A5021455364- Animal Nutrition and Physiology
- Livestock and Poultry Management
- Genetic and phenotypic traits in livestock
- Animal Virus Infections Studies
- Coccidia and coccidiosis research
- Chromosomal and Genetic Variations
- Genetic Mapping and Diversity in Plants and Animals
- melanin and skin pigmentation
- Animal Genetics and Reproduction
- Meat and Animal Product Quality
- Animal Disease Management and Epidemiology
- Microbial infections and disease research
- Immune Cell Function and Interaction
- Genomics and Phylogenetic Studies
- T-cell and B-cell Immunology
- RNA and protein synthesis mechanisms
- Genetic diversity and population structure
- interferon and immune responses
- Gut microbiota and health
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Biochemical Analysis and Sensing Techniques
- Molecular Biology Techniques and Applications
- Silkworms and Sericulture Research
Institut de Systématique, Évolution, Biodiversité
2018-2024
AgroParisTech
2012-2023
Université Paris-Saclay
2016-2023
École Pratique des Hautes Études
2020-2023
Sorbonne Université
2020-2023
Centre National de la Recherche Scientifique
2001-2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2023
Génétique Animale et Biologie Intégrative
2013-2022
Université des Antilles
2022
Aarhus University
2021
The domestication of the chicken over a period several thousand years and its later specialization into meat producing (broiler) egg (layer) lines is an informative model phenotypic evolution. A study using massively parallel sequencing domestic wild ancestor, red jungle fowl, reveals number 'selective sweeps', where benign genetic variations closely linked to mutation that dramatically enhances survival increase in frequency relative other alleles. Most striking these — found all chickens...
Yellow skin is an abundant phenotype among domestic chickens and caused by a recessive allele (W*Y) that allows deposition of yellow carotenoids in the skin. Here we show one or more cis-acting tissue-specific regulatory mutation(s) inhibit expression BCDO2 (beta-carotene dioxygenase 2) Our data imply are taken up from circulation both genotypes but degraded animals carrying white (W*W). Surprisingly, our results demonstrate does not originate red junglefowl (Gallus gallus), presumed sole...
The major histocompatibility complex (MHC) is present within the genomes of all jawed vertebrates. MHC genes are especially important in regulating immune responses, but even after over 80 years research on MHC, much remains to be learned about how it influences adaptive and innate responses. In most species, highly polymorphic polygenic. Strong reproducible associations established for chicken MHC-B haplotypes a number infectious diseases. Here, we report (1) development high-density SNP...
Pea-comb is a dominant mutation in chickens that drastically reduces the size of comb and wattles. It an adaptive trait cold climates as it heat loss makes chicken less susceptible to frost lesions. Here we report caused by massive amplification duplicated sequence located near evolutionary conserved non-coding sequences intron 1 gene encoding SOX5 transcription factor. This must be causative since all other polymorphisms associated with allele were excluded genetic analysis. controls cell...
Abstract Background The domestic pig is known as an excellent model for human immunology and the two species share many pathogens. Susceptibility to infectious disease one of major constraints on swine performance, yet structure function genes comprising immunome are not well-characterized. completion genome provides opportunity annotate immunome, compare contrast immune systems. Results Immune Response Annotation Group (IRAG) used computational curation manual annotation assembly 10.2...
The International Crocodilian Genomes Working Group (ICGWG) will sequence and assemble the American alligator (Alligator mississippiensis), saltwater crocodile (Crocodylus porosus) Indian gharial (Gavialis gangeticus) genomes. status of these projects our planned analyses are described.
Rose-comb, a classical monogenic trait of chickens, is characterized by drastically altered comb morphology compared to the single-combed wild-type. Here we show that Rose-comb caused 7.4 Mb inversion on chromosome 7 and second allele arose unequal crossing over between wild-type chromosome. The phenotype relocalization MNR2 homeodomain protein gene leading transient ectopic expression during development. We also provide molecular explanation for first example epistatic interaction reported...
A genomic database of all Earth's eukaryotic species could contribute to many scientific discoveries; however, only a tiny fraction have information available. In 2018, scientists across the world united under Earth BioGenome Project (EBP), aiming produce high-quality reference genomes containing ~1.5 million recognized species. As European node EBP, Reference Genome Atlas (ERGA) sought implement new decentralised, equitable and inclusive model for producing genomes. For this, ERGA launched...
Abstract S*S (Silver), S*N (wild type/gold), and S*AL (sex-linked imperfect albinism) form a series of alleles at the S (Silver) locus on chicken (Gallus gallus) chromosome Z. Similarly, sex-linked albinism (AL*A) is bottom recessive allele orthologous AL in Japanese quail (Coturnix japonica). The solute carrier family 45, member 2, protein (SLC45A2), previously denoted membrane-associated transporter (MATP), has an important role vesicle sorting melanocytes. Here we report five SLC45A2...
Previous studies suggested that multiple domestication events in South and South-East Asia (Yunnan surrounding areas) India have led to the genesis of modern domestic chickens. Ha Giang province is a northern Vietnamese region, where local chickens, such as H'mong breed, wild junglefowl coexist. The assumption was made hybridisation between chickens may occurred high genetic diversity previously observed. objectives this study were i) clarify structure chicken population within ii) give...
Vertebrate skin is characterized by its patterned array of appendages, whether feathers, hairs, or scales. In avian the distribution feathers occurs on two distinct spatial levels. Grouping within discrete tracts, with bare lying between termed macropattern, while smaller scale periodic spacing individual referred to as micropattern. The degree integration patterning mechanisms that operate these scales during development and underlying remarkable evolvability macropatterns are unknown. A...
The Dark brown (DB) mutation in chickens reduces expression of black eumelanin and enhances red pheomelanin, but only certain parts the plumage. Here, we present genetic evidence that an 8.3-kb deletion upstream SOX10 transcription start site is causal underlying DB phenotype. factor has a well-established role melanocyte biology essential for migration survival. Previous studies have demonstrated mouse homolog highly conserved element within deleted region enhancer. mechanism action this...
Many studies in human genetics compare informativeness of single-nucleotide polymorphisms (SNPs) and microsatellites (single sequence repeats; SSR) genome scans, but it is difficult to transfer the results directly livestock because different population structures. The aim this study was determine number SNPs needed obtain same differentiation power as with a given standard set microsatellites. Eight chicken breeds were genotyped for 29 SSRs 9216 SNPs. After filtering, only 2931 remained....
In humans, the clinical and molecular characterization of sporadic syndromes is often hindered by small number patients difficulty in developing animal models for severe dominant conditions. Here we show that availability large data sets whole-genome sequences, high-density SNP chip genotypes extensive recording phenotype offers an unprecedented opportunity to quickly dissect genetic architecture conditions livestock. We report on identification seven de novo mutations CHD7, COL1A1, COL2A1,...
Genomic imprinting is an epigenetic mechanism by which alleles of some specific genes are expressed in a parent-of-origin manner. It has been observed mammals and marsupials, but not birds. Until now, only few orthologous to mammalian imprinted ones have analyzed chicken did demonstrate any evidence this species. However, several published observations such as imprinted-like QTL poultry or reciprocal effects keep the question open. Our main objective was thus screen entire genome for...
In addition to their common usages study gene expression, RNA-seq data accumulated over the last 10 years are a yet-unexploited resource of SNPs in numerous individuals from different populations. SNP detection by is particularly interesting for livestock species since whole genome sequencing expensive and exome tools unavailable. These detected expressed regions can be used characterize variants affecting protein functions, cis -regulated genes analyzing allele-specific expression (ASE)...
Summary French and Asian subsets of chicken breeds were first analysed using 22 microsatellites then compared to the AVIANDIV European set 14 loci. Positive correlations observed between F IT or ST typological values variance markers multivariate analysis mcoa . The axis representation separated from breeds, revealing with ancestor. Using all loci, correct assignation rate was always higher than 93%. Weitzman index aggregate diversity D calculated loci within breeds. breed Coucou de Rennes...
The lavender phenotype in the chicken causes dilution of both black (eumelanin) and red/brown (phaeomelanin) pigments. Defects three genes involved intracellular melanosomal transport, previously described mammals, give rise to similar diluted pigmentation phenotypes as those seen chickens.We have used a candidate-gene approach based on an expectation homology with mammals isolate gene chicken. Comparative sequence analysis candidate identified strong association between mutation MLPH...
Abstract Background In all organisms, life-history traits are constrained by trade-offs, which may represent physiological limitations or be related to energy resource management. To detect trade-offs within a population, one promising approach is the use of artificial selection, because intensive selection on trait can induce unplanned changes in others. chickens, breeding industry has achieved remarkable genetic progress production and feed efficiency over last 60 years. However, this have...
The MITF (microphthalmia-associated transcription factor) gene has been investigated in mice and various vertebrates but its variations associated effects have not yet explored much birds. present study describes the causal mutation B at responsible for "silver" plumage colour Japanese quail (Coturnix japonica), on growth body composition, tests allelism with "blue" Bl Gallus gallus.The semi dominant results from a premature stop codon caused by 2 bp deletion exon 11 of MITF. Homozygous...
Abstract Background The chicken karyotype is composed of 39 chromosome pairs, which 9 still remain totally absent from the current genome sequence assembly, despite international efforts towards complete coverage. Some others are only very partially sequenced, amongst microchromosome 16 (GGA16), particularly under-represented, with 433 kb assembled for a full estimated size to 11 Mb. Besides obvious need coverage genetic markers QTL (Quantitative Trait Loci) mapping and major genes...