Huaigui Liu
A5009623493- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Genetics and Neurodevelopmental Disorders
- Mental Health Research Topics
- Suicide and Self-Harm Studies
- Cognitive Abilities and Testing
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience and Music Perception
- Ocular Infections and Treatments
- Gene expression and cancer classification
- Air Quality and Health Impacts
- Intraocular Surgery and Lenses
- Posttraumatic Stress Disorder Research
- Bipolar Disorder and Treatment
- Pain Management and Placebo Effect
- Traumatic Ocular and Foreign Body Injuries
Tianjin Medical University General Hospital
2015-2025
Tianjin Medical University
2020
Sun Yat-sen University
2020
It has been revealed that abnormal voxel-mirrored homotopic connectivity (VMHC) is present in patients with schizophrenia, yet there are inconsistencies the relevant findings. Moreover, little known about their association brain gene expression profiles. In this study, transcription-neuroimaging analyses using data from Allen Human Brain Atlas and case-control VMHC differences both discovery (meta-analysis, including 9 studies a total of 386 357 controls) replication (separate group-level...
The human frontal pole (FP) approximately corresponds to Brodmann's area 10 and is a highly differentiated cortical with unique cytoarchitectonic characteristics. However, its functional diversity suggestive of the existence subregions. Based on anatomical connection patterns derived from diffusion tensor imaging data, we applied spectral clustering algorithm parcellate right FP into orbital (FPo), lateral (FPl), medial (FPm) This parcellation scheme was validated by corresponding analyses...
Although both schizophrenia and gray matter volume (GMV) show high heritability, however, genes accounting for GMV alterations in remain largely unknown. Based on risk identified by the genome-wide association study of Schizophrenia Working Group Psychiatric Genomics Consortium, we used transcription-neuroimaging analysis to test that which these are associated with changes schizophrenia. For each brain tissue sample, expression profiles 196 were extracted from six donated normal brains...
Schizophrenia is a mental health disorder characterized by functional dysconnectivity. Eigenvector centrality mapping (ECM) has been employed to investigate alterations in connectivity schizophrenia, yet the results lack consistency, and genetic mechanisms underlying these changes remain unclear. In this study, whole-brain voxel-wise ECM analyses were conducted on resting-state magnetic resonance imaging data. A cohort of 91 patients with schizophrenia matched healthy controls included...
Abstract Introduction Human cingulate cortex ( CC ) has been implicated in many functions, which is highly suggestive of the existence functional subregions. Methods In this study, we used resting‐state magnetic resonance imaging (rs‐ fMRI and diffusion tensor DTI to parcellate human based on connectivity (rs FC patterns anatomical AC patterns, analyze rs different subregions, recognize whether parcellation results obtained by two methods were consistent. Results The was divided into six...
The cerebellum contains several cognitive-related subregions that are involved in different functional networks. cerebellar crus II is correlated with the frontoparietal network (FPN), whereas IX associated default-mode (DMN). These two networks anticorrelated and cooperatively implicated cognitive control, which may facilitate motor recovery stroke patients. In present study, we aimed to investigate resting-state connectivity (rsFC) changes 25 subcortical ischemic patients well-recovered...
The human brain is a highly connected and integrated system. Local stroke lesions can evoke reorganization in multiple functional networks. However, the temporally-evolving patterns different networks after remain unclear. Here, we aimed to investigate dynamic evolutionary of connectivity density (FCD) strength (FCS) subcortical involving motor pathways. Eight male patients with left infarctions were longitudinally examined at five time points within year. Voxel-wise FCD analysis was used...
Abstract Working memory is a basic human cognitive function. However, the genetic signatures and their biological pathway remain poorly understood. In present study, we tried to clarify this issue by exploring potential associations pathways among variants, brain morphometry working performance. We first carried out association analyses between 2‐back accuracy 212 image‐derived phenotypes from 1141 Human Connectome Project (HCP) subjects using linear mixed model (LMM). found significantly...
Genome-wide association studies (GWASs) have identified multiple susceptibility loci for Alzheimer’s disease (AD), which is characterized by early and progressive damage to the hippocampus. However, of hippocampal gene expression with AD underlying neurobiological pathways remain largely unknown. Based on genomic transcriptomic data 111 samples summary two large-scale meta-analyses GWASs, a transcriptome-wide study (TWAS) was performed identify genes significant associations between AD. We...
Depression increases the conversion risk from amnestic mild cognitive impairment to Alzheimer's disease with unknown mechanisms. We hypothesize that cumulative genomic for major depressive disorder may be a candidate cause increased risk. Here, we aimed investigate predictive effect of polygenic scores disorder-specific genetic variants (PRSsMDD) on non-depressed disease, and its underlying neurobiological The PRSsMDD could predict patients high showed 16.25% higher rate than those low was...
Apolipoprotein E (APOE) and sortilin-related receptor (SORL1) genes act on the same metabolic pathway have been associated with Alzheimer's disease (AD) characterized by hippocampal impairment. Although effects of APOE resting-state functional connectivity (rsFC) reported, main SORL1 × interactions rsFC in healthy subjects remain largely unknown. Here, we systematically investigated rs2070045, APOE, their interaction young adults. The effect showed that risk ε4 carriers had decreased...
Abstract The human orbitofrontal cortex (OFC) is an enigmatic brain region that cannot be parcellated reliably using diffusional and functional magnetic resonance imaging (fMRI) because there signal dropout results from inherent defect in techniques. We hypothesise the OFC can into subregions based on gray matter volume (GMV) covariance patterns are derived artefact‐free structural images. A total of 321 healthy young subjects were examined by high‐resolution MRI. was subregions‐based GMV...
Diverse brain structural and functional changes have been reported in schizophrenia. Identifying different types of may help to understand the neural mechanisms develop reliable biomarkers We aimed categorize grey matter schizophrenia based on volume (GMV) cerebral blood flow (CBF). Structural perfusion magnetic resonance imaging data were acquired 100 patients 95 healthy comparison subjects. Voxel-based GMV was used show changes, CBF analysis demonstrate changes. identified three...
Genetic variations of APOE and KIBRA have been associated with human memory Alzheimer's disease. can jointly modulate glutamate receptor to influence long-term potentiation; however, their interactions on brain functional connectivity remain unknown. Here, we investigated additive epistatic between (rs17070145) density (FCD) in 267 healthy young adults. A voxel-based FCD analysis was performed identify regions significant APOE–KIBRA interaction. Additive effects showed decreased the left...
Background and Purpose— The human supplementary motor area (SMA) contains two functional subregions of the SMA proper preSMA, however, reorganization patterns after stroke remain uncertain. Meanwhile, a focal subcortical lesion may affect overall brain networks. We sought to identify differential using resting-state connectivity (rsFC) analysis. Methods—Resting-state MRI was conducted in 25 patients with chronic capsular exhibiting well-recovered global function (Fugl-Meyer score > 90)....
Although extensive resting-state functional connectivity (rsFC) changes have been reported in schizophrenia, rsFC the temporal pole (TP) remain unknown. The TP contains several subregions with different connection patterns; however, it is not known whether are differentially affected schizophrenia. Sixty-six schizophrenia patients and 76 healthy comparison subjects underwent fMRI using a sensitivity-encoded spiral-in (SENSE-SPIRAL) imaging sequence to reduce susceptibility-induced signal...
Abstract Background and Hypothesis The gut-brain axis plays important roles in both gastrointestinal diseases (GI diseases) schizophrenia (SCZ). Moreover, GI SCZ exhibit notable abnormalities brain subcortical volumes. However, the genetic mechanisms underlying comorbidity of these shared alterations volumes remain unclear. Study Design Using genome-wide association studies data SCZ, 14 volumes, 8 diseases, global polygenic overlap local correlations were identified, as well variants among...
Abstract Background Childhood trauma is one of the most extensively studied and well-supported environmental risk factors for development mental health problems. The human tryptophan hydroxylase 2 (TPH2) gene promising candidate genes in numerous psychiatric disorders. However, it now widely acknowledged that neither genetic variation nor exposure alone can fully explain all phenotypic variance observed Therefore, necessary to consider interaction between two research. Methods We enrolled a...