A5061137931- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Traumatic Brain Injury Research
- Treatment of Major Depression
- Posttraumatic Stress Disorder Research
- Advanced MRI Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Psychosomatic Disorders and Their Treatments
- Child Abuse and Trauma
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Transcranial Magnetic Stimulation Studies
- Neurofibromatosis and Schwannoma Cases
- EEG and Brain-Computer Interfaces
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Dementia and Cognitive Impairment Research
- Epigenetics and DNA Methylation
- Neurological disorders and treatments
Westmead Institute for Medical Research
2015-2024
The University of Sydney
2015-2024
Westmead Hospital
2012-2024
Sydney Local Health District
2024
UNSW Sydney
2017-2023
McLean Hospital
2023
University of Southern California
2023
Westmead Institute
2012-2022
VA Palo Alto Health Care System
2018
Mental Illness Research, Education and Clinical Centers
2018
Abnormalities in functional limbic-anterior cingulate-prefrontal circuits associated with emotional reactivity, evaluation and regulation have been implicated the pathophysiology of major depressive disorder (MDD). However, existing knowledge about structural alterations depression is equivocal based on cohorts limited sample size. This study used voxel-based morphometry (VBM) surface-based cortical thickness to investigate structure these a large well-characterized patient cohort MDD....
Abstract There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or ‘biotypes’ enable stratification of patients with depression and anxiety. We used task-free task-evoked data from a standardized functional magnetic resonance imaging protocol conducted across multiple studies in anxiety when treatment free ( n = 801) after randomization pharmacotherapy behavioral therapy 250). From these patients, we derived personalized interpretable scores...
Importance Cognitive deficits in depression have been associated with poor functional capacity, frontal neural circuit dysfunction, and worse response to conventional antidepressants. However, it is not known whether these impairments combine together identify a specific cognitive subgroup (or “biotype”) of individuals major depressive disorder (MDD), the extent which mediate antidepressant outcomes. Objective To undertake systematic test validity proposed biotype MDD across circuit,...
Existing work demonstrates that obesity is independently associated with cognitive dysfunction and macrostructural brain changes; however, little known about the association between white matter (WM) integrity. We explore this relationship in a large cohort of otherwise healthy subjects. The present study classified 103 adult participants from Brain Resource International Database 21 86 years age without history neurological, medical, or psychiatric illness according to BMI (normal weight,...
White matter (WM) has been shown to be affected in elderly patients with major depressive disorders (MDD). There is only limited evidence of WM structural abnormalities nongeriatric MDD patients. This study investigates microstructural integrity recruited as part the International Study Predict Optimized Treatment Depression clinical trial and establishes validity diffusion tensor imaging measures for investigation depression. Baseline data from 29 participants (11 melancholia) 39 healthy...
Functional neuroimaging studies implicate anterior cingulate and limbic dysfunction in major depressive disorder (MDD) responsiveness to antidepressants. Diffusion tensor imaging (DTI) enables characterisation of white matter tracts that relate these regions.To examine whether DTI measures are useful prognostic biomarkers for MDD.Of the 102 MDD out-patients from International Study Predict Optimized Treatment Depression (iSPOT-D) who provided baseline magnetic resonance (MRI) data, 74...
Abstract Although major depressive disorder (MDD) is associated with altered functional coupling between disparate neural networks, the degree to which such measures are ameliorated by antidepressant treatment unclear. It also unclear whether connectivity can be used as a predictive biomarker of response. Here, we whole-brain analysis identify signatures remission following treatment, and connectomic predictors 163 MDD 62 healthy individuals underwent MRI during pre-treatment baseline 8-week...
Socioeconomic disparities-and particularly differences in educational attainment-are associated with remarkable cognition and behavior across the life-span. Decreased attainment has been linked to increased exposure life stressors, which turn have structural hippocampus amygdala. However, degree is directly anatomical these structures remains unclear. Recent studies children found socioeconomic regional brain volume amygdala childhood adolescence. Here we expand on this work, by...
Obesity is associated with cognitive dysfunction in children and adolescents, although the mechanisms underlying these deficits remain unclear. This study examined associations between body mass index (BMI) regional gray matter volume white integrity 120 healthy adolescents (6–18 years of age) who underwent magnetic resonance diffusion tensor imaging. Bonferroni-corrected partial correlation analyses controlling for demographic clinical characteristics revealed significant inverse...
Cognitive control is the process of employing executive functions, such as attention, planning or working memory, to guide appropriate behaviors in order achieve a specific goal. Functional magnetic resonance imaging studies suggest superordinate cognitive network, comprising dorsal regions lateral prefrontal cortex (DLPFC), anterior cingulate (dACC) and parietal (DPC). How gray matter structure changes across this network throughout neurodevelopment how these impact are not yet fully...
Default mode network (DMN) dysfunction (particularly within the anterior cingulate cortex (ACC) and medial prefrontal (mPFC)) has been implicated in major depressive disorder (MDD); however, its contribution to treatment outcome not clearly established. Here we tested role of DMN functional connectivity as a general differential biomarker for predicting outcomes large, unmedicated adult sample with MDD. Seventy-five MDD outpatients completed fMRI scans before 8 weeks after randomization...
Socioeconomic status is an important predictor of cognitive development and academic achievement. Late adolescence provides a unique opportunity to study how the attainment socioeconomic (in form years education) relates neural development, during time when age-related ongoing. During late it possible disambiguate age- education-related effects on these processes. Here we assessed degree which higher educational was related performance control task, controlling for age. We then used...
Less than 50% of patients with Major Depressive Disorder (MDD) reach symptomatic remission their initial antidepressant medication (ADM). There are currently no objective measures which to reliably predict individuals will achieve ADMs.157 participants MDD from the International Study Predict Optimized Treatment in Depression (iSPOT-D) underwent baseline MRIs and completed eight weeks treatment escitalopram, sertraline or venlafaxine-ER. A score at week 8 7 less on 17 item Hamilton Rating...