A5071471535- Acute Myocardial Infarction Research
- Pharmacogenetics and Drug Metabolism
- Cardiac Imaging and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug Transport and Resistance Mechanisms
- Cardiac electrophysiology and arrhythmias
- Pregnancy and preeclampsia studies
- Coronary Interventions and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Effects of Exercise
- Sarcoidosis and Beryllium Toxicity Research
- Atrial Fibrillation Management and Outcomes
- Sepsis Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Birth, Development, and Health
- Cardiovascular Function and Risk Factors
- Machine Learning in Healthcare
- Gestational Diabetes Research and Management
Maastricht University Medical Centre
2015-2024
Maastricht University
2015-2024
University Medical Center
2014-2022
Ild Care Foundation
2010-2021
Cardiovascular Institute Hospital
2017
University Hospital of Basel
2017
University of Basel
2017
Radboud University Nijmegen
2017
Research Institute for Farm Animal Biology (FBN)
2017
Catharina Ziekenhuis
2017
Matrix γ-carboxyglutamate (Gla) protein (MGP) is an important local inhibitor of vascular calcification, which can undergo two post-translational modifications: vitamin K-dependent γ-glutamate carboxylation and serine phosphorylation. While thought to have effects upon binding calcium-ions, phosphorylation supposed affect the cellular release MGP. Since both modifications be exerted incompletely, various MGP species detected in circulation. levels were measured with commercially available...
Cyclodextrins (CyDs) are cyclic oligosaccharides, containing a minimum of six D-(+)-glycopyranose units attached by α-1, 4-linkages produced the action cyclodextrin-trans-glycosidase enzyme on medium starch. CyDs somewhat cone-shaped. The outside is hydrophilic and inside cavity hydrophobic in character. If molecule fits entirely or at least partially into cavity, an inclusion complex may be formed. In general, molecules, rather than ones, have higher affinity to CyD aqueous solutions....
Observational data suggest a link between menaquinone (MK, vitamin K2) intake and cardiovascular (CV) health. However, MK intervention trials with vascular endpoints are lacking. We investigated long-term effects of MK-7 (180 µg MenaQ7/day) supplementation on arterial stiffness in double-blind, placebo-controlled trial. Healthy postmenopausal women (n=244) received either placebo (n=124) or (n=120) for three years. Indices local carotid (intima-media thickness IMT, Diameter end-diastole...
Patients with sepsis who present to an emergency department (ED) have highly variable underlying disease severity, and can be categorized from low high risk. Development of a risk stratification tool for these patients is important appropriate triage early treatment. The aim this study was develop machine learning models predicting 31-day mortality in presenting the ED compare internal medicine physicians clinical scores.A single-center, retrospective cohort conducted amongst 1,344...
Responsiveness to tumour necrosis factor (TNF) inhibitors has been associated with the TNF-α G-308A polymorphism in rheumatoid arthritis. The aim of this study was examine association between presence and response TNF patients refractory sarcoidosis. Patients (n=111) who started TNF-inhibitor treatment (76 infliximab, 35 adalimumab) were followed for at least 1 year. main symptoms these fatigue (n=100, 90.1%), small fibre neuropathy (n=91, 82.0%), pulmonary involvement (n=69, 62.2%), and/or...
Abstract BACKGROUND Interpretation of serial high-sensitivity cardiac troponin (hs-cTn) measurements for the diagnosis acute myocardial infarction (AMI) assumes random fluctuation hs-cTn around an individual's homeostatic set point. The aim this study was to challenge diagnostic concept. METHODS Study 1 examined presence a diurnal rhythm by hourly blood sampling, day and night, in 24 individuals without recent history AMI. 2 assessed morning vs evening accuracy hs-cTnT hs-cTnI prospective...
Background: Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological analytical limitations thereby increase diagnostic accuracy for acute myocardial infarction with a single blood draw. We aimed to evaluate the performance combinations high-sensitivity (hs) cTnI hs-cTnT early diagnosis infarction. Methods: The combining hs-cTnI (Architect, Abbott) (Elecsys, Roche) concentrations (sum, product, ratio, combination...
<h3>Objective</h3> The 99th percentile upper reference limit of high-sensitivity cardiac troponin (hs-cTn) from a healthy population is used for diagnosing acute myocardial infarction (AMI). Accepted current thresholds hs-cTnT (Roche) and hs-cTnI (Abbott) are 14 26 ng/L, respectively. Since were derived different cohorts it unclear whether they biologically equivalent. We directly assessed sex-specific age-specific limits in single cohort, to investigate divergent stem intrinsic assay...
We have found previously that in acute myocardial infarction (AMI), cardiac troponin T (cTnT) is degraded a time-dependent pattern. investigated whether cTnT forms differed patients with chronic increases, as seen renal dysfunction, from those the phase of infarction.We separated by gel filtration chromatography (GFC) end-stage disease (ESRD) patients: prehemodialysis (pre-HD) and post-HD (n = 10) 2 months follow-up 6). Purified standards, quality control materials clinical immunoassay...
Background Closed-loop insulin delivery systems, which integrate continuous glucose monitoring (CGM) and algorithms that continuously guide dosing, have been shown to improve glycaemic control. The ability predict future values can further optimize such devices. In this study, we used machine learning train models in predicting levels based on prior CGM accelerometry data. Methods We data from Maastricht Study, an observational population‐based cohort comprises individuals with normal...
Mass spectrometry imaging (MSI) can analyze the spatial distribution of hundreds different molecules directly from tissue sections usually placed on conductive glass slides to provide conductivity sample surface. Additional experiments are often required for molecular identification using consecutive membrane compatible with laser capture microdissection (LMD). In this work, we demonstrate first time use a single slide both matrix-assisted desorption ionization (MALDI)-MSI and direct...
Abstract Tacrolimus, an immunosuppressant used after organ transplantation, has a narrow therapeutic range and its pharmacokinetic variability complicates daily dose assessment. P‐glycoprotein (P‐gp), encoded by the adenosine triphosphate‐binding cassette B1 ( ABCB1 ) cytochrome CYP 3A4 3A5 enzymes appears to play role in tacrolimus metabolism. In present study, two different renal transplant recipient groups were examine influence of CYP3A polymorphisms on several parameters. total 63...
Abstract Background: A vast amount of scientific research is directed towards the beneficial effects antioxidants on health. For this reason, several assays have been developed to determine total antioxidant capacity blood. Methods: In study two procedures based use green-blue 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical (ABTS
Summary The intracellular pathogens Propionibacterium acnes and Mycobacterium tuberculosis have been leading suspects as the cause of sarcoidosis, a systemic disorder characterized by formation non-caseating granulomas. Toll-like receptor (TLR) 2 is important in innate immune response against both pathogens, therefore interest sarcoidosis research. In present study, three single nucleotide polymorphisms one dinucleotide repeat polymorphism TLR-2 gene were genotyped 419 patients, divided into...
Abstract Purpose: This multicenter, phase II study evaluates the efficacy and safety of erlotinib, an epidermal growth factor receptor (EGFR) inhibitor, plus sorafenib, a multityrosine kinase inhibitor against vascular endothelial receptors, in patients with previously untreated advanced non–small cell lung cancer (NSCLC). Experimental Design: Chemotherapy-naïve stage IIIB/IV NSCLC received erlotinib (150 mg once day) sorafenib (400 twice until disease progression or unacceptable toxicity....
The course of the disease in SARS-CoV-2 infection mechanically ventilated patients is unknown. To unravel clinical heterogeneity these patients, we designed prospective observational Maastricht Intensive Care COVID cohort (MaastrICCht). We incorporated serial measurements that harbour aetiological, diagnostic and predictive information. study aims to investigate natural critically ill with a infection.Mechanically admitted intensive care will be included. collect variables, vital parameters,...