A5080272123- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Surgical site infection prevention
- Testicular diseases and treatments
- Soft tissue tumor case studies
- Bone Tumor Diagnosis and Treatments
- Lymphoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Pediatric Urology and Nephrology Studies
- Chromatin Remodeling and Cancer
- Organ Transplantation Techniques and Outcomes
- Renal cell carcinoma treatment
- Cardiac tumors and thrombi
- Cardiac Structural Anomalies and Repair
- Renal and related cancers
- Urologic and reproductive health conditions
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
Princess Máxima Center
2020-2025
Máxima Medisch Centrum
2024
Radboud University Nijmegen
2024
Erasmus MC - Sophia Children’s Hospital
2016
Vrije Universiteit Amsterdam
2006
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co-primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported.The RMS2005 study included two phase III randomized high-risk (HR) and observational low (LR), standard (SR), very...
Appropriate imaging is essential in the treatment of children and adolescents with rhabdomyosarcoma. For adequate stratification optimal individualised local utilising surgery radiotherapy, high-quality crucial. The paediatric radiologist, therefore, an member multi-disciplinary team providing clinical care research. This manuscript presents European rhabdomyosarcoma guideline, based on recently developed guideline Paediatric Soft Tissue Sarcoma Study Group (EpSSG) Imaging Committee. was...
Rhabdomyosarcoma, although rare, is the most frequent soft tissue sarcoma in children and adolescents. It can present as a mass at nearly any site body, with common presentations head neck, genitourinary tract extremities. The optimal diagnostic approach management of rhabdomyosarcoma require multidisciplinary team multimodal treatment, including chemotherapy local therapy. Survival has improved over last decades; however, further improvement essential current 5-year overall survival ranging...
To assess the outcomes of pediatric patients with undifferentiated embryonal sarcoma liver (UESL) and treatment including at least surgery systemic chemotherapy.This study included aged up to 21 years a pathological diagnosis UESL prospectively enrolled from 1995 2016 in three European trials focusing on effects surgical margins, preoperative chemotherapy, use radiotherapy (RT), chemotherapy.Out 65 median age 8.7 (0.6-20.8), 15 had T2 tumors, one lymph node spread, 14 were Intergroup...
ABSTRACT Accurate staging of nodal involvement in pediatric sarcoma patients is important to determine correct systemic and local therapy, with the goal reduce subsequent recurrences. However, differences lymph node strategies, definitions, treatment protocols between Children's Oncology Group (COG), European paediatric Soft tissue Study (E p SSG), Cooperative Weichteilsarkom Studiengruppe (CWS) complicate comparisons. In this article, we aim establish internationally recognized...
Rhabdomyosarcoma of the extremities present with two main challenges: correct evaluation initial regional nodal involvement and define adequate local treatment.Pediatric patients localized rhabdomyosarcoma extremity included in EpSSG-RMS2005 study between 2005 2014 were evaluated for staging, treatment, survival. The outcome was compared to preceding European SIOP-MMT studies.Of 162 included, histology unfavorable 113 (70%), 124 (77%) younger than 10 years, 128 (79%) IRS III, 47 (29%)...
The treatment of extremity rhabdomyosarcoma remains a challenge due to several adverse prognostic factors frequently associated with this tumor site. International Soft-Tissue Sarcoma Database Consortium (INSTRuCT) is collaboration the Children's Oncology Group Committee, European Pediatric Study Group, and Cooperative Weichteilsarkom Studiengruppe. INSTRuCT surgical committee developed an internationally applicable consensus opinion document for rhabdomyosarcoma. This addresses management,...
Abstract Background/objectives Rhabdomyosarcoma of the perianal/perineal region (PRMS) is rare, with poor survival and limited understanding functional consequences treatment. Design/methods International Society Pediatric Oncology (SIOP) malignant mesenchymal tumor (MMT) 95, Italian RMS 96, European paediatric Soft tissue sarcoma Study Group (EpSSG) 2005 studies were interrogated to identify factors that impact survival; in 2005, outcomes analyzed. Results Fifty patients (nonmetastatic)...
Abstract Background Treatment of children and adolescents with alveolar rhabdomyosarcoma (ARMS) regional nodal involvement (N1) have been approached differently by North American European cooperative groups. In order to define a better therapeutic strategy, we analyzed two studies conducted between 2005 2016 the paediatric Soft tissue sarcoma Study Group (EpSSG) Children's Oncology (COG). Methods We retrospectively identified patients ARMS N1 enrolled in either EpSSG RMS2005 or COG ARST0531....
Abstract Background Paratesticular rhabdomyosarcoma (PT RMS) is rare compared to benign scrotal pathology. Inappropriate first surgery (InFS) required supplementary treatment maintain excellent outcomes. Initial staging of regional lymph nodes important. The aim this study was determine what extent the quality locoregional approach impacted on patient morbidity and survival. Design/methods Analysis performed all nonmetastatic PT RMS patients enrolled in European paediatric Soft tissue...
In this retrospective single center cohort study, we report the surgical outcomes of nephron-sparing surgery (NSS) for Wilms' tumor (WT) patients since centralization pediatric oncology care in Netherlands, and implementation technological advancements. Therewith describe influence experience innovations type surgery. We retrospectively assessed all NSS procedures from January 1st 2015 until 2024 who underwent a renal at Princess Máxima Center Pediatric Oncology. Data were gathered on...
Nodal staging accuracy is important in the prognosis and selection of patients for chemotherapy. This prospective study aims to assess feasibility sentinel lymph node procedure (SNP) using radiocolloid blue dye colon carcinoma.In 56 patients, lymphatic mapping was accomplished by means intraoperatively injecting patent nanocoll subserosally around tumour. Sentinel nodes (SNs) were harvested ex-vivo. Nodes stained with H&E. If interpreted as negative metastatic tumour, serial sectioning...
Summary Rhabdomyosarcomas (RMS) are mesenchyme-derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for high-risk patients. Discovery of new therapies would benefit from additional preclinical models. Here we describe generation collection pediatric RMS tumor organoid (tumoroid) models comprising all major subtypes. For aggressive tumors, tumoroid can often be established within four to eight weeks, indicating feasibility...
Background: Treatment of children and adolescents with alveolar rhabdomyosarcoma (ARMS) regional nodal involvement (N1) have been approached differently by North American European cooperative groups. In order to define the better therapeutic strategy, we analyzed two studies conducted between 2005 2016 paediatric Soft tissue sarcoma Study Group (EpSSG) Children’s Oncology (COG). Methods: We retrospectively identified patients ARMS N1 enrolled in either EpSSG RMS2005 or COG ARST0531....
Background: Regional lymph node disease (N1) is a component of the risk-based treatment stratification in rhabdomyosarcoma (RMS). The purpose this study was to determine contribution nodal prognosis for patients with non-metastatic embryonal RMS (ERMS) and analyze their outcome by received. Patients methods: Between 2005 2016, 1294 children ERMS were enrolled EpSSG protocol, 143 N1. Treatment comprised 9 cycles ifosfamide, vincristine actinomycin D. Some also received doxorubicin and/or...
Background To assess the outcomes of pediatric patients with Undifferentiated Embryonal Sarcoma Liver (UESL) and treatment including at least surgery systemic chemotherapy. Methods This study included aged up to 21 years a pathological diagnosis UESL prospectively enrolled from 1995 2016 in three european trials focusing on effects surgical margins, preoperative chemotherapy, use radiotherapy (RT) Results Out 65 median age 8.7 (0.6-20.8), 15 had T2 tumors, 1 lymph node spread, 14 were...