A5004588153- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Cancer-related molecular mechanisms research
- Skin and Cellular Biology Research
- Genetic diversity and population structure
- Genomics and Rare Diseases
- Reproductive Physiology in Livestock
- Microbial Metabolism and Applications
- Neurological diseases and metabolism
- dental development and anomalies
- Wheat and Barley Genetics and Pathology
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Reproductive Biology and Fertility
- Connective tissue disorders research
- melanin and skin pigmentation
- Mycobacterium research and diagnosis
- Dermatological and Skeletal Disorders
- Inflammatory Myopathies and Dermatomyositis
- Bone fractures and treatments
- Genomics and Phylogenetic Studies
- Plant and fungal interactions
- Forensic and Genetic Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Génétique Animale et Biologie Intégrative
2014-2024
Université Paris-Saclay
2016-2024
AgroParisTech
2009-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
École Nationale Vétérinaire d'Alfort
2024
Association for Language Learning
2015-2021
Maison des Sciences de l'Homme
2016
Université de Tours
2015
Centre National de la Recherche Scientifique
2015
Terres Univia
2011-2015
The regular decrease of female fertility over time is a major concern in modern dairy cattle industry. Only half this explained by indirect response to selection on milk production, suggesting the existence other factors such as embryonic lethal genetic defects. Genomic regions harboring recessive deleterious mutations were detected three breeds identifying frequent haplotypes (>1%) showing deficit homozygotes among Illumina Bovine 50k Beadchip haplotyping data from French genomic database...
Despite massive research efforts, the molecular etiology of bovine polledness and developmental pathways involved in horn ontogenesis are still poorly understood. In a recent article, we provided evidence for existence at least two different alleles Polled locus identified candidate mutations each them. None these was located known coding or regulatory regions, thus adding to complexity understanding basis polledness. We confirm previous results here exhaustively identify causative mutation...
Detecting the molecular basis of adaptation is one major questions in population genetics. With advance sequencing technologies, nearly complete interrogation genome-wide polymorphisms multiple populations becoming feasible some species, with expectation that it will extend quickly to new ones. Here, we investigate advantages for detection adaptive loci populations, exploiting a recently published data set cattle (Bos taurus). We used two different approaches detect statistically significant...
In humans, the clinical and molecular characterization of sporadic syndromes is often hindered by small number patients difficulty in developing animal models for severe dominant conditions. Here we show that availability large data sets whole-genome sequences, high-density SNP chip genotypes extensive recording phenotype offers an unprecedented opportunity to quickly dissect genetic architecture conditions livestock. We report on identification seven de novo mutations CHD7, COL1A1, COL2A1,...
The absence of horns, called polled phenotype, is the favored trait in modern cattle husbandry. To date, are obtained primarily by dehorning calves. Dehorning a practice that raises animal welfare issues, which can be addressed selecting for genetically hornless cattle. In past 20 years, there have been many studies worldwide to identify unique genetic markers complete association with and recently, two different alleles at POLLED locus, both resulting were reported: (1) Celtic allele,...
The developmental pathways involved in horn development are complex and still poorly understood. Here we report the description of a new dominant inherited syndrome bovine Charolais breed that have named type 2 scurs. Clinical examination revealed that, despite strong phenotypic variability, all affected individuals show both abnormalities similar to classical scurs phenotype skull interfrontal suture synostosis. Based on genome-wide linkage analysis using Illumina BovineSNP50 BeadChip...
In this paper, we developed a highly sensitive approach to detect interchromosomal rearrangements in cattle by searching for abnormal linkage disequilibrium patterns between markers located on different chromosomes large paternal half-sib families genotyped as part of routine genomic evaluations. We screened 5571 artificial insemination sires from 15 breeds and revealed 13 putative rearrangements, 12 which were validated cytogenetic analysis long-read sequencing. These consisted one...
niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Domestication and artificial selection have resulted in strong genetic drift, relaxation of purifying accumulation deleterious mutations. As a consequence, bovine breeds experience regular outbreaks recessive defects which might represent only the tip iceberg since their detection depends on observation affected animals with distinctive symptoms. Thus, mutations resulting embryonic mortality or non-specific symptoms are likely to be missed. The increasing availability whole-genome sequences...
Abstract In the course of evolution, pecorans (i.e., higher ruminants) developed a remarkable diversity osseous cranial appendages, collectively referred to as “headgear,” which likely share same origin and genetic basis. However, nature function determinants underlying their number position remain elusive. Jacob other rare populations sheep goats are characterized by polyceraty, presence more than two horns. Here, we characterize distinct POLYCERATE alleles in each species, both associated...
We used genome-wide SNP data from 18 local cattle breeds six countries of the Alpine region to characterize population structure and identify genomic regions underlying positive selection. The geographically close Evolèner, Eringer, Valdostana Pezzata Nera, Castana were found differ all other breeds. In addition, three breeds, Simmental, Original Braunvieh Switzerland Pinzgauer Austria built separate clusters. Of studied, intra-alpine Swiss breed Evolèner had highest average inbreeding based...
Polled and Multisystemic Syndrome (PMS) is a novel developmental disorder occurring in the progeny of single bull. Its clinical spectrum includes polledness (complete agenesis horns), facial dysmorphism, growth delay, chronic diarrhea, premature ovarian failure, variable neurological cardiac anomalies. PMS also characterized by deviation sex-ratio, suggesting male lethality during pregnancy. Using Mendelian error mapping whole-genome sequencing, we identified 3.7 Mb deletion on paternal...
Curly horses present a variety of curl phenotypes that are associated with various degrees curliness coat, mane, tail and ear hairs. Their origin is still matter debate several genetic hypotheses have been formulated to explain the diversity in phenotype, including combination autosomal dominant recessive alleles. Our purpose was map curly hair locus identify causal variant using genome-wide association study (GWAS) whole-genome sequencing approaches.A GWAS performed Bayesian sparse linear...