A5034631626- Functional Brain Connectivity Studies
- Migraine and Headache Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Amino Acid Enzymes and Metabolism
- Ophthalmology and Eye Disorders
- Spinal Dysraphism and Malformations
- Parkinson's Disease Mechanisms and Treatments
- Psychosomatic Disorders and Their Treatments
- Autoimmune Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Atomic and Subatomic Physics Research
- Complement system in diseases
- Neurological disorders and treatments
- Fetal and Pediatric Neurological Disorders
- Heart Rate Variability and Autonomic Control
Capital Medical University
2022-2025
Beijing Tian Tan Hospital
2022-2024
First Affiliated Hospital of Zhengzhou University
2021
New daily persistent headache (NPDH) is a rare primary that highly disabling. The pathophysiology of NDPH still unclear, and we aimed to reveal the underlying mechanism through functional magnetic resonance imaging (fMRI) analysis.In this cross-sectional study, thirty patients with 30 healthy controls (HCs) were recruited. blood oxygen level-dependent (BOLD) sequences all participants obtained using GE 3.0 T system. We performed ReHo, ALFF (conventional band: 0.01-0.08 Hz, slow-5: 0.01-0.027...
Abstract Objective To explore whether MRI‐visible enlarged perivascular spaces (EPVS) are associated with migraine and may serve as a predictor of migraine. Then further its correlation chronification. Methods A total 231 participants (healthy control [HC] = 57, episodic [EM] 59, chronic [CM] 115) were included in this case–control study. 3T MRI device the validated visual rating scale used to assess grades EPVS centrum semiovale (CSO), midbrain (MB), basal ganglia (BG). Comparisons between...
Abstract Background New daily persistent headache (NDPH) is a rare primary disorder characterized by and sudden onset headaches. The pathogenesis of NDPH remains unclear, there are few white matter imaging studies related to NDPH. purpose this study was investigate the micro-structural abnormalities in provided insights into disease based on tract-based spatial statistics (TBSS). Methods Twenty-one patients with 25 healthy controls (HCs) were included study. T1 structural diffusion magnetic...
The pathogenesis of new daily persistent headache (NDPH) is not fully understood. We aim to map aberrant functional connectivity (FC) in patients with NDPH using resting-state magnetic resonance imaging (MRI).Brain structural and MRI data were acquired from 29 37 well-matched healthy controls (HCs) this cross-sectional study. Region interest (ROI) based analysis was used compare FC between HCs, 116 brain regions the automated anatomical labeling (AAL) atlas defined as seeds. correlations...
Abstract Objectives The new daily persistent headache (NDPH) is a rare primary disorder. However, the underlying mechanisms of NDPH remain incompletely understood. This study aims to apply seed‐based analysis explore functional connectivity (FC) brainstem nuclei in patients with using resting‐state magnetic resonance imaging (MRI). Methods FC from region interest (ROI) whole brain voxels was used investigate 29 and 37 well‐matched healthy controls (HCs) 3.0 Tesla MRI. 76 atlas were defined...
Abstract Background New daily persistent headache (NDPH) is a rare primary with unclear pathogenesis. Neuroimaging studies of NDPH are limited, and controversy still exists. Diffusion tensor imaging (DTI) commonly used to study the white matter. However, lacking specificity, potential pathological mechanisms matter microstructural changes remain poorly understood. In addition, intricacy gray structures impedes application DTI model. Here, we applied an advanced diffusion model neurite...
The definitive pathogenic mechanisms underlying chronic migraine (CM) remain unclear. Mounting evidence from functional and structural magnetic resonance imaging (MRI) studies suggests that the caudate nucleus (CN) plays a role in cognitive, sensory, emotional integration of pain information patients with migraine. However, concerning played by CN CM is limited. Here, we used as seed to explore patterns connectivity (FC) among healthy controls (HCs), episodic (EM), CM.We included 25 HCs, 23...
New daily persistent headache (NDPH) is a rare but debilitating primary disorder that poses significant burden on individuals and society. Despite its clinical importance, the underlying pathophysiological mechanisms of NDPH remain unclear. In this study, we aimed to investigate brain structural changes neural activity patterns in patients with using multimodal imaging analysis magnetic resonance (sMRI) combined magnetoencephalography (MEG).Twenty-eight 37 healthy controls (HCs) were...
Cluster headache (CH) is a highly disabling primary disorder with complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications often have limited efficacy and numerous side effects, which frequently fail to meet clinical needs. This study aims identify potential new targets for CH through proteome-wide mendelian randomization (PWMR). We used PWMR estimate the causal effects of plasma proteins on CH. analysis integrated...
Both specific and innate immune responses play important roles in autoimmune encephalitis (AE). We aimed to explore the predictive value of systemic inflammation index (SII) at admission as a peripheral biomarker treatment response AE. A total 146 patients diagnosed with AE First Affiliated Hospital Zhengzhou University from January 1, 2018 September 22, 2020 were retrospectively consecutively analyzed per inclusion criteria divided into two groups according their immunotherapy after 30...
Abstract Background The brain functional network topology in new daily persistent headache (NDPH) is not well understood. In this study, we aim to assess the cortical topological characteristics of NDPH using non-invasive neural signal recordings. Methods Resting-state magnetoencephalography (MEG) was used measure power fluctuations neuronal oscillations from distributed parcels 35 patients with and 40 healthy controls (HCs). Their structural data were collected by 3T MRI. Functional...
To delineate the structural connectome alterations in patients with chronic migraine (CM), episodic (EM), and healthy controls (HCs). The pathogenesis of chronification remains elusive, brain network changes potentially playing a key role. However, there is paucity research employing graph theory analysis to explore whole networks CM EM. individual 60 CM, 34 EM, 39 control participants were constructed by using deterministic diffusion-tensor tractography. Graph metrics including global...
New daily persistent headache (NDPH) is a rare primary disorder characterized by and sudden onset headaches. Specific abnormalities in gray matter white structure are associated with pain, but have not been well studied NDPH. The objective of this work to explore the fiber tracts structural connectivity, which can help reveal unique regional radiomics similarity networks were calculated from T1 weighted (T1w) MRI depict structure. connectivity matrices diffusion metrics like fractional...