A5013924375- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Potassium and Related Disorders
- Cardiac electrophysiology and arrhythmias
- Healthcare cost, quality, practices
- ECG Monitoring and Analysis
- Advanced MRI Techniques and Applications
- MicroRNA in disease regulation
- Protease and Inhibitor Mechanisms
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Acute Kidney Injury Research
- Venous Thromboembolism Diagnosis and Management
- Molecular Biology Techniques and Applications
- Gut microbiota and health
University Hospital of Basel
2014-2023
University of Basel
2017-2023
Cardiovascular Institute Hospital
2016
Kantonsschule Olten
2015
Hospital Del Mar
2015
Brigham and Women's Hospital
2015
Harvard University
2015
Hospital Clínic de Barcelona
2015
Municipal Institute for Medical Research
2015
<h3>Background:</h3> We aimed to prospectively validate a novel 1-hour algorithm using high-sensitivity cardiac troponin T measurement for early rule-out and rule-in of acute myocardial infarction (MI). <h3>Methods:</h3> In multicentre study, we enrolled 1320 patients presenting the emergency department with suspected MI. The algorithm, incorporating baseline values as well absolute changes within first hour, was validated against final diagnosis. diagnosis then adjudicated by 2 independent...
It is unknown whether more sensitive cardiac troponin (cTn) assays maintain their clinical utility in patients with renal dysfunction. Moreover, optimal cutoff levels this vulnerable patient population have not previously been defined.In multicenter study, we examined the of 7 cTn (3 and 4 high-sensitivity assays) presenting symptoms suggestive acute myocardial infarction. Among 2813 unselected patients, 447 (16%) had dysfunction (defined as Modification Diet Renal Disease-estimated...
Background: Four strategies for very early rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (hs-cTnI) have been identified. It remains unclear which strategy is most attractive clinical application. Methods: We prospectively enrolled unselected patients presenting to the emergency department with symptoms suggestive infarction. The final diagnosis was adjudicated by 2 independent cardiologists. Hs-cTnI levels were measured at presentation and after 1 hour in...
It is currently unknown whether the uniform (universal clinical practice for more than 2 decades) or sex-specific cutoff levels are preferable when using high-sensitivity cardiac troponin T (hs-cTnT) in diagnosis of acute myocardial infarction (AMI).To improve management suspected AMI women by exploring vs hs-cTnT.In an ongoing prospective, diagnostic, multicenter study conducted at 9 emergency departments, present evaluated patients enrolled from April 21, 2006, through June 5, 2013. The...
Abstract BACKGROUND This study aimed to prospectively advance a rule-out strategy for functionally significant coronary artery disease (CAD) by use of high-sensitivity cardiac troponin I (hs-cTnI) from bench bedside, application 3-step approach: validation in serum, correlation plasma, and on clinical platform. METHODS Patients without known CAD referred rest/stress myocardial perfusion single-photon emission tomography/computer tomography (MPI-SPECT/CT) were assigned 3 consecutive cohorts:...
Trimethylamine N-oxide (TMAO) has been associated with cardiovascular outcomes. However, the diagnostic value of TMAO and its precursors have not assessed for functionally relevant coronary artery disease (fCAD) prognostic potential in this setting needs to be evaluated.Among 1726 patients suspected fCAD serum TMAO, betaine, choline carnitine, were quantified using liquid chromatography tandem mass spectrometry. Diagnosis was performed by myocardial perfusion single photon emission...
<h3>Objective</h3> Copeptin, a quantitative marker of endogenous stress, seems to provide incremental value in addition cardiac troponin the early rule-out acute myocardial infarction (AMI). Prevalence, characteristics and outcome chest pain patients with causes other than AMI elevated copeptin are poorly understood. <h3>Methods</h3> A total 984 consecutive non-cardiac were selected from prospective multicentre study presenting emergency department. Levels determined blinded fashion...
Background: The optimal noninvasive method for surveillance in symptomatic patients with stable coronary artery disease (CAD) is unknown. Objective: To apply a novel approach using very low concentrations of high-sensitivity cardiac troponin I (hs-cTnI) exclusion inducible myocardial ischemia CAD. Design: Prospective diagnostic cohort study. (ClinicalTrials.gov: NCT01838148) Setting: University hospital. Patients: 1896 consecutive CAD referred symptoms possibly related to ischemia....
We aimed to directly compare high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) in the detection of functionally relevant coronary artery disease (fCAD).Consecutive patients referred with clinical suspicion fCAD no structural heart other than were included. The presence was based on rest/stress myocardial perfusion single-photon emission computed tomography/computed tomography angiography. hs-cTnI hs-cTnT concentrations measured a blinded fashion. Diagnostic accuracy quantified...
Despite clinical suspicion, many non-invasive tests for coronary artery disease (CAD) are normal. Coronary calcification score (CACS) is a well-validated method to detect and risk stratify CAD. Patients with zero calcium (ZCS) rarely have abnormal tests. Therefore, aims were evaluate CACS as gatekeeper further functional downstream testing CAD estimate potential radiation cost savings.
Little is known about the gatekeeper performance of coronary artery calcium score (CACS) before myocardial perfusion positron emission tomography (PET), compared with updated pre-test probabilities from American and European guidelines (pre-test-AHA/ACC, pre-test-ESC).