A5058252063- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Surgical site infection prevention
- Management of metastatic bone disease
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Vascular Tumors and Angiosarcomas
- Orthopedic Infections and Treatments
- Cardiac tumors and thrombi
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Testicular diseases and treatments
- Musculoskeletal synovial abnormalities and treatments
- Soft tissue tumors and treatment
- Cancer Genomics and Diagnostics
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Spine and Intervertebral Disc Pathology
- Total Knee Arthroplasty Outcomes
- Shoulder and Clavicle Injuries
- Hematopoietic Stem Cell Transplantation
- Pelvic and Acetabular Injuries
- Acute Lymphoblastic Leukemia research
Moffitt Cancer Center
2016-2025
University of South Florida
2004-2024
University of Missouri
2024
Florida College
2010-2022
Stryker (United States)
2021
The Ohio State University Wexner Medical Center
2021
Johns Hopkins All Children's Hospital
2020
Johns Hopkins University
2020
Children's Hospital of Philadelphia
2012-2016
University of Pennsylvania
2012
Long-term survival for all patients with osteosarcoma using current aggressive adjuvant chemotherapy and surgical resection is between 60% 70%. In who present nonmetastatic, high-grade extremity of bone, limb salvage surgery favored, when appropriate, over amputation to preserve the limb, because may lead a superior quality life compared amputation. However, concern remains that in attempt close or microscopically positive margins have an adverse effect on event-free survival.(1) Does margin...
Background: Chondroblastoma is a rare benign cartilage tumor that commonly occurs in children and adolescents. This study was designed to review the epidemiologic characteristics outcomes of surgical management large series patients with extremity chondroblastoma. Methods: We performed multicenter retrospective analysis 199 Clinical data, radiographic images, histological findings, treatment, outcome were analyzed. Results: There 145 male fifty-four female mean age 18.0 years. The most...
The optimal treatment of malignant pediatric lower-extremity bone tumors is controversial. Expandable endoprostheses allow limb preservation, but the revision rate and limited function are considered barriers to their use. This study investigated functional, emotional, oncologic outcomes thirty-eight patients treated with an expandable endoprosthesis.A retrospective chart review was performed, surviving were asked complete Musculoskeletal Tumor Society (MSTS) instrument Pediatric Outcomes...
Pathological fractures in children can occur as a result of variety conditions, ranging from metabolic diseases and infection to tumours. Fractures through benign malignant bone tumours should be recognised managed appropriately by the treating orthopaedic surgeon. The most common that cause pathological are unicameral cysts, aneurysmal non-ossifying fibromas fibrous dysplasia. Although primary malignancy rare, these quickly order achieve better outcomes. A thorough history, physical...
Background . Little is known about how cumulative chemotherapy delivery influences the poorer outcome observed in young adult (YA, 18–40 years) versus pediatric (<18 osteosarcoma patients. Here, we retrospectively examined differences presentation, therapy, including dose, and YA Methods We reviewed 111 cases of high-grade at Moffitt Cancer Center between 1988 2012. Presentation factors, therapies, survival were compared cohorts. Results The cohorts equivalent with respect to metastatic...
Transcatheter arterial chemoembolization (TACE) is efficacious against hepatic malignancies by rendering tumors ischemic while delivering high-dose chemotherapy. The added benefit of radiofrequency ablation (RFA) has not been determined. We sought to review our experience with TACE or without RFA in the treatment hepatocellular carcinoma and colorectal liver metastases patients amenable resection. were undertaken 13 (n = 7) 6). Concurrently 24 underwent alone for 15) 9). Patients undergoing...
Soft-tissue sarcomas present as a mass with nonspecific symptoms, and unplanned excisions commonly occur. The purpose of this study was to analyze the incidence performed by orthopaedic surgeons conduct root cause analysis (RCA) steps that led in all cases.
Opioids are widely used perioperatively for pain control. However, growing concerns about opioid-related adverse effects, such as respiratory depression, dependence, and delirium, have driven interest in opioid-free analgesia. These effects can prolong hospital stays complicate recovery. We present the case of a 53-year-old male with risk factors opioid-induced morbidity (BMI &#62;50 obstructive sleep apnoeas [OSA]) who successfully underwent analgesia left total scapulectomy setting...
Ewing sarcoma and osteosarcoma constitute 36% of all primary bone cancers. However, these 2 subtypes represent the most commonly diagnosed cancer types in pediatric adolescent population. Although still largely unknown, certain genetic mutations, rearrangements, and/or predisposition syndromes likely play a role pathogenesis cancer. Osteosarcoma may also develop as direct result long-term side effects radiation therapy. With implementation multimodality approach to treatment, including...
Core needle biopsies of sarcomas allow a diagnosis in high percentage patients with few complications. However, it is unclear whether the tract needs to be excised prevent recurrences.We therefore determined rates recurrence and metastases Stage III extremity sarcomas, who underwent wide local resection without excision also received adjuvant treatment.We retrospectively reviewed 59 adult deep, larger than 5 cm, high-grade soft tissue upper or lower treated between January 1999 April 2009....
Intraoperative radiographic guidance has traditionally been utilized in orthopedic surgery through 2-D navigation with the C-arm and recently 3-D O-arm. The aim of this study was to describe outcome surgical treatment spinal osteoblastoma osteoid osteoma utilization O-arm conventional guidance. This is a retrospective cohort patients or who were treated at our institution between 2002 2011. Seventeen examined including seven 10 osteoma. mean age 11.5±3.9 years. used patients. failed identify...
Abstract Background and Objectives The impact upon wound healing of targeted molecular therapies, when incorporated into neoadjuvant therapy soft tissue sarcoma, is largely unknown. Here, we describe complications following addition pazopanib, a tyrosine kinase inhibitor (TKI), to radiotherapy (RT) +/− chemotherapy for sarcoma. Methods Wound were evaluated on dose‐finding randomized arms ARST1321, phase II/III study incorporating RT, ifosfamide/doxorubicin (ID) sarcoma therapy. Results Of 85...
Sarcomas are a diverse group of malignant tumors that arise from soft tissues or bone. For most advanced cases, there is substantial need for improved therapeutic options and, therefore, desire to more precisely tailor therapy in individual cases. In this study, we review our institutional experience with next-generation sequencing (NGS)-based molecular profiling non-GI stromal sarcomas, focus on the clinical utility results.We retrospectively analyzed results NGS performed 114 patients...
Treatment of chondroblastoma in the femoral head is challenging owing to particular location and its aggressive nature. There little published information guide surgeon regarding appropriate approach treating a this location. We developed modified trapdoor procedure address issue. The primary modification that window surface covered by ligamentum teres rather than cartilage as traditional procedure.We assessed (1) clinical presentation treatment results with terms (2) frequency local...
The treatment of extremity rhabdomyosarcoma remains a challenge due to several adverse prognostic factors frequently associated with this tumor site. International Soft-Tissue Sarcoma Database Consortium (INSTRuCT) is collaboration the Children's Oncology Group Committee, European Pediatric Study Group, and Cooperative Weichteilsarkom Studiengruppe. INSTRuCT surgical committee developed an internationally applicable consensus opinion document for rhabdomyosarcoma. This addresses management,...
Abstract Background Children living in poverty and those of marginalized race or ethnicity experience inferior disease outcomes across many cancers. Whether survival disparities exist osteosarcoma is poorly defined. We investigated the association between race, ethnicity, proxied exposures event-free overall for children with nonmetastatic receiving care on a cooperative group trial. Methods conducted retrospective cohort study US patients nonmetastatic, aged 5-21 years enrolled Children’s...
Abstract Background Aseptic loosening is one of the most common causes revision distal femoral endoprostheses and considered a mid- to long-term complication. There are not many reports 10-year survivorship free from aseptic all-cause in cemented stems. To our knowledge, there no on radiographic features that associated with these implants. Questions/purposes (1) What 5- patients undergoing reconstruction endoprosthesis after tumor resection? (2) at patients? (3) follow-up? Methods We...