A5089684856- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Neurological disorders and treatments
- Amyotrophic Lateral Sclerosis Research
- Functional Brain Connectivity Studies
- Language Development and Disorders
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Action Observation and Synchronization
- Cerebrovascular and genetic disorders
- Botulinum Toxin and Related Neurological Disorders
- Voice and Speech Disorders
- Medical Imaging Techniques and Applications
- Cerebral Palsy and Movement Disorders
- EEG and Brain-Computer Interfaces
- S100 Proteins and Annexins
- Autism Spectrum Disorder Research
- Intracerebral and Subarachnoid Hemorrhage Research
Mayo Clinic
2016-2025
WinnMed
2014-2025
Mayo Clinic in Arizona
2015-2024
Mayo Clinic in Florida
2013-2024
Jacksonville College
2019-2020
Research Institute of Radiology
2011-2015
St. Luke's Hospital
2014
University of Rochester
2014
University of Minnesota Rochester
2011
Active Medicine (United Kingdom)
2010
Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity limited variant syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence- consensus-based revision clinical criteria PSP. Methods: searched PubMed, Cochrane, Medline, PSYCInfo databases articles English...
To investigate the effect of age on global and regional brain volumes rates atrophy, to compare directly results based cross-sectional longitudinal data.Thirty-nine healthy control subjects (age range, 31-84 years) underwent serial magnetic resonance imaging assessments. Measurements included whole-brain, temporal lobe, hippocampal, ventricular at baseline for repeat scans.We found significant decreases in whole-brain (P<.001), lobe hippocampal (P =.003) a increase volume (P<.001) with...
Mild cognitive impairment (MCI), particularly the amnestic subtype (aMCI), is considered as a transitional stage between normal aging and diagnosis of clinically probable Alzheimer's disease (AD). The aMCI construct useful it provides an opportunity to assess clinical which in most subjects represents prodromal AD. aim this study was progression cerebral atrophy over multiple serial MRI during period from Thirty-three were selected that fulfilled criteria for had three scans: first scan ∼3...
<b>Objective: </b> To examine the relationship between early clinical features, pathologies, and biochemistry of frontotemporal lobar degenerations (FTLDs), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD). <b>Methods: The authors conducted pathologic reexamination with most recent immunohistochemistry all cases diagnosed FTLD, PSP, CBD 1970 2004. also reviewed features for diagnosis application published research criteria. <b>Results: Of 127 analyzed, 57 had a 49 21...
Total intracranial volume (TIV/ICV) is an important covariate for volumetric analyses of the brain and regions, especially in study neurodegenerative diseases, where it can provide a proxy maximum pre-morbid volume. The gold-standard method manual delineation scans, but this requires careful work by trained operators. We evaluated Statistical Parametric Mapping 12 (SPM12) automated segmentation TIV measurement place also compared with SPM8 FreeSurfer 5.3.0. For T1-weighted MRI acquired from...
A major recent discovery was the identification of an expansion a non-coding GGGGCC hexanucleotide repeat in C9ORF72 gene patients with frontotemporal dementia and amyotrophic lateral sclerosis. Mutations two other genes are known to account for familial dementia: microtubule-associated protein tau progranulin. Although imaging features have been previously reported subjects mutations progranulin, no published C9ORF72. Furthermore, it remains unknown whether there differences atrophy...
<b>Background: </b> Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one the pathologic hallmarks Alzheimer disease (AD). We aimed to determine whether patterns gray matter atrophy from antemortem MRI correlate with Braak staging NFT pathology. <b>Methods: Eighty-three subjects stage III through VI, a diagnosis low- high-probability AD, and within 4 years death were identified. Voxel-based morphometry assessed in each compared 20 control (Braak stages 0 II)....
Dementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimer's disease. However, unlike latter, patterns cerebral atrophy associated DLB have not been well established. The aim this study was to identify a signature pattern in and compare it found Seventy-two patients that fulfilled clinical criteria for probable were age- gender-matched 72 disease controls. Voxel-based morphometry (VBM) used assess grey matter (GM) two patient groups, relative...
The identification of structural changes in the brain on magnetic resonance imaging (MRI) scans is increasingly important study neurological and psychiatric diseases. MRI can be used to identify exclude treatable causes cognitive impairment it has also become
The behavioural variant of frontotemporal dementia is a progressive neurodegenerative syndrome characterized by changes in personality and behaviour. It typically associated with frontal lobe atrophy, although patterns atrophy are heterogeneous. objective this study was to examine case-by-case variability grey matter subjects the investigate whether can be divided into distinct anatomical subtypes. Sixty-six that fulfilled clinical criteria for diagnosis volumetric magnetic resonance imaging...
To use diffusion tensor imaging (DTI) to assess gray matter and white tract in behavioral variant frontotemporal dementia (bvFTD), semantic (SMD), progressive nonfluent aphasia (PNFA).This was a case-control study where 16 subjects with bvFTD, 7 PNFA, 4 SMD were identified matched by age gender 19 controls. All had 3-T head MRI DTI sequence encoding 21 directions. Gray mean diffusivity (MD) assessed using region-of-interest (ROI) voxel-level approach, voxel-based morphometry used patterns of...
TAR DNA-binding protein 43 (TDP-43) is one of the major disease proteins in frontotemporal lobar degeneration with ubiquitin immunoreactivity. Approximately one-fourth subjects pathologically confirmed Alzheimer (AD) have abnormal TDP-43 (abTDP-43) The aim this study was to determine whether AD and abTDP-43 immunoreactivity distinct clinical, neuropsychological, imaging, or pathologic features compared without immunoreactivity.Eighty-four were identified who had a diagnosis AD,...
<h3>Background:</h3> Corticobasal syndrome (CBS) can be associated with different underlying pathologies that are difficult to predict based on clinical presentation. The aim of this study was determine whether patterns atrophy imaging could useful help pathology in CBS. <h3>Methods:</h3> This a case-control 24 patients CBS who had undergone MRI during life and came autopsy. Pathologic diagnoses included frontotemporal lobar degeneration (FTLD) TDP-43 immunoreactivity 5 (CBS-TDP), Alzheimer...
Abstract Objective To test the hypothesis that β‐amyloid (Aβ) burden is associated with rates of brain atrophy. Methods Forty‐five subjects who had been prospectively studied, died, and an autopsy diagnosis low, intermediate, or high probability Alzheimer's disease two volumetric head magnetic resonance imaging scans were identified. Compact total (compact + diffuse) Aβ was measured using a computerized image analyzer software program to detect proportion gray matter occupied by Aβ. Visual...