A5028146288- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Helminth infection and control
- Milk Quality and Mastitis in Dairy Cows
- Cancer-related molecular mechanisms research
- Genetic diversity and population structure
- Effects of Environmental Stressors on Livestock
- Animal Genetics and Reproduction
- Meat and Animal Product Quality
- Molecular Biology Techniques and Applications
- Identification and Quantification in Food
- Wheat and Barley Genetics and Pathology
- Ruminant Nutrition and Digestive Physiology
- Probiotics and Fermented Foods
- Livestock and Poultry Management
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Prion Diseases and Protein Misfolding
- Gut microbiota and health
- Birth, Development, and Health
- Fatty Acid Research and Health
- RNA modifications and cancer
- Parasitic Infections and Diagnostics
- Neurological diseases and metabolism
- Animal Behavior and Welfare Studies
Universidad de León
2016-2025
Universidad de León
2020-2024
University College Dublin
2022
Hospital Universitario 12 De Octubre
2022
Hospital Clínic de Barcelona
2019
Universitat Jaume I
2014
Molina Center for Energy and the Environment
2012
Roslin Institute
2007-2009
University of Edinburgh
2008-2009
Parco Tecnologico Padano
2008
The variability of mtDNA was analysed in local sheep breeds reared throughout Turkey, for which a fragment the D-loop region and complete cytochrome b were sequenced. Phylogenetic analyses performed independently Cyt gene revealed three clearly separated clusters indicating major maternal lineages, two had been previously described as types B A. new type, C, present all showed considerable variability. Divergence time obtained on basis estimated to be around 160 000–170 000 years ago...
In this study, we used the Illumina OvineSNP50 BeadChip to conduct a genome-wide association (GWA) analysis for milk production traits in dairy sheep by analyzing commercial population of Spanish Churra sheep. The studied consisted total 1,681 ewes belonging 16 half-sib families with available records yield (MY), protein and fat yields (PY FY) contents (PP FP). most significant identified reached experiment-wise significance PP FP was located on chromosome 3 (OAR3). These results confirm...
Abstract This study presents a dynamic characterization of the sheep milk transcriptome aiming at achieving better understanding lactating mammary gland. Transcriptome sequencing (RNA-seq) was performed on total RNA extracted from somatic cells ewes days 10, 50, 120 and 150 after lambing. The experiment in Spanish Churra Assaf breeds, which differ their production traits. Nearly 67% annotated genes reference genome (Oar_v3.1) were expressed ovine cells. For two breeds across four lactation...
In cattle, the gene coding for melanocortin receptor 1 (MC1R) is known to be main regulator of switch between two coat colour pigments: eumelanin (black pigment) and phaeomelanin (red pigment). Some breeds, such as Charolais Simmental, exhibit a lightening original pigment over whole body. The dilution mutation in (Dc) responsible white this breed. Using an F2-Backcross × Holstein population which includes animals with both backgrounds, we present linkage mapping study locus. A crossbred was...
A genome scan to detect QTL influencing growth and carcass-related traits was conducted in a Charolais x Holstein crossbred cattle population. Phenotypic measurements related carcass were made on the 235 second-generation males of this herd (F2 reciprocal backcrosses), which born 4 consecutive annual cohorts. Traits measured vivo birth dimensions, rates, ultrasound fat muscle depth. The animals slaughtered near target BW 550 kg, wide range postmortem measured: visual assessment conformation...
Abstract Background Genomic technologies, such as high-throughput genotyping based on SNP arrays, have great potential to decipher the genetic architecture of complex traits and provide background information concerning genome structure in domestic animals, including extent linkage disequilibrium (LD) haplotype blocks. The objective this study was estimate LD, population evolution (past effective size) level inbreeding Spanish Churra sheep. Results A total 43,784 SNPs distributed ovine...
Persistence of gastrointestinal nematode (GIN) infection and the related control methods have major impacts on sheep industry worldwide. Based information generated with Illumina OvineSNP50 BeadChip (50 K chip), this study aims at confirming quantitative trait loci (QTL) that were previously identified by microsatellite-based genome scans identifying new QTL allelic variants are associated indicator traits parasite resistance in adult sheep. We used a commercial half-sib population 518...
In Europe, especially in Mediterranean areas, the sheep has been traditionally exploited as a dual purpose species, with income from both meat and milk. Modernization of husbandry methods establishment breeding schemes focused on milk production have led to development "dairy breeds." This study investigated selective sweeps specifically related dairy by searching for regions commonly identified different European breeds. With this aim, genotypes 44,545 SNP markers covering autosomes were...
Abstract Background Livestock populations are under constant selective pressure for higher productivity levels different purposes. This results in the selection of animals with unique adaptive and production traits. The study genomic regions associated these characteristics has potential to improve biological knowledge regarding process how it is connected resilience, which ability an animal adapt stress or imbalance homeostasis. Sheep a species that been subjected several natural artificial...
Feed efficiency (FE) is an essential trait in livestock species because of the constant demand to increase productivity and sustainability production systems. A better understanding biological mechanisms associated with FEs might help improve estimation selection superior animals. In this work, differentially methylated regions (DMRs) were identified via genome-wide bisulfite sequencing (GWBS) by comparing DNA methylation profiles milk somatic cells from dairy ewes that divergent terms...
In addition to its potential contribution improving animal welfare, the study of genetics cattle behavior may provide more general insights into genetic control such complex traits. We carried out a genome scan in Holstein × Charolais cross population identify quantitative trait loci (QTL) influencing temperament-related Individuals belonging second-generation this (F2 and backcross individuals) were subjected 2 behavioral tests. The flight from feeder (FF) test measured distance at which...
Summary A whole‐genome scan was carried out to detect quantitative trait loci (QTL) affecting sensory, organoleptic, physical and chemical properties of meat. The study used phenotypic data from 235 second‐generation cross‐bred bull calves a Charolais × Holstein experimental population. Loin muscle samples were evaluated for yield force, intramuscular fat nitrogen contents, myofibrillar fragmentation index, haem pigment concentration, moisture content pH at 24 h postmortem. sensory...
The identification of genetic variation underlying desired phenotypes is one the main challenges current livestock research. High-throughput transcriptome sequencing (RNA-Seq) offers new opportunities for detection variants (SNPs and short indels) in different tissues species. In this study, we used RNA-Seq on Milk Sheep Somatic Cells (MSCs) with goal characterizing within coding regions milk Churra Assaf sheep, two common dairy sheep breeds farmed Spain.A total 216,637 were detected MSCs...
Abstract BACKGROUND We aimed to derive and externally validate a 0/2-h algorithm using the high-sensitivity cardiac troponin I (hs-cTnI)-Access assay. METHODS enrolled patients presenting emergency department with symptoms suggestive of acute myocardial infarction (AMI) in 2 prospective diagnostic studies central adjudication. Two independent cardiologists adjudicated final diagnosis, including all available medical information imaging. hs-cTnI-Access concentrations were measured at...
Abstract This work aimed to use 16S ribosomal RNA sequencing with the Illumina MiSeq platform describe milk microbiota from 50 healthy Assaf ewes. The global observed microbial community for clinically samples analysed was complex and showed a vast diversity. core of sheep includes five genera: Staphylococcus , Lactobacillus Corynebacterium Streptococcus Escherichia/Shigella . Although there are some differences, these genera common pattern other species, especially dairy cows. composition...
Estimating feed efficiency (FE) in dairy sheep is challenging due to the high cost of systems that measure individual intake. Identifying proxies can serve as effective predictors FE could make it possible introduce into breeding programs. Here, 39 Assaf ewes first lactation were evaluated regarding their by 2 metrics, residual intake (RFI) and conversion ratio (FCR). The classified high, medium low groups for each metric. Milk samples subjected untargeted metabolomics analysis. complete...
Abstract Background For ruminants reared on grazing systems, gastrointestinal nematode (GIN) parasite infections represent the class of diseases with greatest impact animal health and productivity. Among many possible strategies for controlling GIN infection, enhancement host resistance through selection resistant animals has been suggested by authors. Because difficulty routinely collecting phenotypic indicators resistance, information derived from molecular markers may be used to improve...
Improvement of milk production traits in dairy sheep is required to increase the competitiveness industry and maintain high quality cheese regions Mediterranean countries with less favourable conditions. Additional improvement over classical selection could be reached if genes significant effects on relevant were specifically targeted by selection. However, so far, few studies have been undertaken detect quantitative trait loci (QTL) sheep. In this study, we present a complete genome scan...
Summary The objectives of this work were to assess the mt DNA diversity B olivian S outh A merican camelid ( SAC ) populations and shed light on evolutionary relationships between camelids other s. We have analysed two different regions: complete coding region MT ‐ CYB gene 513 bp D ‐loop region. sampled included llamas, alpacas vicunas, C hilean guanacos. High levels genetic observed in studied populations. In general, was more variable than ‐loop. On a species level, vicunas showed lowest...
Because ewe milk is principally used for cheese making, its quality related to content of total solids and the way in which constituents influence yield determine technological organoleptic characteristics dairy products. Therefore, an in-depth knowledge expression levels genes influencing cheese-related traits essential. In present study, transcriptome data set 2 sheep breeds, Assaf Spanish Churra, was evaluate 77 transcripts traits. For comparison between both we selected RNA sequencing...
The effects of glucocorticoids on the regulation rat liver S-adenosylmethionine synthetase were studied in vivo and two culture systems. Livers from adrenalectomized animals examined for enzyme activity, immunoreactive protein, messenger RNA (mRNA) content. All three parameters showed a similar trend, i.e. they decreased 3-fold after adrenalectomy increased over control values upon triamcinolone replacement. These results suggested that glucocorticoid hepatic was mediated at mRNA level....
Summary In this study, the availability of Ovine HD SNP BeadChip ( ‐chip) and development an imputation strategy provided opportunity to further investigate extent linkage disequilibrium LD ) at short distances in genome Spanish Churra dairy sheep breed. A population 1686 animals, including 16 rams their half‐sib daughters, previously genotyped for 50K‐chip, was imputed ‐chip density based on a reference 335 individuals. After assessing accuracy beagle v4.0 (0.922) fimpute v2.2 (0.921) using...