A5059557996- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Functional Brain Connectivity Studies
- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Particle Detector Development and Performance
- Financial Markets and Investment Strategies
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Corporate Finance and Governance
- Particle physics theoretical and experimental studies
- Radiomics and Machine Learning in Medical Imaging
- Brain Tumor Detection and Classification
- Crystallography and molecular interactions
- Neurological disorders and treatments
- Nuclear Physics and Applications
- Auditing, Earnings Management, Governance
- Cerebrospinal fluid and hydrocephalus
- MRI in cancer diagnosis
Mayo Clinic
2016-2025
Mayo Clinic in Arizona
2016-2025
WinnMed
2014-2024
New York University
2008-2024
Alzheimer’s Disease Neuroimaging Initiative
2013-2024
National University of Singapore
2024
National University Health System
2024
University of California, Irvine
2011-2023
GSI Helmholtz Centre for Heavy Ion Research
2012-2023
Mayo Clinic in Florida
2018-2023
See Hansson and Mormino (doi:10.1093/brain/awy065) for a scientific commentary on this article. Our objective was to compare different whole-brain region-specific measurements of within-person change serial tau PET evaluate its utility clinical trials. We studied 126 individuals: 59 cognitively unimpaired with normal amyloid, 37 abnormal 30 impaired an amnestic phenotype amyloid. All had baseline amyloid two PET, MRI, assessments. compared the topography across all cortical regions interest...
ABSTRACT We study the influence of financial innovation by fintech brokerages on individual investors’ trading and stock prices. Using data from Robinhood, we find that Robinhood investors engage in more attention‐induced than other retail investors. For example, outages disproportionately reduce high‐attention stocks. While this evidence is consistent with attracting relatively inexperienced investors, show it also driven part app's unique features. Consistent models trading, intense buying...
Alzheimer's disease (AD) researchers commonly use MRI as a quantitative measure of severity. Historically, hippocampal volume has been favored. Recently, "AD signature" measurements gray matter (GM) volumes or cortical thicknesses have gained attention. Here, we systematically evaluate multiple thickness- and volume-based candidate-methods side-by-side, built using the popular FreeSurfer, SPM, ANTs packages, according to following criteria: (a) ability separate clinically normal individuals...
To study fundamental questions of hadron and nuclear physics in interactions antiprotons with nucleons nuclei, the universal PANDA detector will be built. Gluonic excitations, strange charm quarks nucleon structure studies performed unprecedented accuracy thereby allowing high-precision tests strong interaction. The proposed is a state-of-the art internal target at HESR FAIR detection identification neutral charged particles generated within relevant angular energy range. This report...
See Herholz (doi:10.1093/brain/awx340) for a scientific commentary on this article.Autopsy data have proposed that topographical pattern of tauopathy occurs in the brain with development dementia due to Alzheimer's disease. We evaluated findings tau-PET better understand neurofibrillary tangle as it is seen cognitively unimpaired and impaired individuals. The evolution disease individuals needs be examined pathogenesis. Tau-PET was performed 86 who all had abnormal amyloid levels 601 were...
A National Institute on Aging and Alzheimer's Association workgroup proposed a research framework for Alzheimer disease in which biomarker classification of participants is labeled AT(N) amyloid, tau, neurodegeneration biomarkers.To determine the associations between profiles memory decline population-based cohort individuals without dementia age 60 years or older, to whether biomarkers provide incremental prognostic value beyond more readily available clinical genetic...
Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer's disease (AD) patients (n = 46). Patients with antemortem DTI studies and a range AD pathology at autopsy included. high neurofibrillary tangle (NFT) stage (Braak IV–VI) had significantly elevated mean diffusivity (MD) the crus fornix ventral cingulum tracts, precuneus, entorhinal white matter on voxel-based analysis after adjusting for age time from to death (p < 0.001). Higher MD lower...
Although white matter hyperintensities have traditionally been viewed as a marker of vascular disease, recent pathology studies found an association between and Alzheimer's disease pathologies. The objectives this study were to investigate the topographic patterns associated with biomarkers measured using PET. From population-based Mayo Clinic Study Aging, 434 participants without dementia (55% male) FLAIR gradient recall echo MRI, tau-PET (AV-1451) amyloid-PET scans identified. A subset had...
Large phenotypically diverse research cohorts with both amyloid and tau PET have only recently come into existence. Our objective was to determine relationships between the bivariate distribution of amyloid-β on established clinical syndromes that are relevant cognitive ageing dementia. All individuals in this study were enrolled Mayo Clinic Study Aging, a longitudinal population-based ageing, or Alzheimer Disease Research Center, recruited from practice. We studied 1343 participants who had...
Abstract Introduction Comparison of tau (flortaucipir) positron emission tomography (FTP‐PET) to autopsy is important demonstrate the relationship FTP‐PET neuropathologic findings. Methods Autopsies were performed on 26 participants who had antemortem FTP‐PET. standardized uptake value ratios (SUVRs) compared diagnoses and Braak tangle stage. Quantitative burden was regional signal. Results Participants with stages IV or greater elevated in Alzheimer's disease. An SUVR cut point 1.29...
Abstract Staging the severity of Alzheimer’s disease pathology using biomarkers is useful for therapeutic trials and clinical prognosis. Disease staging with amyloid tau PET has face validity; however, this would be more practical plasma biomarkers. Our objectives were, first, to examine approaches and, second, prediction stages Participants (n = 1136) were enrolled in either Mayo Clinic Study Aging or Research Center; had a concurrent PET, blood draw; met criteria cognitively unimpaired...
The gap between chronological age (CA) and biological brain age, as estimated from magnetic resonance images (MRIs), reflects how individual patterns of neuroanatomic aging deviate their typical trajectories. MRI-derived (BA) estimates are often obtained using deep learning models that may perform relatively poorly on new data or lack interpretability. This study introduces a convolutional neural network (CNN) to estimate BA after training the MRIs 4,681 cognitively normal (CN) participants...
ABSTRACT We placed 85,000 retail trades in six brokerage accounts from December 2021 to June 2022 validate the Boehmer et al. algorithm, which uses subpenny trade prices identify and sign trades. The algorithm identifies 35% of our as retail, incorrectly signs 28% identified trades, yields uninformative order imbalance measures for 30% stocks. modify by signing using quoted spread midpoints. quote midpoint method does not affect identification rates but reduces error 5% provides informative all
Abstract BACKGROUND We compared the ability of several plasma biomarkers versus amyloid positron emission tomography (PET) to predict rates memory decline among cognitively unimpaired individuals. METHODS studied 645 Mayo Clinic Study Aging participants. Predictor variables were age, sex, education, apolipoprotein E ( APOE ) ε 4 genotype, PET, and beta (Aβ)42/40, phosphorylated tau (p‐tau)181, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), p‐tau217. The outcome was a...
ABSTRACT Mandatory disclosure is a regulatory tool intended to allow market participants assess operational risk. We examine the value of through controversial SEC requirement, since overturned, which required major hedge funds register as investment advisors and file Form ADV disclosures. Leverage ownership structures suggest that lenders equity investors were already aware However, risk does not mediate flow‐performance relationships. Investors either lack this information or regard it...
<h3>Objective</h3> To evaluate relationships between magnetic resonance imaging (MRI)–based measures of white matter hyperintensities (WMHs), measured at baseline and longitudinally, 1-year cognitive decline using a large convenience sample in clinical trial design with relatively mild profile cardiovascular risk factors. <h3>Design</h3> Convenience design. <h3>Subjects</h3> A total 804 participants the Alzheimer Disease Neuroimaging Initiative who received MRI scans, testing, evaluations...
Tract-Based Spatial Statistics (TBSS) is a popular software pipeline to coregister sets of diffusion tensor Fractional Anisotropy (FA) images for performing voxel-wise comparisons. It primarily defined by its skeleton projection step intended reduce effects local misregistration. A white matter "skeleton" computed morphological thinning the inter-subject mean FA, and then all voxels are projected nearest location on this skeleton. Here we investigate several enhancements TBSS based recent...
Primary progressive apraxia of speech is a recently described neurodegenerative disorder in which patients present with an isolated and show focal degeneration superior premotor cortex. Little known about how these individuals progress over time, making it difficult to provide prognostic estimates. Thirteen subjects primary underwent two serial comprehensive clinical neuroimaging evaluations 2.4 years apart [median age onset = 67 (range: 49–76), seven females]. All detailed language,...
Background The [18F]AV-1451 positron emission tomography ligand allows the in vivo assessment of tau proteins brain. It shows strong binding Alzheimer's dementia, but little is known about how it performs progressive supranuclear palsy, a primary 4R tauopathy. Objectives objectives this study were to determine whether uptake can be observed palsy and characterize regional distribution when compared with controls dementia. Methods was performed 10 patients probable palsy. These age-...