A5100445881- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Mental Health Research Topics
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Biological and pharmacological studies of plants
- Phytochemistry and Biological Activities
- Radiation Dose and Imaging
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Effects of Radiation Exposure
- Sparse and Compressive Sensing Techniques
- Psychedelics and Drug Studies
- Microbial Natural Products and Biosynthesis
- Neurotransmitter Receptor Influence on Behavior
- Immunotherapy and Immune Responses
- Amyotrophic Lateral Sclerosis Research
- Fungal Biology and Applications
- Healthcare and Venom Research
- Glycosylation and Glycoproteins Research
- Plant and animal studies
- Berberine and alkaloids research
- Anesthesia and Neurotoxicity Research
- Neural and Behavioral Psychology Studies
Gansu Provincial Center for Disease Control and Prevention
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Tsinghua University
2007-2025
Center for Life Sciences
2020-2025
Lanzhou University
2024-2025
Stanford University
2019-2025
University of Shanghai for Science and Technology
2024-2025
Ministry of Education
2025
University of Illinois Chicago
2024
Shandong University of Science and Technology
2024
Abstract There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or ‘biotypes’ enable stratification of patients with depression and anxiety. We used task-free task-evoked data from a standardized functional magnetic resonance imaging protocol conducted across multiple studies in anxiety when treatment free ( n = 801) after randomization pharmacotherapy behavioral therapy 250). From these patients, we derived personalized interpretable scores...
Bioassay-guided fractionation of the 60% ethanol extract stems Dendrobium nobile using DPPH assay led to isolation two new bibenzyl derivatives, nobilin D (1) and E (2), a fluorenone, nobilone (3), together with seven known compounds (4−10). Their structures were determined on basis spectroscopic analyses. Compounds 1, 2, 4, 7, 8, 10 exhibited significant antioxidant activity higher than or equivalent vitamin C in assay, 3, 7−10 displayed ORAC assay. also stronger inhibitory effects NO...
Although both schizophrenia and gray matter volume (GMV) show high heritability, however, genes accounting for GMV alterations in remain largely unknown. Based on risk identified by the genome-wide association study of Schizophrenia Working Group Psychiatric Genomics Consortium, we used transcription-neuroimaging analysis to test that which these are associated with changes schizophrenia. For each brain tissue sample, expression profiles 196 were extracted from six donated normal brains...
Mutations in the ANXA11 gene, encoding an RNA-binding protein, have been implicated pathogenesis of amyotrophic lateral sclerosis (ALS), but underlying vivo mechanisms remain unclear. This study examines clinical features ALS patients harboring hotspot mutation p.P36R, characterized by late-onset motor neuron disease and occasional multi-system involvement. To elucidate pathogenesis, we developed a knock-in mouse model carrying p.P36R mutation. In both heterozygous homozygous mutant mice,...
A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features adaptive immune system by coupling in vitro somatic hypermutation (SHM) with mammalian cell display. SHM is dependent on action B specific enzyme, activation-induced cytidine deaminase (AID), can be replicated non-B cells through expression recombinant AID. library antibodies, based germline V-gene segments recombined regions was used to isolate low-affinity β nerve growth...
Many RNA-binding proteins, including TDP-43, FUS, and TIA1, are stress granule components, dysfunction of which causes amyotrophic lateral sclerosis (ALS). However, whether a mutant protein disrupts processing in vivo pathogenesis is unknown. Here we establish FUS ALS mutation, p.R521C, knock-in mouse model that carries impaired motor ability late-onset neuron loss. In disease-susceptible neurons, induces mislocalization into granules upregulation ubiquitin, two hallmarks disease pathology....
New daily persistent headache (NPDH) is a rare primary that highly disabling. The pathophysiology of NDPH still unclear, and we aimed to reveal the underlying mechanism through functional magnetic resonance imaging (fMRI) analysis.In this cross-sectional study, thirty patients with 30 healthy controls (HCs) were recruited. blood oxygen level-dependent (BOLD) sequences all participants obtained using GE 3.0 T system. We performed ReHo, ALFF (conventional band: 0.01-0.08 Hz, slow-5: 0.01-0.027...
Berberine, an isoquinoline alkaloid, has been previously demonstrated to possess anti‑breast cancer properties. Tamoxifen is widely used in the prevention and treatment of estrogen receptor-positive breast cancer. Thus, aim present study was assess whether berberine enhanced anticancer effect tamoxifen, underlying mechanism involved this combined tamoxifen-sensitive (MCF-7) tamoxifen-resistant (MCF-7/TAM) cells using MTS, flow cytometry western blot assays. The results indicated that dose‑...
Neurovascular coupling reflects the close relationship between neuronal activity and cerebral blood flow (CBF), providing a new mechanistic insight into health disease. Neuromyelitis optica (NMO) is an autoimmune inflammatory demyelinating disease of central nervous system shows cognitive decline-related brain gray matter abnormalities besides damage optic nerve spinal cord. We aimed to investigate neurovascular alteration its clinical significance in NMO by using regional homogeneity (ReHo)...
Numerous studies report abnormal cerebral cortex volume (CCV) in autism spectrum disorder (ASD); however, genes related to CCV abnormalities ASD remain largely unknown. Here, we identify associated with alterations by performing spatial correlations between the gene expression of 6 donated brains and neuroimaging data from 1,404 patients 1,499 controls. Based on differences two independent meta-analyses individual distributions 404 496 controls, 417 both distributions. These are enriched for...
New daily persistent headache (NDPH) and chronic migraine (CM) are two different types of headaches that might involve vascular dysregulation. There is still a lack clarity about altered brain perfusion in NDPH CM. This study aimed to investigate the cerebral variances CM using multi-delay pseudo-continuous arterial spin-labeled magnetic resonance imaging (pCASL-MRI).Fifteen patients with NDPH, 18 CM, 15 age- sex-matched healthy controls (HCs) were included. All participants underwent 3D...
Abstract Ketamine commonly and rapidly induces dissociative other altered states of consciousness (ASCs) in humans. However, the neural mechanisms that contribute to these experiences remain unknown. We used functional neuroimaging engage key regions brain’s affective circuits during acute ketamine-induced ASCs within a randomized, multi-modal, placebo-controlled design examining placebo, 0.05 mg/kg ketamine, 0.5 ketamine nonclinical adult participants (NCT03475277). Licensed clinicians...
Abstract Background Sleep disturbances are a common occurrence in patients with schizophrenia, yet the underlying pathogenesis remain poorly understood. Here, we performed targeted metabolomics-based approach to explore potential biological mechanisms contributing sleep schizophrenia. Methods Plasma samples from 59 drug-naïve schizophrenia and 36 healthy controls were subjected liquid chromatography-mass spectrometry (LC-MS) metabolomics analysis, allowing for quantification profiling of 271...
N-doped HsGDY showed excellent sensing ability with a high response to ppb levels of NH 3 . N atoms combined ethynyl groups in the skeleton synergistically enhanced ability.
The objective of this paper is to construct a follow-up cohort medical x-ray workers and analyze the risk estimates radiation-induced carcinogenic noncarcinogenic diseases induced by chronic low-dose ionizing radiation exposure in cohort. A fixed study was used. total 159 working radiology departments hospitals Gansu Province from 1950 1980 were selected as group, 149 internal medicine, surgery, other who had not engaged work at same hospital control group. fifth survey also conducted....
Abstract Dysfunction of RNA-binding proteins, including TDP-43 and FUS, has been associated with amyotrophic lateral sclerosis (ALS); however, the underlying mechanisms are largely unknown. Here, we reported that a neuronal upregulation TRIM72 (Tripartite Motif Containing 72) in FUS mutation knockin ALS models slows disease progression. interacts Commander, protein complex for recycling membrane facilitating repair antioxidation. Exosomal is detected patient cerebrospinal fluid (CSF)...
Cognitive impairments contribute significantly to psychosocial dysfunction in major depressive disorder (MDD), yet mechanistically selective treatments targeted these are lacking. We evaluated guanfacine immediate release (GIR), an alpha 2A receptor agonist, as a novel treatment for selectively improving cognitive control circuit function and behavioral performance subtype of depression, the biotype. Seventeen MDD participants this biotype completed 6-8 weeks GIR (target dose: 2mg/night),...
Lung cancer exhibits strong heterogeneity, and its early diagnosis precise subtyping are of great importance, as they can increase the ability to deliver personalized medicines by tailoring therapy regimens. Tissue biopsy, albeit gold standard, is invasive, costly provides limited information about tumor molecular landscape. Exosomes, promising biomarkers for lung cancer, a heterogeneous collection membranous vesicles containing tumor-specific liquid biopsy identify subtypes. However, small...