A5058475288- Genetic and phenotypic traits in livestock
- Rabbits: Nutrition, Reproduction, Health
- Animal Nutrition and Physiology
- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- Genetic Mapping and Diversity in Plants and Animals
- Livestock and Poultry Management
- Ruminant Nutrition and Digestive Physiology
- Agricultural Systems and Practices
- Reproductive Physiology in Livestock
- Ovarian function and disorders
- Agriculture Sustainability and Environmental Impact
- Agriculture and Rural Development Research
- Plant Taxonomy and Phylogenetics
- Epigenetics and DNA Methylation
- Silkworms and Sericulture Research
- Food Industry and Aquatic Biology
- Metabolism and Genetic Disorders
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Genetic diversity and population structure
- Pasture and Agricultural Systems
- Insect Utilization and Effects
- Molecular Biology Techniques and Applications
- Genetics and Plant Breeding
Génétique Physiologie et Systèmes d'Elevage
2014-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Université de Toulouse
2014-2023
École Nationale Vétérinaire de Toulouse
2014-2022
Institut National Polytechnique de Toulouse
2014-2020
École Nationale Supérieure Agronomique de Toulouse
2014-2015
Département Biologie et Amélioration des Plantes
2008-2013
Laboratoire de Génétique Cellulaire
2009-2013
Université de Tours
2008-2012
Centre National de la Recherche Scientifique
2008-2012
High between-animal variability in the number of embryos produced by multiple ovulation and embryo transfer (MOET) ovum pick-up vitro production (OPU–IVP) methods remains a major limit to development biotechnologies cattle. The measurement anti-Müllerian hormone (AMH) endocrine concentrations cows can help predict their follicular ovulatory responses gonadotrophin treatment. present study aimed provide practical information for simple prognostic method based on AMH Holstein cows. Accurate...
Prolific sheep have proven to be a valuable model identify genes and mutations implicated in female fertility. In the Lacaune breed, large variation litter size is genetically determined by segregation of fecundity major gene influencing ovulation rate, named FecL its prolific allele FecLL. Our previous work localized on chromosome 11 within locus 1.1 Mb encompassing 20 genes. With aim gene, we developed high throughput sequencing strategy long-range PCR fragments spanning FecLL carrier...
Abstract Recombination is a complex biological process that results from cascade of multiple events during meiosis. Understanding the genetic determinism recombination can help to understand if and how these are interacting. To tackle this question, we studied patterns in sheep, using approaches data sets. We constructed male maps dairy breed south France (the Lacaune breed) at fine scale by combining meiotic rates large pedigree genotyped with 50K SNP array historical sample unrelated...
Improvement of feed efficiency can be achieved by genetic selection directly on to BW gain ratio or for alternative traits. In the present study, 2 different traits were explored in growing rabbit and their heritability correlations with recorded between weaning (30 d) 63 d age: i) residual intake (RFI), select animals having low ad libitum independently from production level, ii) ADG under restricted feeding (ADGR; a restriction level 80% compared control group), high growth rate despite...
To get insights into selection criteria for feed efficiency, 2 rabbit lines have been created: the ConsoResidual line was selected residual intake (RFI) with ad libitum feeding and ADGrestrict ADG under restricted (–20% of voluntary intake). The first objective this study to evaluate, after 9 generations selection, direct correlated responses on production traits in recorded during growth. Second, applying conditions used both plus control unselected (generation 0, G0) a × 3 factorial trial,...
The composition and structure of fleece variation observed in mammals is a consequence strong selective pressure for fiber production after domestication. In sheep, discriminates ancestral species carrying long hairy from modern domestic sheep (Ovis aries) owning short woolly fleece. Here, we report that the “woolly” allele results insertion an antisense EIF2S2 retrogene (called asEIF2S2) into 3′ UTR IRF2BP2 gene leading to abnormal transcript. We provide evidence this chimeric...
In the Lacaune sheep population, two major loci influencing ovulation rate are segregating: FecX and FecL. The FecX(L) mutation is a non-conservative substitution (p.Cys53Tyr) in BMP15 that prevents processing of protein. Using statistical approach, FecL has been shown to be an autosomal gene. A full genome scan localized locus on chromosome 11. Fine mapping reduced interval containing markers BM17132 FAM117A, corresponding synteny block 1.1 megabases human 17, which encompasses 20 genes....
The search for the genetic determinism of prolificacy variability in sheep has evidenced several major mutations genes playing a crucial role control ovulation rate. In Noire du Velay (NV) population, recent study segregation such mutation named FecLL. However, based on litter size (LS) records FecLL non-carrier ewes, second was suspected this population. order to identify mutation, we have combined case/control genome-wide association with ovine 50k SNP chip genotyping, whole genome...
Abstract Background The current cattle reference genome assembly, a pseudo-linear sequence produced using sequences from single Hereford cow, represent limit when performing genetic studies, especially investigating the whole spectrum of variations within species. Detecting structural (SVs) poses significant challenges relying solely on conventional methods short or long-read mapping to bovine assembly. Results In this study, we used long-reads (LR) and bioinformatic tools construct...
A prolific allele named FecLL is known to segregate in the meat breed of French Lacaune sheep on basis ovulation rate record. To gain more knowledge about physiological effects FecLL, ewes homozygous for (L/L) were compared wild-type (+/+) ovarian phenotype and reproductive endocrine profiles. At level, increased L/L was associated with an number antral follicles greater than 3 mm preovulatory being, average, 1 smaller. Intrafollicular estradiol testosterone concentrations not significantly...
In France, about 95% of the fatty liver production comes from mule ducks, an infertile hybrid cross between female common ducks (Anas platyrhynchos) and Muscovy drakes (Cairina moschata). As a hybrid, genetic improvement performance is achieved by selection parental populations. Feed represents two-thirds total costs duck production; thus, breeders' main concern to improve birds' feed efficiency without impairing their capacity be overfed after growing period. To obtain insight into this...
A divergent selection experiment of Muscovy sires based on the residual feed intake (RFI) their male mule progeny was initiated in 2009. Using electronic feeders, aim this study to establish whether 3 generations for RFI had an impact feeding behavior traits and general behavior, examine its effect liver meat quality. Eighty ducks, issued from 8 drakes per line with extreme RFI, were tested a pen equipped 4 feeders. Feeding behaviors recorded 7 wk after hatching under ad libitum conditions....
Feed efficiency is a major production trait in animal genetic breeding schemes. To further investigate the control of feed rabbits, we performed genome-wide association study (GWAS) for growth and on 679 rabbits genotyped with Affimetrix Axiom Rabbit 200K Genotyping Array. After quality control, 127 847 single-nucleotide polymorphisms (SNP) were retained analyses. The GWAS using GEMMA software, applying mixed univariate model linear regression each SNP allele. traits analysed weight at...
With the development of automatic self-feeders and electronic identification, automated, repeated measurements individual feed intake (FI) BW are becoming available in more species. Consequently, genetic models for longitudinal data need to be applied study FI or related traits. To handle this type data, several flexible mixed-model approaches exist such as character process (CPr), structured antedependence (SAD), random regression (RR) models. The objective was compare how these different...
For many decades, prolificacy has been selected in meat sheep breeds as a polygenic trait but with limited genetic gain. However, the discovery of major genes affecting changed way selection for some ovine implementing gene-assisted French Lacaune and Grivette breeds, or Spanish Rasa Aragonesa breed. Based on statistical analysis litter size parameters from 34 populations, we suspected segregation mutation gene Noire du Velay Mouton Vendéen exhibiting very high variability size. After...
To get insights into selection criteria for feed efficiency, 2 rabbit lines have been created: the ConsoResidual line was selected residual intake (RFI) with ad libitum feeding and ADGrestrict ADG under restricted feeding. The aim of present study to evaluate impact on carcass meat quality genetic selections. This comparison performed using different strategies corresponding design. Carcass traits were recorded 3 (ConsoResidual, ADGrestrict, an unselected control [generation 0 {G0}]) in...
The aim of this experiment was to evaluate the significance neonatal environment on feed efficiency. For that purpose, rabbits from a line selected for residual intake (RFI) during 10 generations (G10 kits) were cross-fostered with non-selected control does (i.e., G0 line), and reciprocally. In parallel, sibs fostered by mothers their original line. Nine hundred animals raised in individual (N = 456) or collective 320) cages. Traits analysed study body weight at 32 days 63 days, average...
Two rabbit lines have been created to result in better feed efficiency: the ConsoResidual line was selected for a lower residual intake under ad libitum feeding, and ADGrestrict higher ADG restricted feeding (-20% of libitum). The present study aimed analyze digestion excretion N minerals from 29 63 d age these 2 compared with an unselected control (G0) levels (ad or restricted). had greater digestibility G0 (+1.3% OM N; < 0.05), intermediate values. There no genetic effect on P...
Recent studies showed that epigenetic marks, including DNA methylation, influence production and adaptive traits in plants animals. So far, most dealing with genetics epigenetics considered methylation sites independently. However, the genetic basis of global rate (GDMR) remains unknown. The main objective present study was to investigate determinism GDMR sheep. experiment conducted on 1,047 Romane sheep allocated into 10 half-sib families. After weaning, all lambs were phenotyped for blood...