A5053831485- Molecular Junctions and Nanostructures
- Terahertz technology and applications
- Photonic and Optical Devices
- Graphene research and applications
- Insect and Pesticide Research
- Fullerene Chemistry and Applications
- Spectroscopy and Laser Applications
- Synthesis and Biological Evaluation
- Fungal Plant Pathogen Control
- Neurobiology and Insect Physiology Research
- Irrigation Practices and Water Management
- Synthesis and biological activity
- Quantum and electron transport phenomena
- interferon and immune responses
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Advanced Chemical Sensor Technologies
- Dark Matter and Cosmic Phenomena
- Insect Pest Control Strategies
- Plant Physiology and Cultivation Studies
- Acoustic Wave Resonator Technologies
- Surface and Thin Film Phenomena
- Computational Drug Discovery Methods
University of Shanghai for Science and Technology
2011-2025
Shandong University
2023-2025
The University of Tokyo
2016-2024
Shanghai Institute of Microsystem and Information Technology
2023-2024
Chinese Academy of Sciences
2023-2024
China Agricultural University
2015-2022
East China University of Science and Technology
2021
National Institute of Quality
2019-2020
North Carolina State University
2009-2019
Tokyo University of Science
2018
Variations in cardiac troponin concentrations by age, sex, and time between samples patients with suspected myocardial infarction are not currently accounted for diagnostic approaches. We aimed to combine these variables through machine learning improve the assessment of risk individual patients.A algorithm (myocardial-ischemic-injury-index [MI3]) incorporating paired high-sensitivity I concentrations, was trained on 3013 tested 7998 infarction. MI3 uses gradient boosting compute a value...
Abstract Drug resistance is a looming threat to global health security, undermining the effectiveness of current treatments and increasing treatment failures. To address this challenge, it necessary explore innovative strategies by identifying new binding mechanisms targeting previously undeveloped therapeutic avenues. This paper reviewed potential leveraging domains combat drug proposes range methodologies accurately identify those specific targets. There also an extensive review challenges...
In view of the gradual rejuvenation and acceleration lumbar spondylosis, a wearable powered exoskeleton based on 6-SPU/SP parallel mechanism is designed rehabilitation treatment method forward flexion/extension, left/right lateral flexion rotation. First, changes in human muscles are analyzed biomechanics, then prototype design implemented, including mechanical design, hardware module design. Finally, simulation experiment muscle force output sensitivity test resistive mode conducted. The...
Succinate dehydrogenase (SDH) is one of the most important molecular targets for development new fungicides. Carboxamide fungicides are a class SDH inhibitors widely used to inhibit highly destructive plant pathogens. Although cases resistance have been found in fungal pathogens due unrestricted use recent years, there still demand compounds with improved fungicidal activity. Therefore, series ester were designed investigate potential novel antifungal molecules. First, activity different...
By using terahertz time-domain spectroscopy, the absorption spectra of seven anti-diabetic pills have been investigated. For gliquidone, glipizide, gliclazide, and glimepiride, an obvious resonance peak is found at 1.37 THz. Furthermore, to overcome limit density functional theory that can analyze normal mode frequencies ground state organic material, we also present a method relies on pharmacophore recognition, from which obtain THz be attributed vibration sulfonylurea group. The results...
We report the first measurement of an angular correlation parameter in neutron $\ensuremath{\beta}$ decay using polarized ultracold neutrons (UCN). utilize UCN with energies below about 200 neV, which we guide and store for $\ensuremath{\sim}30\text{ }\text{ }\mathrm{s}$ a Cu volume. The interaction magnetic dipole moment static 7 T field external to volume provides 420 neV potential energy barrier spin state parallel field, polarizing before they pass through adiabatic fast passage flipper...
Odorant-binding protein (OBP) is a potential target for developing insect behavior control agents due to its properties in transporting semiochemicals. In this study, 12 novel jasmonic acid (JA) derivatives were rationally designed and synthesized based on the binding features between Acyrthosiphon pisum OBP3 (ApisOBP3) compound D1 [(E)-3,7-dimethylocta-2,6-dien-1-yl 2-(3-oxo-2-pentylcyclopentyl)acetate] with affinity (Kd) of 26.79 μM. Most JA displayed better affinities than (Kd = 1-26 μM)....
Abstract Diverse molecular fragments have generally facilitated the development of drug discovery. Heterocyclic moieties could be found in most active ingredients, especially chemical pesticides. Based on our previously reported 3,3,3‐Benzyl trifluoropropionate compounds which are excellent insecticidal and fungicidal activity, we designed synthesized 13 Methyl Ester (HME) compounds, HME01 ‐ HME13 , comprising heterocyclic parts. Four insect species four plant pathogens were employed...
Light molecules such as H2O are the systems in which we can have access to quantum mechanical information on their constituent atoms. Here, investigated electron transport through H2O@C60 single molecule transistors (SMTs). The SMTs exhibit Coulomb stability diagrams that show multiple tunneling-induced excited states below 30 meV. Furthermore, performed terahertz (THz) photocurrent spectroscopy and confirmed same excitations. From comparison between experiment theory, excitations observed...
Upon the discovery of superatom states in endohedral metallofullerenes (EMFs), properties have become attractive, because ultrafast motion trapped atom modifies charge distribution fullerene cage. However, observation cage is very challenging, since dynamical processes take place terahertz (THz) frequency range a picometer region. Here, we report on THz spectroscopy single Ce@C82 EMF molecules by using molecule transistor geometry. Due to vibron-assisted tunneling process, two broad...