A5100656539- Animal Nutrition and Physiology
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Livestock and Poultry Management
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- Salmonella and Campylobacter epidemiology
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Aquaculture Nutrition and Growth
- Microbial Metabolites in Food Biotechnology
- Diet, Metabolism, and Disease
- Aquaculture disease management and microbiota
- RNA Research and Splicing
- Genetic Associations and Epidemiology
- RNA and protein synthesis mechanisms
- Phytochemicals and Antioxidant Activities
Jinan University
2025
Liaocheng University
2025
Chinese Academy of Agricultural Sciences
2014-2024
Lanzhou Veterinary Research Institute
2024
Lanzhou University
2024
Institute of Animal Sciences
2014-2024
Ministry of Agriculture and Rural Affairs
2020-2024
Anhui Agricultural University
2023
Institute of Animal Science
2022
State Key Laboratory of Animal Nutrition
2012-2021
Rose-comb, a classical monogenic trait of chickens, is characterized by drastically altered comb morphology compared to the single-combed wild-type. Here we show that Rose-comb caused 7.4 Mb inversion on chromosome 7 and second allele arose unequal crossing over between wild-type chromosome. The phenotype relocalization MNR2 homeodomain protein gene leading transient ectopic expression during development. We also provide molecular explanation for first example epistatic interaction reported...
Investigating the genetic markers and genomic signatures related to chicken meat production by combing multi-omics methods could provide new insights into modern breeding technology systems. Chicken is one of most efficient environmentally friendly livestock, especially fast-growing white-feathered (broiler), which well known for high yield, but underlying basis poorly understood. We generated whole-genome resequencing three purebred broilers (n = 748) six local breeds/lines 114), sequencing...
Transcripts and protein for follicle-stimulating hormone receptor (FSHR) were demonstrated in abdominal adipose tissue of female chickens. There was no expression the Fsh gene, but FSH FSHR colocalized, suggesting that bound. Partial correlations indicted changes fat (AF) content most directly correlated with Fshr mRNA expression, latter content. These relationships consistent inducing finding influenced accumulation AF chickens, a novel role hormone. Chicken preadipocytes responded linearly...
Significance Papillary thyroid carcinoma (PTC) displays a strong hereditary component that is, in part, due to the additive effects of numerous low-penetrance genes or variants, but virtually no mechanistic information is available. Here, we studied well-known variant (SNP rs965513) located region devoid coding genes. We show at least four variants immediate vicinity rs965513 reside enhancer elements bind promoter shared by two adjacent thyroid-related genes, forkhead box E1 ( FOXE1 ) and...
Toll-like receptors (TLRs) signaling pathways are the first lines in defense against Salmonella enteritidis (S. enteritidis) infection but molecular mechanism underlying susceptibility to S. chicken remains unclear. SPF chickens injected with were partitioned into two groups, one consisted of those from Salmonella-susceptible (died within 5 d after injection, n = 6), other six Salmonella-resistant that survived for 15 injection. The present study shows bacterial load susceptible was...
Improving the feed efficiency would increase profitability for producers while also reducing environmental footprint of livestock production. This study was conducted to investigate relationships among traits and metabolizable in 180 male broilers. Significant loci genes affecting were explored with an imputation-based genome-wide association study. The measured or calculated comprised three growth traits, five related nine traits.The residual intake (RFI) showed moderate high positive...
Abstract Background Feed accounts for about 70% of the total cost poultry meat production. Residual feed intake (RFI) has become preferred measure efficiency because it is phenotypically independent growth rate and body weight. In this study, our aim was to estimate genetic parameters identify quantitative trait loci (QTL) in 3314 purebred broilers using a genome-wide association study. Broilers were genotyped custom 55 K single nucleotide polymorphism (SNP) array. Results Estimates genomic...
In broiler production, there is a continuous effort to breed feed efficient chickens. Residual intake (RFI) an accurate indicator that has been accepted as alternative measure of the conventional conversion ratio. This study conducted duodenal transcriptome survey explore molecular basis RFI. Results showed are 599 genes were differentially expressed (DE) in duodenum between high RFI and low (LRFI) broilers. Functional analysis can be explained by differences regulation immune system...
Fat traits are important in the chicken industry where there is a desire for high intramuscular fat (IMF) and low abdominal fat. However, limited knowledge on relationship between dynamic status of gene expression body deposition chicken. Transcriptome data were obtained from breast muscle female chickens nine developmental stages (from embryonic day 12 to hatched 180). In total, 8,545 genes 6,824 identified as developmentally genes. Weighted correlation network analysis was used identify...
Abstract We investigated the effects of inulin on intestinal barrier function and mucosal immunity in Salmonella enterica serovar Enteritidis (SE)–infected specific pathogen-free (SPF) chickens. SPF chickens (n = 240, 1-d-old) were divided into 4 groups (6 replicates per group, 10 replicate): a control group (CON) fed basal diet without supplementation 3 SE-infected supplemented with 0% (SE group), 0.5% (0.5% InSE 1% (1% respectively. At 28 d age, orally infected SE CON administrated...
Due to high selection advances and shortened generation interval, genomic (GS) is now an effective animal breeding scheme. In broilers, many studies have compared the accuracy of different GS prediction methods, but few reports demonstrated phenotypic or genetic changes using GS. this study, paternal chicken line B underwent continuous for 3 generations. The 55 k SNP chip was used estimate parameters detect response regions by selective sweep analysis. heritability body weight (BW), meat...
Stay-green syndrome (SGS) resistant germplasms serve as the cornerstone for soybean improvement. A comprehensive assessment was conducted on a panel of 1553 to evaluate their resistance SGS through natural inoculation. Over three-year period, one landrace, ZaoShuHeiDou, emerged resilient SGS, displaying significantly reduced risk (p < 0.05) compared its counterparts. The broad-sense heritability 0.86. Notably, landraces demonstrated substantially lower incidence improved cultivars....
The lipid from egg yolk is largely consumed in supplying the energy for embryonic growth until hatching. remaining sac transported into hatchling's tissues. gene expression profiles of fast- and slow-growing chickens, Arbor Acres (AA) Beijing-You (BJY), were determined to identify global differentially expressed genes enriched pathways related metabolism pectoralis major at Between these two breeds, absolute weight-specific amounts total (TYE) intramuscular fat (IMF) content fast-growing...
Fatty liver is a widespread disease in chickens that causes decrease egg production and even death. The characteristics of the inherited phenotype acquired fatty molecular mechanisms underlying it, however, are largely unknown. In current study, was induced 3 breeds by high-fat (HF) diet methionine choline-deficient (MCD) diet. results showed dwarf Jingxing-Huang (JXH) chicken more susceptible to compared with layer White Leghorns (WL) local Beijing-You (BJY) breeds. addition, it found...
The current study investigated the effects of inulin on gut microbiota, microbiome functions, and short-chain fatty acids (SCFAs) levels in specific pathogen-free (SPF) chickens infected with Salmonella enteritidis (SE). SPF Arbor Acres ( n = 240, 1-day-old) were divided into four groups: a control group (CON) fed basal diet without supplementation or SE infection, three groups supplemented 0, 0.5, 1% (SE, 0.5%InSE, 1%InSE, respectively) up to 28-days-old, followed by challenge at 28 days...
Folate, an essential vitamin participating in 1-carbon metabolism leading to a methyl donor function, is key factor inducing epigenetic changes. This study sought determine if folate influences the methylation level of cytosine-guanine (CpG) islands promoters critical adipogenic genes chickens, and how this might affect gene expression differentiation preadipocytes vitro. Preadipocytes were treated with 0 16 mg/L during induction differentiation, cell proliferation lipid accumulation...
Abstract Working memory is a basic human cognitive function. However, the genetic signatures and their biological pathway remain poorly understood. In present study, we tried to clarify this issue by exploring potential associations pathways among variants, brain morphometry working performance. We first carried out association analyses between 2‐back accuracy 212 image‐derived phenotypes from 1141 Human Connectome Project (HCP) subjects using linear mixed model (LMM). found significantly...
High-salt (HS) intake contributes to hypertension and cardiopathy, but the effect of HS on fat deposition is controversial. Feed intake, mass, percentage abdominal fat, heat production, rate oxygen consumption respiratory exchange ratio mice a diet were significantly decreased (P < 0.01 or 0.05) compared with normal-salt (NS) diet. An in vitro experiment differentiating pre-adipocytes showed reduced presence high concentrations NaCl (>0.05 M). Abdominal mRNA profiles protein measurements...