Patrick Badertscher
A5072029348- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Pressure and Hypertension Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Heart Rate Variability and Autonomic Control
- Takotsubo Cardiomyopathy and Associated Phenomena
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Aortic aneurysm repair treatments
- Advanced MRI Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Sarcoidosis and Beryllium Toxicity Research
University Hospital of Basel
2016-2025
University of Basel
2017-2025
Universitäre Psychiatrische Kliniken Basel
2025
Cardiovascular Institute Hospital
2018-2024
Hospital Base
2018-2024
University Hospital of Bern
2024
University of Bern
2024
Medical University of South Carolina
2020-2023
Daiichi-Sankyo (South Korea)
2020
University Hospital Innsbruck
2020
Perioperative myocardial injury (PMI) seems to be a contributor mortality after noncardiac surgery. Because the vast majority of PMIs are asymptomatic, PMI usually is missed in absence systematic screening. We performed prospective diagnostic study enrolling consecutive patients undergoing surgery who had planned postoperative stay ≥24 hours and were considered at increased cardiovascular risk. All received screening using serial measurements high-sensitivity cardiac troponin T clinical...
Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful determining probability and subsequent 30-day outcomes.
Acute aortic syndromes (AASs) are rare and severe cardiovascular emergencies with unspecific symptoms. For AASs, both misdiagnosis overtesting key concerns, standardized diagnostic strategies may help physicians to balance these risks. D-dimer (DD) is highly sensitive for AAS but inadequate as a stand-alone test. Integration of pretest probability assessment DD testing feasible, the safety efficiency such strategy currently unknown.In multicenter prospective observational study involving 6...
Background: High-sensitivity cardiac troponin assays enable myocardial infarction to be ruled out earlier, but the optimal approach is uncertain. We compared European Society of Cardiology rule-out pathway with a that incorporates lower concentrations risk stratify patients. Methods: Patients suspected acute coronary syndrome (n=1218) underwent high-sensitivity I measurement at presentation and 3 6 or 12 hours. (<99th centile hours if symptoms <6 hours) developed in High-STEACS study...
Variations in cardiac troponin concentrations by age, sex, and time between samples patients with suspected myocardial infarction are not currently accounted for diagnostic approaches. We aimed to combine these variables through machine learning improve the assessment of risk individual patients.A algorithm (myocardial-ischemic-injury-index [MI3]) incorporating paired high-sensitivity I concentrations, was trained on 3013 tested 7998 infarction. MI3 uses gradient boosting compute a value...
Background: Four strategies for very early rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (hs-cTnI) have been identified. It remains unclear which strategy is most attractive clinical application. Methods: We prospectively enrolled unselected patients presenting to the emergency department with symptoms suggestive infarction. The final diagnosis was adjudicated by 2 independent cardiologists. Hs-cTnI levels were measured at presentation and after 1 hour in...
The European Society of Cardiology recommends a 0/1-hour algorithm for rapid rule-out and rule-in non-ST-segment elevation myocardial infarction using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective renal function. Because patients with dysfunction (RD) frequently present increased hs-cTn even in the absence infarction, concern has been raised regarding performance RD. In prospective multicenter diagnostic study enrolling unselected presenting suspected to emergency...
Abstract BACKGROUND Clinical performance of the novel high-sensitivity cardiac troponin I (Siemens-hs-cTnI-Centaur) assay is unknown. We aimed to clinically validate Siemens-hs-cTnI-Centaur and develop 0/1-h 0/2-h algorithms. METHODS enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists including all clinical information twice: first, using serial hs-cTnT...
Until now, high-sensitivity cardiac troponin (hs-cTn) assays were mainly developed for large central laboratory platforms. This study aimed to assess the clinical performance of a point-of-care (POC)-hs-cTnI assay in patients with suspected myocardial infarction (MI). enrolled presenting emergency department symptoms suggestive MI. Two cardiologists centrally adjudicated final diagnosis using all data including imaging. The primary objective was directly compare diagnostic accuracy...
We aimed to evaluate the impact of age on performance European Society Cardiology (ESC) 0/1h-algorithms and derive externally validate alternative cut-offs specific older patients.We prospectively enrolled patients presenting emergency department (ED) with symptoms suggestive acute myocardial infarction in three large diagnostic studies. Final diagnoses were adjudicated by two independent cardiologists. High-sensitivity cardiac troponin (hs-cTn) T I concentrations measured at presentation...
It is currently unknown whether the uniform (universal clinical practice for more than 2 decades) or sex-specific cutoff levels are preferable when using high-sensitivity cardiac troponin T (hs-cTnT) in diagnosis of acute myocardial infarction (AMI).To improve management suspected AMI women by exploring vs hs-cTnT.In an ongoing prospective, diagnostic, multicenter study conducted at 9 emergency departments, present evaluated patients enrolled from April 21, 2006, through June 5, 2013. The...
The aim of this study was to validate the clinical performance Beckman Access high-sensitivity cardiac troponin I (hs-cTnI) assay.We enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists all information including imaging twice: first, using serial hs-cTnT (Elecsys, primary analysis), and second, hs-cTnI (Architect, secondary analysis) measurements in addition...
Pulsed-field ablation (PFA) has emerged as a novel treatment technology for patients with atrial fibrillation (AF). Cryoballoon (CB) is the most frequently used single shot technology. A direct comparison to CB system lacking. We aimed compare pulmonary vein isolation (PVI) using PFA vs. regarding efficiency, safety, myocardial injury, and outcomes.
Non-pulmonary vein (PV) ablation targets such as posterior wall isolation (PWI) have been tested in patients with persistent atrial fibrillation (AF). Pulsed-field (PFA) offers a novel technology possibly able to overcome the obstacles of incomplete PWI and concerns damage adjacent structures compared thermal energy sources. Our aim was assess procedural characteristics, safety, mid-term outcomes undergoing using PFA clinical setting.
Abstract Ventricular tachycardia (VT), and its occurrence, is still one of the main reasons for sudden cardiac death and, therefore, increased mortality morbidity foremost in patients with structural heart [Kahle A-K, Jungen C, Alken F-A, Scherschel K, Willems S, Pürerfellner H et al. Management ventricular ischaemic cardiomyopathy: contemporary armamentarium. Europace 2022;24:538–51]. Catheter ablation has become a safe effective treatment option recurrent VT [Cronin EM, Bogun FM, Maury P,...
Catheter ablation for atrial fibrillation (AF) including pulmonary vein isolation and possibly further substrate is the most common electrophysiological procedure. Severe complications are uncommon, but their detailed assessment in a large worldwide cohort lacking. The aim of this study was to determine incidence periprocedural severe provide characterization diagnostic evaluation management these patients undergoing AF ablation. Individual patient data were collected from 23 centers...
Background: Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological analytical limitations thereby increase diagnostic accuracy for acute myocardial infarction with a single blood draw. We aimed to evaluate the performance combinations high-sensitivity (hs) cTnI hs-cTnT early diagnosis infarction. Methods: The combining hs-cTnI (Architect, Abbott) (Elecsys, Roche) concentrations (sum, product, ratio, combination...