A5034573600- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Folate and B Vitamins Research
- Diet and metabolism studies
- Health Literacy and Information Accessibility
- Blood Pressure and Hypertension Studies
- Metabolism and Genetic Disorders
- Bioinformatics and Genomic Networks
- Nutritional Studies and Diet
- Technology Use by Older Adults
- Health, Environment, Cognitive Aging
- Alcoholism and Thiamine Deficiency
- Brain Tumor Detection and Classification
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Clusterin in disease pathology
- Advanced Neuroimaging Techniques and Applications
- Climate Change and Health Impacts
- Cancer-related cognitive impairment studies
- Obstructive Sleep Apnea Research
- COVID-19 and healthcare impacts
- Neurological and metabolic disorders
- Biomedical Text Mining and Ontologies
Erasmus MC
2025
Amsterdam Neuroscience
2015-2020
Karolinska Institutet
2020
Amsterdam University Medical Centers
2018-2020
University College London
2017-2020
Vrije Universiteit Amsterdam
2018-2020
Maastricht University
2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014-2019
Neurology, Inc
2019
Hospital de Sant Pau
2017
Abstract Introduction In this multicenter study on subjective cognitive decline (SCD) in community‐based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) non‐AD dementia (2) determinants progression to dementia. Methods Eleven cohorts provided 2978 participants with SCD 1391 controls. We estimated identified risk factors using Cox proportional hazards models. Results SCD, was 17.7 (95% Poisson confidence interval 15.2‐20.3)/1000 person‐years (AD: 11.5...
Objective We investigated the association of plasma amyloid beta (Abeta)40, Abeta42, and total tau (tTau) with presence Alzheimer pathological changes in cognitively normal individuals subjective cognitive decline (SCD). Methods included 248 subjects SCD (61 ± 9 years, 42% female, Mini‐Mental State Examination = 28 2) from SCIENCe project Amsterdam Dementia Cohort. Subjects were dichotomized as abnormal by cerebrospinal fluid (CSF) positron emission tomography (PET). Baseline Abeta40, tTau...
<h3>Objective</h3> To investigate the relationship between ATN classification system (amyloid, tau, neurodegeneration) and risk of dementia cognitive decline in individuals with subjective (SCD). <h3>Methods</h3> We classified 693 participants SCD (60 ± 9 years, 41% women, Mini-Mental State Examination score 28 2) from Amsterdam Dementia Cohort Subjective Cognitive Impairment (SCIENCe) project according to model, as determined by amyloid PET or CSF β-amyloid (A), p-tau (T), MRI-based medial...
We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, cross-sectionally participant characteristics, and evaluate SCD-plus criteria. The SCIENCe is a prospective cohort of subjective cognitive decline (SCD) patients. Participants undergo extensive assessment, including cerebrospinal fluid collection optional amyloid positron emission tomography scan, with annual follow-up. primary outcome measure clinical progression. Cross-sectional evaluation first 151...
Abstract Introduction Within‐person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. Methods We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild impairment 128), and AD dementia 110), a group cognitively unimpaired 154) also included. measured baseline follow‐up levels total tau (t‐tau), phosphorylated (p‐tau), YKL‐40, neurofilament light...
Abstract Background and purpose There are concerns that the coronavirus disease 2019 (COVID-19) outbreak negatively affects quality of care for acute cardiovascular conditions. We assessed impact COVID-19 on trends in hospital admissions workflow parameters stroke Amsterdam, The Netherlands. Methods used data from three hospitals provide Amsterdam region. compared two 7-week periods: one during peak (March 16th–May 3th 2020) prior to (October 21st–December 8th 2019). included consecutive...
Background: HDL-cholesterol transporter Apolipoprotein A1 (ApoA1) holds neuroprotective properties, such as inhibition of amyloid-β aggregation. Low plasma ApoA1 concentrations are associated with Alzheimer’s disease (AD). Little is known about levels in the pre-dementia stages AD. Objective: To investigate associations between cerebrospinal fluid (CSF) and clinical progression toward AD non-demented elderly. Methods: From Amsterdam Dementia Cohort, we included 429 elderly subjective...
We examined the relationships between amyloid-β PET and concurrent longitudinal cognitive performance in 107 cognitively normal individuals with subjective decline (age: 64 ± 8 years, 44% female, Mini-Mental State Examination score 29 1). All underwent 90-minute dynamic [18F]florbetapir scanning neuropsychological tests a mean follow-up of 3.4 3.0 years. Receptor parametric mapping was used to calculate binding potential (BPND), we performed linear mixed models assess global BPND...
Objective: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's Disease (AD). Early disease processes, such as amyloid-β aggregation measured quantitative PET, may help to explain the phenotype SCD. The aim this study was investigate whether load both self- and informant-reported complaints memory deficit awareness in individuals Methods: We included 106 SCD patients (mean ± SD age: 64 8, 45%F) 90 min dynamic [18F]florbetapir PET scans. used following...
Plasma biomarkers are promising prognostic tools in individuals with subjective cognitive decline (SCD). We aimed to investigate the relationships of baseline plasma amyloid beta (Aβ)42/Aβ40 and total Tau (tTau) rate decline, comparison cerebrospinal fluid (CSF) Aβ42, tTau, phosphorylated tau181 (pTau181) decline. included 241 subjects SCD (age = 61 ± 9, 40% female, Mini-Mental State Examination 28 2) follow-up (average: 2 years, median visits: 3 [range: 1-11]) for re-evaluation...
Abstract Objectives Grey matter network disruptions in Alzheimer's disease (AD) are associated with worse cognitive impairment cross‐sectionally. Our aim was to investigate whether indications of a more random organization longitudinal decline specific functions individuals subjective (SCD). Experimental design : We included 231 SCD who had annually repeated neuropsychological assessment (3 ± 1 years; n = 646 investigations) available from the Amsterdam Dementia Cohort (54% male, age: 63 9,...
Subjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer's disease (AD) dementia and a target population future prevention trials. Currently, however, SCD is heterogeneously defined across studies, potentially leading to variations the prevalence of AD pathology. Here, we compared identified common determinants abnormal biomarkers three European memory clinics participating initiative on harmonization...
Biomarkers such as cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) have predictive value for progression to dementia in patients with mild cognitive impairment (MCI). The pre-dementia stage takes far longer, the interpretation of biomarker findings is particular relevant individuals who present at a memory clinic, but are deemed cognitively normal. objective current study construct biomarker-based prognostic models personalized risk clinical normal presenting clinic.We...
Self-perceived word-finding difficulties are common in aging individuals as well Alzheimer's Disease (AD). Language and speech deficits difficult to objectify with neuropsychological assessments. We therefore aimed investigate whether amyloid, an early AD pathological hallmark, is associated speech-derived semantic complexity. included 63 subjective cognitive decline (age 64 ± 8, MMSE 29 1), amyloid status (positron emission tomography [PET] scans n = 59, or Aβ1-42 cerebrospinal fluid [CSF]...
Abstract Introduction Synaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids. Consequently, insufficient availability such may restrict and contribute to synaptic dysfunction in Alzheimer's disease (AD). We assessed whether blood cerebrospinal fluid (CSF) concentrations related phospholipid differ among patients with AD, mild cognitive impairment (MCI), control subjects. Methods Concentrations uridine, choline, folate,...
We studied whether continuous lower normal cerebrospinal fluid (CSF) amyloid β1‐42 (≥640pg/ml) levels were related with rate of clinical progression in a sample 393 nondemented memory clinic patients. Lower associated faster progression, and this depended on baseline cognitive status (subjective decline: hazard ratio [HR] = 0.57, p < 0.05; mild impairment: HR 0.19, .01), indicating that CSF do not exclude incident Alzheimer disease. These findings suggest research preclinical markers for...
As nutrition is one of the modifiable risk factors for cognitive decline, we studied relationship between dietary quality and clinical characteristics in cognitively normal individuals with subjective decline (SCD). We included 165 SCD subjects (age: 64 ± 8 years; 45% female) from SCIENCe project, a prospective memory clinic based cohort study on SCD. The Dutch Healthy Diet Food Frequency Questionnaire (DHD-FFQ) was used to assess adherence guidelines vegetable, fruit, fibers, fish,...
Abstract Introduction Individuals with subjective cognitive decline (SCD) are at increased risk of Alzheimer's disease and could benefit from a prevention strategy targeting lifestyle factors. Making program available through the Internet gives widespread reach low cost, but suboptimal adherence is major threat to effectiveness. As first step in developing an online (OLP), we aimed identify factors that barriers and/or facilitators for use OLP individuals SCD three European countries....
A lumbar puncture is performed to obtain cerebral spinal fluid. It implemented in the clinic on a routine basis aid diagnosis of neurologic diseases, such as dementia. This video will show procedure routinely VUmc Alzheimer Center.
Abstract Introduction Individuals with subjective cognitive decline (SCD) are at increased risk for clinical progression. We studied how combining different diagnostic tests can help to identify individuals who likely show Methods included 674 patients SCD (46% female, 64 ± 9 years, Mini–Mental State Examination 28 2) from three memory clinic cohorts. A multivariate model based on the Disease Index classifier incorporated available baseline predict progression MCI or dementia over time....
Obstructive sleep apnea syndrome (OSAS) occurs more frequently in Alzheimers disease (AD) than controls. OSAS is characterized by the obstruction of upper airway resulting nocturnal intermittent hypoxia. Hypoxia has been found to be related Alzheimer biomarkers amyloid-beta and tau animal studies. The aim present study was investigate whether a history associated with cerebrospinal fluid (CSF) levels 42 (AB42), total (tau) phosphorylated (ptau) patients subjective cognitive decline (SCD),...
Our aim was to characterize the within-person trajectories of cerebrospinal fluid (CSF) biomarkers along Alzheimer's disease (AD) continuum. We included 407 subjects from multicenter BIOMARKAPD project whom at least two CSF samples were obtained. Baseline diagnosis were: healthy controls (HC=146), subjective cognitive decline (SCD=71), mild impairment (MCI=101), and AD dementia (AD=89). measured baseline follow-up levels amyloid-β (Aβ)1–42, Aβ1–40, Aβ1–38, total tau (t-tau), phosphorylated...