Inflammatory bowel disease (IBD) pathogenesis is thought to be induced by a mix of genetic susceptibility, microbial populations, and immune triggers such as infections. Severe acute respiratory syndrome coronavirus 2 (SARS-nCoV2) may have increased capacity generate autoimmune evidenced known spikes in diseases type 1 diabetes mellitus. Public health interventions like masking closures additionally created remarkable drops typical viral infections, with shifts influenza-like illness...
Thioredoxin expression within the reproductive tissues of female mouse was analysed during oestrous cycle stages dioestrus, oestrus and metoestrus by Western blot analyses immunocytochemistry. From thioredoxin found to be increased in compared dioestrus metoestrus. Localisation organs has shown that is specific for distinct areas organs. These are stratified squamous epithelium vagina, simple columnar uterine glands uterus, ciliated oviduct, corpus lutea, interstitial cells secondary...
Birth-related acute profound hypoxic-ischaemic brain injury has specific patterns of damage including the paracentral lobules.To test hypothesis that there is anatomically coherent regional volume loss corpus callosum as a result this hemispheric abnormality.Study subjects included 13 children with proven and developmental delay but no abnormalities. A computerised system divided into 100 segments, measuring each width. Principal component analysis grouped widths contiguous anatomical...
Abstract Background The aim of this study was to assess the clinical impact indeterminate pulmonary nodules (no more than four less 5 mm or one nodule measuring between and 10 by computed tomography [CT]) in children adolescents with adult‐type non‐rhabdomyosarcoma soft tissue sarcoma (NRSTS) at diagnosis. Methods Patients NRSTS treated 11 centers as part European paediatric Soft Tissue Sarcoma Study Group (EpSSG) were retrospectively assessed. Local radiologists, blinded information except...
Background Nephroblastomatosis is a recognised precursor for the development of Wilms tumour (WT), most common childhood renal tumour. While majority WT sporadic in origin, germline intragenic mutations predisposition genes such as WT1 , REST and TRIM28 have been described apparently isolated (non-familial) WT. Despite constitutional CNVs being well-studied cause developmental disorders, their role cancer less well defined, so that interpretation risks associated with specific can be...
Many studies on pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory coronavirus 2 (PIMS-TS) have described abdominal findings as part of involvement, limited descriptions imaging specific to PIMS-TS.To perform a detailed evaluation in children PIMS-TS.We performed single-center retrospective study admitted our institution between April 2020 and January 2021 who fulfilled Royal College Paediatrics Child Health criteria for PIMS-TS had...
ABSTRACT: Atypical teratoid/rhabdoid tumor (AT/RT) is a rare central nervous system (CNS) diagnosed primarily in infants and usually portends poor prognosis. Despite being the most common embryonal children less than 1 year old, diagnosis difficult to make based on clinical findings or imaging alone. A complete of AT/RT requires identification loss integrase interactor (INI1) protein SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin, subfamily b, member (SMARCB1) gene,...