A5087193725- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Head and Neck Surgical Oncology
- Advanced MRI Techniques and Applications
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Oral and Maxillofacial Pathology
- Head and Neck Cancer Studies
- Functional Brain Connectivity Studies
- Bone Tumor Diagnosis and Treatments
- Neurological Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Acute Ischemic Stroke Management
- Spine and Intervertebral Disc Pathology
- Cardiac Arrest and Resuscitation
- Spinal Fractures and Fixation Techniques
- Memory and Neural Mechanisms
- Sarcoma Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Brain Metastases and Treatment
- Nanoparticle-Based Drug Delivery
University of California, Davis
2015-2024
University of California Davis Medical Center
2009-2022
Kaiser Permanente San Francisco Medical Center
2022
SUNY Downstate Health Sciences University
2018-2019
State University of New York
2019
University of Iowa
2018
UC Davis Comprehensive Cancer Center
2013
California State University, Sacramento
2012
UC Davis Health System
2009
New York University
1995-2001
Neuropathology studies show that patients with mild cognitive impairment (MCI) and Alzheimer's disease typically have lesions of the entorhinal cortex (EC), hippocampus (Hip), temporal neocortex. Related observations in vivo imaging enabled prediction dementia from MCI. Although individuals normal cognition may focal EC lesions, this anatomy has not been studied as a predictor decline brain change. The objective MRI-guided 2-[ 18 F]fluoro-2-deoxy- d -glucose/positron-emission tomography...
For 11 AD cases and four normal elderly controls, post mortem volumes of the hippocampal subdivisions were calculated by using magnetic resonance imaging histological sections. After at least six weeks fixation in formalin, brains examined on a 1.5-T Philips Gyroscan imager producing T1-weighted coronal images with 3-mm slice thickness. Brains then processed embedded paraffin. Serial sections, 3 mm apart stained Cresyl Violet, used for planimetry unbiased estimation total numbers neurons...
We used CT and MR to examine the frequency of occurrence hippocampal formation atrophy (HA) in a research clinic population 130 normal elderly, 72 nondemented patients with very mild memory cognitive impairments (MCI), 73 Alzheimer's disease (AD) patients, moderate severe AD. HA was found 29% elderly group its strongly related increasing age. For 60-75 years age, 15% had HA: proportion rose 48% subjects 76-90 Among three groups impaired frequencies ranged from 78% MCI 96% advanced AD group....
Current clinical brain imaging techniques used for surgical planning of tumor resection lack intraoperative and real-time feedback; hence surgeons ultimately rely on subjective evaluation to identify areas margins. We report a fluorescence lifetime (FLIm) instrument (excitation: 355 nm; emission spectral bands: 390/40 nm, 470/28 542/50 nm 629/53 nm) that integrates with microscopes provide augmentation the field view fluorescent derived parameters encoding diagnostic information. show...
The hippocampal formations of 13 subjects with severe Alzheimer disease [AD; Global Deterioration Scale (GDS) stage 7] and 5 age-matched without symptoms dementia were reconstructed from serial sections. Functional assessment staging (FAST) was used at the time demise to assess 9 patients stages 7a–c (incipient averbal nonambulatory) 4 7e–f (immobile). duration FAST until ranged 2 8 years in first these subgroups, 10 second. volumes entire formation cornu ammonis, its sectors layers, dentate...
Vascular risk factors (e.g., obesity and hypertension) are associated with cerebral small vessel disease, Alzheimer's disease (AD) pathology, dementia. Reduced perfusion may reflect the impaired ability of blood vessels to regulate flow in reaction varying circumstances such as hypercapnia (increased end-tidal partial pressures CO
The two currently acceptable treatment options for locally advanced laryngeal cancer are total laryngectomy and organ preservation using chemoradiation. To facilitate therapeutic decision making, the accurate pre-treatment evaluation of cartilage invasion is paramount importance. purpose this study was to evaluate positive predictive value (PPV) negative (NPV) detecting neoplastic in patients fast-speed multidetector CT (MDCT).61 consecutive with clinically staged T3 or T4 squamous cell...
<h3>BACKGROUND AND PURPOSE:</h3> Our aim was to evaluate whether serial administration of the macrocyclic gadolinium-based contrast agent gadoteridol in children is associated with T1-weighted hyperintensity within dentate nucleus, an imaging surrogate for gadolinium deposition. <h3>MATERIALS METHODS:</h3> We identified a retrospective cohort 10 patients younger than 18 years age who underwent between 4 and 8 gadoteridol-enhanced MR examinations brain from 2016 2017. For comparison, we 9...
Background and Importance Chondroblastoma is a benign primary bone tumor that typically develops in the epiphyses of long bones. craniofacial skeleton extremely rare, with most cases occurring squamosal portion temporal bone. In this report, we describe first case chondroblastoma clivus presenting cranial neuropathy was treated endoscopic endonasal resection. We review literature on chondroblastomas particular emphasis extratemporal lesions. Case Presentation A 27-year-old woman presented...
Temporal bone computed tomographic (CT) scanning in the postoperative stapedotomy patient is inaccurate assessing stapes piston position within vestibule.Poststapedotomy patients that have persistent vertigo may undergo CT to assess of vestibule rule out overly deep insertion. Vertigo a recognized complication piston, and evaluation often recommended. The accuracy scan this setting unestablished.Stapedotomy was performed on 12 cadaver ears, stainless steel McGee pistons were placed. heads...
Trauma is the leading cause of morbidity and mortality in children United States. The antifibrinolytic drug tranexamic acid (TXA) improves survival adults with traumatic hemorrhage, however, has not been evaluated a clinical trial severely injured children. We designed Traumatic Injury Clinical Trial Evaluating Tranexamic Acid Children (TIC-TOC) to evaluate feasibility conducting confirmatory that evaluates effects TXA severe trauma hemorrhagic injuries. evidence torso or brain injuries will...
The antifibrinolytic drug tranexamic acid (TXA) improves survival in adults with traumatic hemorrhage; however, the has not been evaluated a trial injured children. We assessed feasibility of large-scale evaluating effects TXA children severe hemorrhagic injuries.