A5063292856- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Cancer-related molecular mechanisms research
- Milk Quality and Mastitis in Dairy Cows
- Molecular Biology Techniques and Applications
- Genetic diversity and population structure
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Reproductive Biology and Fertility
- French Urban and Social Studies
- Viral gastroenteritis research and epidemiology
- Linguistics and Discourse Analysis
- Reproductive Physiology in Livestock
- Animal Nutrition and Physiology
- Livestock Farming and Management
- Animal Virus Infections Studies
- Agriculture and Rural Development Research
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Banana Cultivation and Research
- Probiotics and Fermented Foods
- Plant Virus Research Studies
- Effects of Environmental Stressors on Livestock
- Plant tissue culture and regeneration
École Nationale Vétérinaire de Toulouse
2016-2025
Génétique Physiologie et Systèmes d'Elevage
2016-2025
Université de Toulouse
2016-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2018-2025
Institut National Polytechnique de Toulouse
2013-2022
Département Biologie et Amélioration des Plantes
2021
École Nationale Supérieure Agronomique de Toulouse
2013-2016
Laboratoire de Génétique Cellulaire
2005-2014
Laboratoire de Génie Chimique
2009-2013
Institut National de la Recherche Agronomique
1998-2009
An instrument for whole-genome optical mapping is used to assemble the genome of domestic goat into super-long scaffolds. We report ∼2.66-Gb sequence a female Yunnan black goat. The was obtained by combining short-read sequencing data and from high-throughput instrument. facilitated assembly super-scaffolds >5× longer N50 metric than scaffolds augmented fosmid end (scaffold = 3.06 Mb, super-scaffold 16.3 Mb). Super-scaffolds are anchored on chromosomes based conserved synteny with cattle,...
Abstract We describe the organization of a nascent international effort, Functional Annotation Animal Genomes (FAANG) project, whose aim is to produce comprehensive maps functional elements in genomes domesticated animal species.
The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as domestic species become genome-enabled. Before established worldwide, sheep goats were domesticated in the fertile crescent 10,500 years before present (YBP) where their wild relatives remain. Here we sequence genomes Asiatic mouflon Bezoar ibex goat center compare with that domestics from local, traditional, improved breeds. Among genomic regions carrying...
The success of Genome Wide Association Studies in the discovery sequence variation linked to complex traits humans has increased interest high throughput SNP genotyping assays livestock species. Primary goals are QTL detection and genomic selection. purpose here was design a 50–60,000 chip for goats. moderate density assay depends on reliable bioinformatic procedures, technological rate design, even spacing SNPs genome selection Minor Allele Frequencies (MAF) suitable use diverse breeds....
The INRA-Minnesota Porcine Radiation Hybrid (IMpRH) Server provides both a mapping tool (IMpRH tool) and database database) of officially submitted results. permits the new marker relatively to markers previously mapped on IMpRH panel. is official for submission results queries. not only sharing public data but also semi-private private data.
Some sheep breeds are naturally prolific, and they very informative for the studies of reproductive genetics physiology. Major genes increasing litter size (LS) ovulation rate (OR) were suspected in French Grivette Polish Olkuska populations, respectively. To identify genetic variants responsible highly prolific phenotype these two breeds, genome-wide association (GWAS) followed by complementary functional analyses performed. Highly ewes (cases) normal (controls) from each breed genotyped...
The diversity of populations in domestic species offers great opportunities to study genome response selection. recently published Sheep HapMap dataset is a example characterization the world wide genetic sheep. In this study, we re-analyzed identify selection signatures worldwide sheep populations. Compared previous analyses, made use statistical methods that (i) take account hierarchical structure populations, (ii) make linkage disequilibrium information and (iii) focus specifically on...
Since goat was domesticated 10,000 years ago, many factors have contributed to the differentiation of breeds and these are classified mainly into two types: (i) adaptation different breeding systems and/or purposes (ii) environments. As a result, approximately 600 developed worldwide; they differ considerably from one another in terms phenotypic characteristics adapted wide range climatic conditions. In this work, we analyzed AdaptMap dataset, which is composed data more than 3000 animals...
Comparative genomics studies are central in identifying the coding and non-coding elements associated with complex traits, functional annotation of genomes is a critical step to decipher genotype-to-phenotype relationships livestock animals. As part Functional Annotation Animal Genomes (FAANG) action, FR-AgENCODE project aimed create reference maps domesticated animals by profiling landscape transcription (RNA-seq), chromatin accessibility (ATAC-seq) conformation (Hi-C) species representing...
One of the approaches to detect genetics variants affecting fitness traits is identify their surrounding genomic signatures past selection. With established methods for detecting selection and current future availability large datasets, such studies should have power not only these but also infer selective histories. Domesticated animals offer a powerful model as they adapted rapidly environmental human-mediated constraints in relatively short time. We investigated this question by studying...
In recent years, the use of genomic information in livestock species for genetic improvement, association studies and many other fields has become routine. order to accommodate different market requirements terms genotyping cost, manufacturers single nucleotide polymorphism (SNP) arrays, private companies international consortia have developed a large number arrays with content SNP density. The currently available differs among species: ranging from one goats more than ten cattle, is...
Mastitis is an infectious disease mainly caused by bacteria invading the mammary gland. Genetic control of susceptibility to mastitis has been widely evidenced in dairy ruminants, but genetic basis and underlying mechanisms are still largely unknown. We describe discovery, fine mapping functional characterization a variant associated with elevated milk leukocytes count, or SCC, as proxy for mastitis. After implementing genome-wide association studies, we identified major QTL SCC on ovine...
Abstract The quantity of milk and fat proteins are particularly important traits in dairy livestock. However, little is known about the regions genome that influence these goats. We conducted a wide association study French goats identified 109 associated with traits. For major region on chromosome 14 closely content, Diacylglycerol O-Acyltransferase 1 ( DGAT1 ) gene turned out to be functional positional candidate gene. caprine reference sequence this was completed 29 polymorphisms were...
Abstract This study presents a dynamic characterization of the sheep milk transcriptome aiming at achieving better understanding lactating mammary gland. Transcriptome sequencing (RNA-seq) was performed on total RNA extracted from somatic cells ewes days 10, 50, 120 and 150 after lambing. The experiment in Spanish Churra Assaf breeds, which differ their production traits. Nearly 67% annotated genes reference genome (Oar_v3.1) were expressed ovine cells. For two breeds across four lactation...
IGF binding protein-4 (IGFBP-4) proteolytic degradation is a common feature of preovulatory follicles from human, ovine, bovine, porcine, and equine ovary. In all these species, the protease zinc-dependent metalloprotease its ability to degrade IGFBP-4 dependent. The human intrafollicular IGFBP-4-degrading has recently been identified as pregnancy-associated plasma protein-A (PAPP-A). aim this study was investigate whether PAPP-A also involved in expression mRNA bovine porcine granulosa...
Ovarian folliculogenesis corresponds to the development of follicles leading either ovulation or degeneration, this latter process being called atresia. Even if atresia involves apoptosis, its mechanism is not well understood. The objective study was analyze global gene expression in pig granulosa cells ovarian during transcriptome analysis performed on a 9,216 cDNA microarray identify networks and candidate genes involved follicular We found 1,684 significantly regulated be differentially...
The composition and structure of fleece variation observed in mammals is a consequence strong selective pressure for fiber production after domestication. In sheep, discriminates ancestral species carrying long hairy from modern domestic sheep (Ovis aries) owning short woolly fleece. Here, we report that the “woolly” allele results insertion an antisense EIF2S2 retrogene (called asEIF2S2) into 3′ UTR IRF2BP2 gene leading to abnormal transcript. We provide evidence this chimeric...
Small ruminants are suited to a wide variety of habitats and thus represent promising study models for identifying genes underlying adaptations. Here, we considered local Mediterranean breeds goats (n = 17) sheep 25) from Italy, France Spain. Based on historical archives, selected the potentially most linked territory defined their original cradle (i.e., geographical area in which breed has emerged), including transhumant pastoral areas. We then used programs PCAdapt LFMM identify signatures...
Successful achievement of early folliculogenesis is crucial for female reproductive function. The process finely regulated by cell-cell interactions and the coordinated expression genes in both oocyte granulosa cells. Despite many studies, little known about cell-specific gene driving folliculogenesis. very small size these follicles mixture types within developing ovary make experimental study isolated follicular components difficult. recently developed laser capture microdissection (LCM)...
Summary The recent availability of a genome‐wide SNP array for the goat genome dramatically increases power to investigate aspects genetic diversity and conduct association studies in this important domestic species. We collected analysed genotypes from 52 088 SNPs B oer, C ashmere R angeland goats that had both polled horned individuals. Principal components analysis revealed clear division between animals each population, model‐based clustering successfully detected evidence admixture...